Changes in the Pulmonary Glucocorticoid Receptor Content in the Course of Interstitial Disease
The level of cytosolic glucocorticoid receptors (GR) was measured in 12 open-chest lung biopsies of interstitial pulmonary diseases. The results showed an increase in the GR content in the diseased lungs correlated to the degree of septal cellularity in nine cases. Two pulmonary sarcoidosis and one...
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| Veröffentlicht in: | Chest 1985-09, Vol.88 (3), p.417-419 |
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| container_title | Chest |
| container_volume | 88 |
| creator | Saidiva, Paulo Hilàrio Nascimento Mitzi Brentani, Maria de Carvalho, Carlos R.R. Otávio, José Auler, C. Fernandes Calheiros, Débora Pacheco, Mércia M. |
| description | The level of cytosolic glucocorticoid receptors (GR) was measured in 12 open-chest lung biopsies of interstitial pulmonary diseases. The results showed an increase in the GR content in the diseased lungs correlated to the degree of septal cellularity in nine cases. Two pulmonary sarcoidosis and one end-stage idiopathic pulmonary fibrosis patients presented higher levels of GR than those predicted by the septal cellularity. It was concluded that the GR content of the lungs increases in the course of interstitial diseases, reflecting the number of cells that express cytosolic GR in pulmonary parenchyma. |
| doi_str_mv | 10.1378/chest.88.3.417 |
| format | Article |
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The results showed an increase in the GR content in the diseased lungs correlated to the degree of septal cellularity in nine cases. Two pulmonary sarcoidosis and one end-stage idiopathic pulmonary fibrosis patients presented higher levels of GR than those predicted by the septal cellularity. 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The results showed an increase in the GR content in the diseased lungs correlated to the degree of septal cellularity in nine cases. Two pulmonary sarcoidosis and one end-stage idiopathic pulmonary fibrosis patients presented higher levels of GR than those predicted by the septal cellularity. It was concluded that the GR content of the lungs increases in the course of interstitial diseases, reflecting the number of cells that express cytosolic GR in pulmonary parenchyma.</description><subject>Adult</subject><subject>Aged</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung Diseases - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other techniques and industries</subject><subject>Pneumology</subject><subject>Pneumonia - metabolism</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Receptors, Steroid - metabolism</subject><subject>Regression Analysis</subject><subject>Respiratory Distress Syndrome, Adult - metabolism</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sarcoidosis - metabolism</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQhS1EVZbClRtSDqi3pHFsx84RpVAqVQIhuGI5zrhx5diL7YD67zHsUrggTiPPvDd-8yH0ArcNJlxc6AVSboRoSEMxf4R2eCC4JoySx2jXtrirST90T9DTlO7a8sZDf4pOadsJwbod-jIuyt9Cqqyv8gLVh82twat4X125TQcdYrY62Ln6CBr2OcRqDD6Dz78NY9higiqY6rr0Y8o2W-WqS5tAJXiGToxyCZ4f6xn6_PbNp_FdffP-6np8fVNrSvpcq7kjTPf9wHUJpulk8GS4mGDuuNK0N0KxFpuJTGzqZmzwIAj0ipFZYD4YQ87Q-WHvPoavWyEiV5s0OKc8hC1J3nc9Y5QWYXMQ6hhSimDkPtq13CtxK38Clb-ASiEkkQVoMbw8bt6mFeYH-ZFgmb86zlXSypmovLbpQTZ0bOCC_E_GB04FY3_iLfZ2-W4jyLQq58rf5BDsruD2yv0VTxwMUOh-sxBl0ha8hrmYdZZzsP-67AeV37EF</recordid><startdate>198509</startdate><enddate>198509</enddate><creator>Saidiva, Paulo Hilàrio Nascimento</creator><creator>Mitzi Brentani, Maria</creator><creator>de Carvalho, Carlos R.R.</creator><creator>Otávio, José</creator><creator>Auler, C.</creator><creator>Fernandes Calheiros, Débora</creator><creator>Pacheco, Mércia M.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198509</creationdate><title>Changes in the Pulmonary Glucocorticoid Receptor Content in the Course of Interstitial Disease</title><author>Saidiva, Paulo Hilàrio Nascimento ; Mitzi Brentani, Maria ; de Carvalho, Carlos R.R. ; Otávio, José ; Auler, C. ; Fernandes Calheiros, Débora ; Pacheco, Mércia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-ad235c6697c028c4bf1bf78bed27ac46f8a501fb3b5b2d1f1983e6a53d8179ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Humans</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung Diseases - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other techniques and industries</topic><topic>Pneumology</topic><topic>Pneumonia - metabolism</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Receptors, Steroid - metabolism</topic><topic>Regression Analysis</topic><topic>Respiratory Distress Syndrome, Adult - metabolism</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sarcoidosis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saidiva, Paulo Hilàrio Nascimento</creatorcontrib><creatorcontrib>Mitzi Brentani, Maria</creatorcontrib><creatorcontrib>de Carvalho, Carlos R.R.</creatorcontrib><creatorcontrib>Otávio, José</creatorcontrib><creatorcontrib>Auler, C.</creatorcontrib><creatorcontrib>Fernandes Calheiros, Débora</creatorcontrib><creatorcontrib>Pacheco, Mércia M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saidiva, Paulo Hilàrio Nascimento</au><au>Mitzi Brentani, Maria</au><au>de Carvalho, Carlos R.R.</au><au>Otávio, José</au><au>Auler, C.</au><au>Fernandes Calheiros, Débora</au><au>Pacheco, Mércia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the Pulmonary Glucocorticoid Receptor Content in the Course of Interstitial Disease</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1985-09</date><risdate>1985</risdate><volume>88</volume><issue>3</issue><spage>417</spage><epage>419</epage><pages>417-419</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>The level of cytosolic glucocorticoid receptors (GR) was measured in 12 open-chest lung biopsies of interstitial pulmonary diseases. The results showed an increase in the GR content in the diseased lungs correlated to the degree of septal cellularity in nine cases. Two pulmonary sarcoidosis and one end-stage idiopathic pulmonary fibrosis patients presented higher levels of GR than those predicted by the septal cellularity. It was concluded that the GR content of the lungs increases in the course of interstitial diseases, reflecting the number of cells that express cytosolic GR in pulmonary parenchyma.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>4028852</pmid><doi>10.1378/chest.88.3.417</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1985-09, Vol.88 (3), p.417-419 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Applied sciences Biological and medical sciences Exact sciences and technology Female Humans Lung - metabolism Lung - pathology Lung Diseases - metabolism Male Medical sciences Middle Aged Other techniques and industries Pneumology Pneumonia - metabolism Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Receptors, Glucocorticoid - metabolism Receptors, Steroid - metabolism Regression Analysis Respiratory Distress Syndrome, Adult - metabolism Respiratory system : syndromes and miscellaneous diseases Sarcoidosis - metabolism |
| title | Changes in the Pulmonary Glucocorticoid Receptor Content in the Course of Interstitial Disease |
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