Pattern formation in the limbs of Drosophila: bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus
We have identified the gene bric a brac and show that it is required for pattern formation along the proximal-distal axis of the leg and antenna of Drosophila. In bric a brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal...
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| Veröffentlicht in: | Development (Cambridge) 1993-11, Vol.119 (3), p.799-812 |
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| container_title | Development (Cambridge) |
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| creator | Godt, D Couderc, J L Cramton, S E Laski, F A |
| description | We have identified the gene bric a brac and show that it is required for pattern formation along the proximal-distal axis of the leg and antenna of Drosophila. In bric a brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal tarsal segment. In addition, bric a brac mutant legs and antennae have segmentation defects. bric a brac encodes a nuclear protein that shares a highly conserved domain with two transcription factors from Drosophila. bric a brac function is dosage dependent and is required in a graded manner for the specification of tarsal segments. The graded requirement for bric a brac correlates with its graded expression pattern, suggesting that the concentration of BRIC A BRAC protein specifies segment identity in the tarsus. |
| doi_str_mv | 10.1242/dev.119.3.799 |
| format | Article |
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In bric a brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal tarsal segment. In addition, bric a brac mutant legs and antennae have segmentation defects. bric a brac encodes a nuclear protein that shares a highly conserved domain with two transcription factors from Drosophila. bric a brac function is dosage dependent and is required in a graded manner for the specification of tarsal segments. 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| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1993-11, Vol.119 (3), p.799-812 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76272548 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Extremities - embryology Gene Expression - physiology Genes, Homeobox - physiology In Situ Hybridization Morphogenesis - genetics Mutation - genetics Phenotype |
| title | Pattern formation in the limbs of Drosophila: bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus |
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