Early events in the experimental interstitial lung disease induced in sheep by the Visna-maedi virus

Visna-maedi virus is a lentivirus closely related to the human immunodeficiency virus type I (HIV-I). During spontaneous infection of sheep by Visna-maedi virus an interstitial lung disease is observed. It is characterized by an alveolitis, peribronchovascular lymphoid nodules, alveolar wall thicken...

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Veröffentlicht in:	Immunology letters 1993-12, Vol.39 (1), p.39-43
Hauptverfasser:	Cadoré, J.L., Guiguen, F., Cordier, G., Loire, R., Lyon, M., Chastang, J., Greenland, T., Court-Fortune, I., Revel, D., Mornex, J.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animal viral diseases Animals Animals, Newborn Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cells, Cultured Female Fibroblasts - microbiology Infectious diseases Interstitial lung disease Lentivirus Leukocyte Count Male Medical sciences Pneumonia, Progressive Interstitial, of Sheep - diagnostic imaging Pneumonia, Progressive Interstitial, of Sheep - immunology Pneumonia, Progressive Interstitial, of Sheep - pathology Radiography Sheep Viral diseases Visna-maedi Visna-maedi virus - growth & development Visna-maedi virus - immunology
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Beschreibung
Zusammenfassung:	Visna-maedi virus is a lentivirus closely related to the human immunodeficiency virus type I (HIV-I). During spontaneous infection of sheep by Visna-maedi virus an interstitial lung disease is observed. It is characterized by an alveolitis, peribronchovascular lymphoid nodules, alveolar wall thickening and myomatosis. In order to decipher the pathology of this lentiviral infection we have induced this disease in colostrum-deprived newborn lambs.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/0165-2478(93)90162-U