Pharmacokinetics of chlorpromazine and key metabolites

A study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (i.v.) dose (10 mg) and three single oral doses (25, 50 and 100 mg), with a washout period of two weeks between doses. Plasma levels of CPZ, CPZ N-oxide (CPZNO), CPZ...

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Veröffentlicht in:	European journal of clinical pharmacology 1993-12, Vol.45 (6), p.563-569
Hauptverfasser:	YEUNG, P. K.-F, HUBBARD, J. W, KORCHINSKI, E. D, MIDHA, K. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Biological and medical sciences Biotransformation Chlorpromazine - administration & dosage Chlorpromazine - chemistry Chlorpromazine - pharmacokinetics Half-Life Humans Injections, Intravenous Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Radioimmunoassay
Online-Zugang:	Volltext
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