Glucocorticoids are modulators of GABAA receptors in brain

Modulation of binding of [3H]muscimol, a GABAA receptor agonist, by natural and synthetic glucocorticoids was investigated in crude synaptosomal membranes and in brain sections of rat. In adrenalectomized (Adx) rats, muscimol binding was reduced by 30-50% in cerebral cortex, cerebellum, thalamus and...

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Veröffentlicht in:	Brain research 1985-07, Vol.339 (1), p.178-182
Hauptverfasser:	MAJEWSKA, M. D, BISSERBE, J.-C, ESKAY, R. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Applied sciences Brain - physiology Corticosterone - pharmacology Dexamethasone - pharmacology Exact sciences and technology Glucocorticoids - physiology Muscimol - metabolism Other techniques and industries Pregnenolone - pharmacology Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Receptors, GABA-A - physiology
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