Intravenous administration of the serotonin agonist m-chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats

The serotonin (5-HT) agonist 1-(- m-chlorophenyl)piperazine (mCPP) has been widely used as a pharmacological probe to assess 5-HT function. Although mCPP is known to interact with 5-HT receptors, this drug is also reported to exhibit presynaptic actions that increase extraneuronal 5-HT in vitro. In...

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Veröffentlicht in:	Neuropharmacology 1993-12, Vol.32 (12), p.1381-1386
Hauptverfasser:	Baumann, M.H., Ruiter, J.J., Auerbach, S.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Diencephalon - drug effects Diencephalon - metabolism fluoxetine Fluoxetine - pharmacology Fundamental and applied biological sciences. Psychology Injections, Intravenous Kinetics Male mCPP Microdialysis Piperazines - administration & dosage Piperazines - pharmacology presynaptic prolactin Prolactin - blood Rats Rats, Sprague-Dawley serotonin Serotonin - metabolism Serotonin Receptor Agonists - pharmacology Time Factors Vertebrates: nervous system and sense organs
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