B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid)
CBA/N mice carry an X-linked recessive immunodeficiency (xid) gene manifested by the absence of a B lymphocyte subpopulation, but the manner in which the xid gene exerts its effect on B lymphocyte development is unknown. The production of B lymphocytes in the bone marrow of CBA/N mice has now been c...
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Veröffentlicht in: | The Journal of immunology (1950) 1985-10, Vol.135 (4), p.2299-2302 |
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description | CBA/N mice carry an X-linked recessive immunodeficiency (xid) gene manifested by the absence of a B lymphocyte subpopulation, but the manner in which the xid gene exerts its effect on B lymphocyte development is unknown. The production of B lymphocytes in the bone marrow of CBA/N mice has now been compared with that of normal CBA/J mice by using two in vivo assays: immunofluorescence stathmokinetic studies measured pre-B cell proliferation, whereas radioautographic [3H]thymidine labeling was used to evaluate small lymphocyte turnover. Although the total cellularity of CBA/N mouse bone marrow was greater than normal, the absolute number of marrow small lymphocytes, pre-B cells, and B lymphocytes were all similar to those in CBA/J controls. Furthermore, in the bone marrow of CBA/N mice, the proliferation rate of pre-B cells, calculated from their rate of entry into mitosis, and the turnover rate of small lymphocytes, derived from their rate of [3H]thymidine labeling, were not significantly different from those seen in nondefective mice. The present findings that pre-B cell proliferation and small lymphocyte production proceed at similar rates in the bone marrow of xid and normal mice suggest that the xid gene does not act at the level of primary B cell genesis in the bone marrow. The findings are in accord with the view that the xid gene produces a maturation block or a functional abnormality among B lymphocytes in the peripheral lymphoid tissues rather than the deletion of a sublineage of B lymphocytes in the bone marrow. |
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The production of B lymphocytes in the bone marrow of CBA/N mice has now been compared with that of normal CBA/J mice by using two in vivo assays: immunofluorescence stathmokinetic studies measured pre-B cell proliferation, whereas radioautographic [3H]thymidine labeling was used to evaluate small lymphocyte turnover. Although the total cellularity of CBA/N mouse bone marrow was greater than normal, the absolute number of marrow small lymphocytes, pre-B cells, and B lymphocytes were all similar to those in CBA/J controls. Furthermore, in the bone marrow of CBA/N mice, the proliferation rate of pre-B cells, calculated from their rate of entry into mitosis, and the turnover rate of small lymphocytes, derived from their rate of [3H]thymidine labeling, were not significantly different from those seen in nondefective mice. The present findings that pre-B cell proliferation and small lymphocyte production proceed at similar rates in the bone marrow of xid and normal mice suggest that the xid gene does not act at the level of primary B cell genesis in the bone marrow. The findings are in accord with the view that the xid gene produces a maturation block or a functional abnormality among B lymphocytes in the peripheral lymphoid tissues rather than the deletion of a sublineage of B lymphocytes in the bone marrow.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.135.4.2299</identifier><identifier>PMID: 3875649</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Animals ; Applied sciences ; B-Lymphocytes - classification ; B-Lymphocytes - immunology ; B-Lymphocytes - pathology ; Biological and medical sciences ; Bone Marrow - pathology ; Cell Cycle ; Crosses, Genetic ; Exact sciences and technology ; Female ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunologic Deficiency Syndromes - genetics ; Immunologic Deficiency Syndromes - immunology ; Immunologic Deficiency Syndromes - pathology ; Immunopathology ; Lymphocyte Activation ; Lymphocytes - classification ; Male ; Medical sciences ; Mice ; Mice, Inbred CBA ; Mice, Mutant Strains - immunology ; Other techniques and industries ; Sex Characteristics ; Stem Cells - classification ; Stem Cells - pathology ; X Chromosome</subject><ispartof>The Journal of immunology (1950), 1985-10, Vol.135 (4), p.2299-2302</ispartof><rights>1987 INIST-CNRS</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3509-484a02e8c00526390820b0bc1779a88f8595fe0493a4e48f6a506a4f9b3bc6603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7975407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8816835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3875649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reid, GK</creatorcontrib><creatorcontrib>Osmond, DG</creatorcontrib><title>B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid)</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>CBA/N mice carry an X-linked recessive immunodeficiency (xid) gene manifested by the absence of a B lymphocyte subpopulation, but the manner in which the xid gene exerts its effect on B lymphocyte development is unknown. The production of B lymphocytes in the bone marrow of CBA/N mice has now been compared with that of normal CBA/J mice by using two in vivo assays: immunofluorescence stathmokinetic studies measured pre-B cell proliferation, whereas radioautographic [3H]thymidine labeling was used to evaluate small lymphocyte turnover. Although the total cellularity of CBA/N mouse bone marrow was greater than normal, the absolute number of marrow small lymphocytes, pre-B cells, and B lymphocytes were all similar to those in CBA/J controls. Furthermore, in the bone marrow of CBA/N mice, the proliferation rate of pre-B cells, calculated from their rate of entry into mitosis, and the turnover rate of small lymphocytes, derived from their rate of [3H]thymidine labeling, were not significantly different from those seen in nondefective mice. The present findings that pre-B cell proliferation and small lymphocyte production proceed at similar rates in the bone marrow of xid and normal mice suggest that the xid gene does not act at the level of primary B cell genesis in the bone marrow. The findings are in accord with the view that the xid gene produces a maturation block or a functional abnormality among B lymphocytes in the peripheral lymphoid tissues rather than the deletion of a sublineage of B lymphocytes in the bone marrow.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>B-Lymphocytes - classification</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Cell Cycle</subject><subject>Crosses, Genetic</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunologic Deficiency Syndromes - genetics</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Immunologic Deficiency Syndromes - pathology</subject><subject>Immunopathology</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - classification</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Mutant Strains - immunology</subject><subject>Other techniques and industries</subject><subject>Sex Characteristics</subject><subject>Stem Cells - classification</subject><subject>Stem Cells - pathology</subject><subject>X Chromosome</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1DAUhS0EKtPCEyAkLxCFRYbrf3sJFdBKldiAYGc5jk1c8jONE4V5e1zNUHXXlRf3u9fnfAi9IrDlwM2Hm9T3yzB2W8LElm8pNeYJ2hAhoJIS5FO0AaC0Ikqq5-g05xsAkED5CTphWgnJzQb9_IS7fb9rR7-fA95NY7P4OY0DTgOe24DrcQi4d9M0rniMuE8-4DXNLf5VdWn4Exp8CNGEmHwKg9_jd39T8_4FehZdl8PL43uGfnz5_P3isrr-9vXq4uN15ZkAU3HNHdCgPYCgkhnQFGqoPVHKOK2jFkbEUMoyxwPXUToB0vFoalb7UpKdobeHuyX67RLybPuUfeg6N4RxyVZJqoEQWkB2AP005jyFaHdTKsX2loC902n_67RFp-X2TmfZen08v9R9aO53jv7K_M1x7rJ3XZzc4FO-x7QmUjPxGKaMEhxUwc4PWJt-t2uags2967ryN7Hruj7I9Q_b6Zjt</recordid><startdate>198510</startdate><enddate>198510</enddate><creator>Reid, GK</creator><creator>Osmond, DG</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198510</creationdate><title>B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid)</title><author>Reid, GK ; Osmond, DG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3509-484a02e8c00526390820b0bc1779a88f8595fe0493a4e48f6a506a4f9b3bc6603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>B-Lymphocytes - classification</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Cell Cycle</topic><topic>Crosses, Genetic</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunologic Deficiency Syndromes - genetics</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Immunologic Deficiency Syndromes - pathology</topic><topic>Immunopathology</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - classification</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Mutant Strains - immunology</topic><topic>Other techniques and industries</topic><topic>Sex Characteristics</topic><topic>Stem Cells - classification</topic><topic>Stem Cells - pathology</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reid, GK</creatorcontrib><creatorcontrib>Osmond, DG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reid, GK</au><au>Osmond, DG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid)</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1985-10</date><risdate>1985</risdate><volume>135</volume><issue>4</issue><spage>2299</spage><epage>2302</epage><pages>2299-2302</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>CBA/N mice carry an X-linked recessive immunodeficiency (xid) gene manifested by the absence of a B lymphocyte subpopulation, but the manner in which the xid gene exerts its effect on B lymphocyte development is unknown. The production of B lymphocytes in the bone marrow of CBA/N mice has now been compared with that of normal CBA/J mice by using two in vivo assays: immunofluorescence stathmokinetic studies measured pre-B cell proliferation, whereas radioautographic [3H]thymidine labeling was used to evaluate small lymphocyte turnover. Although the total cellularity of CBA/N mouse bone marrow was greater than normal, the absolute number of marrow small lymphocytes, pre-B cells, and B lymphocytes were all similar to those in CBA/J controls. Furthermore, in the bone marrow of CBA/N mice, the proliferation rate of pre-B cells, calculated from their rate of entry into mitosis, and the turnover rate of small lymphocytes, derived from their rate of [3H]thymidine labeling, were not significantly different from those seen in nondefective mice. The present findings that pre-B cell proliferation and small lymphocyte production proceed at similar rates in the bone marrow of xid and normal mice suggest that the xid gene does not act at the level of primary B cell genesis in the bone marrow. The findings are in accord with the view that the xid gene produces a maturation block or a functional abnormality among B lymphocytes in the peripheral lymphoid tissues rather than the deletion of a sublineage of B lymphocytes in the bone marrow.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>3875649</pmid><doi>10.4049/jimmunol.135.4.2299</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Applied sciences B-Lymphocytes - classification B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences Bone Marrow - pathology Cell Cycle Crosses, Genetic Exact sciences and technology Female Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - pathology Immunopathology Lymphocyte Activation Lymphocytes - classification Male Medical sciences Mice Mice, Inbred CBA Mice, Mutant Strains - immunology Other techniques and industries Sex Characteristics Stem Cells - classification Stem Cells - pathology X Chromosome |
title | B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid) |
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