The changes in the permeability of the blood-brain barrier when under neurosurgical intervention
The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were f...
Gespeichert in:
| Veröffentlicht in: | Molecular and chemical neuropathology 1993-12, Vol.20 (3), p.197-202 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 202 |
|---|---|
| container_issue | 3 |
| container_start_page | 197 |
| container_title | Molecular and chemical neuropathology |
| container_volume | 20 |
| creator | Khokhlov, A P Fetisova, I G Chekhonin, V P Malakhovsky, V K |
| description | The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24-48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d. According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed. |
| doi_str_mv | 10.1007/BF03160073 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76268689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76268689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-a276c37453486193485ebcc28f50187a67016e47417a263a12f38b4a34ee1d183</originalsourceid><addsrcrecordid>eNpFkL1PwzAQxT2ASiks7EiZGJAC_qrtjlBRQKrEUuZgO5fWKLGLnYD632NoBcvdu7ufnk4PoQuCbwjG8vZ-gRkRWbEjNCaY81KyGTtBpym9YywoU3SERopIKigfo7fVBgq70X4NqXC-6PO4hdiBNq51_a4Ize_OtCHUpYk6M0bH6CAWXxvwxeDrLD0MMaQhrp3VbfbpIX6C713wZ-i40W2C80OfoNfFw2r-VC5fHp_nd8vSUkX7UlMpLJN8yrgSZJbrFIzNt2aKiZJaSEwEcMmJ1FQwTWjDlOGacQBSE8Um6Grvu43hY4DUV51LFtpWewhDqqSgQgk1y-D1HrT54xShqbbRdTruKoKrnwir_wgzfHlwHUwH9R96yI99AzfpbR0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76268689</pqid></control><display><type>article</type><title>The changes in the permeability of the blood-brain barrier when under neurosurgical intervention</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Khokhlov, A P ; Fetisova, I G ; Chekhonin, V P ; Malakhovsky, V K</creator><creatorcontrib>Khokhlov, A P ; Fetisova, I G ; Chekhonin, V P ; Malakhovsky, V K</creatorcontrib><description>The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24-48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d. According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed.</description><identifier>ISSN: 1044-7393</identifier><identifier>DOI: 10.1007/BF03160073</identifier><identifier>PMID: 8172624</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Anesthesia ; Antibody Formation - physiology ; Antigen-Antibody Reactions - physiology ; Biomarkers ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiology ; Brain - surgery ; Brain Injuries - surgery ; Brain Neoplasms - surgery ; Humans ; Middle Aged ; Nerve Tissue Proteins - blood ; Nerve Tissue Proteins - metabolism ; Neuroglia - metabolism ; Postoperative Period</subject><ispartof>Molecular and chemical neuropathology, 1993-12, Vol.20 (3), p.197-202</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-a276c37453486193485ebcc28f50187a67016e47417a263a12f38b4a34ee1d183</citedby><cites>FETCH-LOGICAL-c282t-a276c37453486193485ebcc28f50187a67016e47417a263a12f38b4a34ee1d183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8172624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khokhlov, A P</creatorcontrib><creatorcontrib>Fetisova, I G</creatorcontrib><creatorcontrib>Chekhonin, V P</creatorcontrib><creatorcontrib>Malakhovsky, V K</creatorcontrib><title>The changes in the permeability of the blood-brain barrier when under neurosurgical intervention</title><title>Molecular and chemical neuropathology</title><addtitle>Mol Chem Neuropathol</addtitle><description>The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24-48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d. According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Antibody Formation - physiology</subject><subject>Antigen-Antibody Reactions - physiology</subject><subject>Biomarkers</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - surgery</subject><subject>Brain Injuries - surgery</subject><subject>Brain Neoplasms - surgery</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neuroglia - metabolism</subject><subject>Postoperative Period</subject><issn>1044-7393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAQxT2ASiks7EiZGJAC_qrtjlBRQKrEUuZgO5fWKLGLnYD632NoBcvdu7ufnk4PoQuCbwjG8vZ-gRkRWbEjNCaY81KyGTtBpym9YywoU3SERopIKigfo7fVBgq70X4NqXC-6PO4hdiBNq51_a4Ize_OtCHUpYk6M0bH6CAWXxvwxeDrLD0MMaQhrp3VbfbpIX6C713wZ-i40W2C80OfoNfFw2r-VC5fHp_nd8vSUkX7UlMpLJN8yrgSZJbrFIzNt2aKiZJaSEwEcMmJ1FQwTWjDlOGacQBSE8Um6Grvu43hY4DUV51LFtpWewhDqqSgQgk1y-D1HrT54xShqbbRdTruKoKrnwir_wgzfHlwHUwH9R96yI99AzfpbR0</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Khokhlov, A P</creator><creator>Fetisova, I G</creator><creator>Chekhonin, V P</creator><creator>Malakhovsky, V K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199312</creationdate><title>The changes in the permeability of the blood-brain barrier when under neurosurgical intervention</title><author>Khokhlov, A P ; Fetisova, I G ; Chekhonin, V P ; Malakhovsky, V K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-a276c37453486193485ebcc28f50187a67016e47417a263a12f38b4a34ee1d183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Antibody Formation - physiology</topic><topic>Antigen-Antibody Reactions - physiology</topic><topic>Biomarkers</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - surgery</topic><topic>Brain Injuries - surgery</topic><topic>Brain Neoplasms - surgery</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neuroglia - metabolism</topic><topic>Postoperative Period</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khokhlov, A P</creatorcontrib><creatorcontrib>Fetisova, I G</creatorcontrib><creatorcontrib>Chekhonin, V P</creatorcontrib><creatorcontrib>Malakhovsky, V K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and chemical neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khokhlov, A P</au><au>Fetisova, I G</au><au>Chekhonin, V P</au><au>Malakhovsky, V K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The changes in the permeability of the blood-brain barrier when under neurosurgical intervention</atitle><jtitle>Molecular and chemical neuropathology</jtitle><addtitle>Mol Chem Neuropathol</addtitle><date>1993-12</date><risdate>1993</risdate><volume>20</volume><issue>3</issue><spage>197</spage><epage>202</epage><pages>197-202</pages><issn>1044-7393</issn><abstract>The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery: 1. Neurosurgical brain trauma did not change the permeability of BBB. 2. Anesthesia resulted in increasing permeability of BBB with peak upon 24-48 h. 3. High blood levels of neurospecific proteins proved protein synthesis in glial cells. 4. Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d. According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed.</abstract><cop>United States</cop><pmid>8172624</pmid><doi>10.1007/BF03160073</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1044-7393 |
| ispartof | Molecular and chemical neuropathology, 1993-12, Vol.20 (3), p.197-202 |
| issn | 1044-7393 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76268689 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Anesthesia Antibody Formation - physiology Antigen-Antibody Reactions - physiology Biomarkers Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain - surgery Brain Injuries - surgery Brain Neoplasms - surgery Humans Middle Aged Nerve Tissue Proteins - blood Nerve Tissue Proteins - metabolism Neuroglia - metabolism Postoperative Period |
| title | The changes in the permeability of the blood-brain barrier when under neurosurgical intervention |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T06%3A11%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20changes%20in%20the%20permeability%20of%20the%20blood-brain%20barrier%20when%20under%20neurosurgical%20intervention&rft.jtitle=Molecular%20and%20chemical%20neuropathology&rft.au=Khokhlov,%20A%20P&rft.date=1993-12&rft.volume=20&rft.issue=3&rft.spage=197&rft.epage=202&rft.pages=197-202&rft.issn=1044-7393&rft_id=info:doi/10.1007/BF03160073&rft_dat=%3Cproquest_cross%3E76268689%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76268689&rft_id=info:pmid/8172624&rfr_iscdi=true |