Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells

Background LOX-1, a lectin-like receptor on endothelial cells, facilitates the uptake of oxidized low-density lipoprotein (oxLDL). Expression of LOX-1 is involved in the pathobiological effects of oxLDL in endothelial cells, including reactive oxygen species (ROS) generation, suppression of endothel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of vascular surgery 2010-11, Vol.52 (5), p.1290-1300
Hauptverfasser:	Lee, Wen-Jane, PhD, Ou, Hsiu-Chung, PhD, Hsu, Wen-Cheng, MD, Chou, Min-Min, MD, Tseng, Jenn-Jhy, MD, PhD, Hsu, Shih-Lan, PhD, Tsai, Kun-Ling, MS, Sheu, Wayne Huey-Herng, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Biological and medical sciences Cardiovascular system Cell Adhesion Molecules - metabolism Cells, Cultured Dose-Response Relationship, Drug Down-Regulation Ellagic Acid - pharmacology Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - metabolism Enzyme Inhibitors - pharmacology Humans Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Inflammation Mediators - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Investigative techniques, diagnostic techniques (general aspects) Lipoproteins, LDL - metabolism Medical sciences NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism NF-kappa B - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Onium Compounds - pharmacology p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Radionuclide investigations Reactive Oxygen Species - metabolism Scavenger Receptors, Class E - metabolism Signal Transduction - drug effects Superoxides - metabolism Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!