Development of resistance in Pseudomonas aeruginosa to broad-spectrum cephalosporins via step-wise mutations
Step-wise resistance to cefepime, ceftazidime, cefotaxime, and cefpirome were determined for 16 Pseudomonas aeruginosa strains by daily transfer for 7 days to fresh media containing two-fold serial dilution of antibiotic. By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1993-11, Vol.32 (suppl-B), p.75-80 |
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| container_end_page | 80 |
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| container_issue | suppl-B |
| container_start_page | 75 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 32 |
| creator | Gradelski, Elizabeth Fung-Tomc, Joan Huczko, Elizabeth Kessler, Robert E. |
| description | Step-wise resistance to cefepime, ceftazidime, cefotaxime, and cefpirome were determined for 16 Pseudomonas aeruginosa strains by daily transfer for 7 days to fresh media containing two-fold serial dilution of antibiotic. By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to ceftazidime compared with none, five (31%) and ten (60%) strains becoming resistant to cefepime, cefpirome and cefotaxime (MIC ≥ 64 mg/L), respectively. At the end of the 7 day serial transfer, only four (25%) of the 16 strains were resistant to cefepime, in contrast to nine (56%) cefpirome resistant, 12 (75%) ceftazidime resistant and 13 (81%) cefotaxime resistant. These results are consistent with the infrequent, single-step development of resistance to cefepime, and this may also explain the frequent cefepime susceptibility of cefotaxime/ceftazidime-resistant clinical isolates of P. aeruginosa. |
| doi_str_mv | 10.1093/jac/32.suppl_B.75 |
| format | Article |
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By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to ceftazidime compared with none, five (31%) and ten (60%) strains becoming resistant to cefepime, cefpirome and cefotaxime (MIC ≥ 64 mg/L), respectively. At the end of the 7 day serial transfer, only four (25%) of the 16 strains were resistant to cefepime, in contrast to nine (56%) cefpirome resistant, 12 (75%) ceftazidime resistant and 13 (81%) cefotaxime resistant. These results are consistent with the infrequent, single-step development of resistance to cefepime, and this may also explain the frequent cefepime susceptibility of cefotaxime/ceftazidime-resistant clinical isolates of P. aeruginosa.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/32.suppl_B.75</identifier><identifier>PMID: 8150769</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cephalosporins - pharmacology ; Drug Resistance, Microbial - genetics ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Mutation ; Pharmacology. 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By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to ceftazidime compared with none, five (31%) and ten (60%) strains becoming resistant to cefepime, cefpirome and cefotaxime (MIC ≥ 64 mg/L), respectively. At the end of the 7 day serial transfer, only four (25%) of the 16 strains were resistant to cefepime, in contrast to nine (56%) cefpirome resistant, 12 (75%) ceftazidime resistant and 13 (81%) cefotaxime resistant. These results are consistent with the infrequent, single-step development of resistance to cefepime, and this may also explain the frequent cefepime susceptibility of cefotaxime/ceftazidime-resistant clinical isolates of P. aeruginosa.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cephalosporins - pharmacology</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Mutation</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cephalosporins - pharmacology</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Mutation</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas aeruginosa - genetics</topic><topic>Pseudomonas Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gradelski, Elizabeth</creatorcontrib><creatorcontrib>Fung-Tomc, Joan</creatorcontrib><creatorcontrib>Huczko, Elizabeth</creatorcontrib><creatorcontrib>Kessler, Robert E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gradelski, Elizabeth</au><au>Fung-Tomc, Joan</au><au>Huczko, Elizabeth</au><au>Kessler, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of resistance in Pseudomonas aeruginosa to broad-spectrum cephalosporins via step-wise mutations</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>32</volume><issue>suppl-B</issue><spage>75</spage><epage>80</epage><pages>75-80</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Step-wise resistance to cefepime, ceftazidime, cefotaxime, and cefpirome were determined for 16 Pseudomonas aeruginosa strains by daily transfer for 7 days to fresh media containing two-fold serial dilution of antibiotic. 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| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1993-11, Vol.32 (suppl-B), p.75-80 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cephalosporins - pharmacology Drug Resistance, Microbial - genetics Humans Medical sciences Microbial Sensitivity Tests Mutation Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas Infections - microbiology |
| title | Development of resistance in Pseudomonas aeruginosa to broad-spectrum cephalosporins via step-wise mutations |
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