Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia
These experiments were undertaken to determine whether arginine vasopressin (AVP) could suppress a prostaglandin hyperthermia and to localize sites of these actions in the rat. Prostaglandin E 2 (PGE 2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 μl of pros...
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| Veröffentlicht in: | Brain research 1985-07, Vol.338 (2), p.219-224 |
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| container_title | Brain research |
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| creator | Ruwe, W.D. Naylor, A.M. Veale, W.L. |
| description | These experiments were undertaken to determine whether arginine vasopressin (AVP) could suppress a prostaglandin hyperthermia and to localize sites of these actions in the rat. Prostaglandin E
2 (PGE
2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 μl of prostaglandin E
2. During perfusion with an artificial CSF, PGE
2 injected into the lateral cerebral ventricle evoked a hyperthermia of more than 1 °C. Perfusion of 6.5 μg/ml of AVP markedly attenuated the PGE
2-induced hyperthermia. These results suggest that AVP suppresses PGE
2-induced hyperthermia in sites in which PGE
2 evokes an increase in core temperature. |
| doi_str_mv | 10.1016/0006-8993(85)90150-7 |
| format | Article |
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2 (PGE
2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 μl of prostaglandin E
2. During perfusion with an artificial CSF, PGE
2 injected into the lateral cerebral ventricle evoked a hyperthermia of more than 1 °C. Perfusion of 6.5 μg/ml of AVP markedly attenuated the PGE
2-induced hyperthermia. These results suggest that AVP suppresses PGE
2-induced hyperthermia in sites in which PGE
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2 (PGE
2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 μl of prostaglandin E
2. During perfusion with an artificial CSF, PGE
2 injected into the lateral cerebral ventricle evoked a hyperthermia of more than 1 °C. Perfusion of 6.5 μg/ml of AVP markedly attenuated the PGE
2-induced hyperthermia. These results suggest that AVP suppresses PGE
2-induced hyperthermia in sites in which PGE
2 evokes an increase in core temperature.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Arginine Vasopressin - physiology</subject><subject>Dinoprostone</subject><subject>endogenous antipyresis</subject><subject>Exact sciences and technology</subject><subject>fever</subject><subject>Fever - physiopathology</subject><subject>Hyperthermia, Induced</subject><subject>Male</subject><subject>Other techniques and industries</subject><subject>PGE 2</subject><subject>Prostaglandins - physiology</subject><subject>Prostaglandins E - antagonists & inhibitors</subject><subject>push-pull perfusion</subject><subject>Rats</subject><subject>Septum Pellucidum - drug effects</subject><subject>vasopressin</subject><subject>ventral septal area</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFL5DAUx8Oi6Kj7DVboQUQPXZM2TdKLIDK6grAe9Bxek9edyExb81oXv70ZZ5ijp_D4_97Lnx9jvwT_LbhQV5xzlZu6Li9MdVlzUfFc_2AzYXSRq0LyPTbbIYfsiOg1jWVZ8wN2UBolCq5n7OUJYztR6Lusb7N3oH6ISBS67H8YF-kZF5hFGLMmQppoGr5ypGyIPY3wbwmdT8E8X3wMGBMdVwFO2H4LS8Kf2_eYvdzNn2__5I9_7x9ubx5zlwqMeeHqUqORwhttGgeNBCEMNLyFmnvZKKF8pSrTNFqWqAsttHfgjdegaunr8pidb-6mMm8T0mhXgRwuUynsJ7JaFcqUUiVQbkCXWlPE1g4xrCB-WMHt2qZdq7JrVdZU9sum1WntdHt_albod0tbfSk_2-ZADpZthM4F2mHGSM6r9e_XGwyTi_eA0ZIL2Dn0IaIbre_D9z0-AVDGkdk</recordid><startdate>19850715</startdate><enddate>19850715</enddate><creator>Ruwe, W.D.</creator><creator>Naylor, A.M.</creator><creator>Veale, W.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850715</creationdate><title>Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia</title><author>Ruwe, W.D. ; Naylor, A.M. ; Veale, W.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2c937e841d878bcab4a118ab0fa90d4b616d5658bb743e72717dcad8d7a694d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>Arginine Vasopressin - physiology</topic><topic>Dinoprostone</topic><topic>endogenous antipyresis</topic><topic>Exact sciences and technology</topic><topic>fever</topic><topic>Fever - physiopathology</topic><topic>Hyperthermia, Induced</topic><topic>Male</topic><topic>Other techniques and industries</topic><topic>PGE 2</topic><topic>Prostaglandins - physiology</topic><topic>Prostaglandins E - antagonists & inhibitors</topic><topic>push-pull perfusion</topic><topic>Rats</topic><topic>Septum Pellucidum - drug effects</topic><topic>vasopressin</topic><topic>ventral septal area</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruwe, W.D.</creatorcontrib><creatorcontrib>Naylor, A.M.</creatorcontrib><creatorcontrib>Veale, W.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruwe, W.D.</au><au>Naylor, A.M.</au><au>Veale, W.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1985-07-15</date><risdate>1985</risdate><volume>338</volume><issue>2</issue><spage>219</spage><epage>224</epage><pages>219-224</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>These experiments were undertaken to determine whether arginine vasopressin (AVP) could suppress a prostaglandin hyperthermia and to localize sites of these actions in the rat. Prostaglandin E
2 (PGE
2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 μl of prostaglandin E
2. During perfusion with an artificial CSF, PGE
2 injected into the lateral cerebral ventricle evoked a hyperthermia of more than 1 °C. Perfusion of 6.5 μg/ml of AVP markedly attenuated the PGE
2-induced hyperthermia. These results suggest that AVP suppresses PGE
2-induced hyperthermia in sites in which PGE
2 evokes an increase in core temperature.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3861207</pmid><doi>10.1016/0006-8993(85)90150-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1985-07, Vol.338 (2), p.219-224 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76268346 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Applied sciences Arginine Vasopressin - pharmacology Arginine Vasopressin - physiology Dinoprostone endogenous antipyresis Exact sciences and technology fever Fever - physiopathology Hyperthermia, Induced Male Other techniques and industries PGE 2 Prostaglandins - physiology Prostaglandins E - antagonists & inhibitors push-pull perfusion Rats Septum Pellucidum - drug effects vasopressin ventral septal area |
| title | Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia |
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