Anterior chemotherapy in esophageal cancer
Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. R...
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| Veröffentlicht in: | Cancer 1985-10, Vol.56 (7), p.1502-1506 |
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| container_title | Cancer |
| container_volume | 56 |
| creator | Advani, Suresh H. Saikia, Tapan K. Swaroop, Shanti Ramakrishnan, Gopal Nair, Chandrika N. Dinshaw, Ketayun A. Sharma, Sanjay Vyas, Jitendra J. Desai, Praful B. |
| description | Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherapy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short‐term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow‐up will help to evaluate the role of front loading chemotherapy on long‐term survival. Cancer 56: 1502‐1506, 1985. |
| doi_str_mv | 10.1002/1097-0142(19851001)56:7<1502::AID-CNCR2820560704>3.0.CO;2-P |
| format | Article |
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Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherapy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short‐term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow‐up will help to evaluate the role of front loading chemotherapy on long‐term survival. Cancer 56: 1502‐1506, 1985.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19851001)56:7<1502::AID-CNCR2820560704>3.0.CO;2-P</identifier><identifier>PMID: 4040800</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chemotherapy ; Cisplatin - therapeutic use ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - radiotherapy ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Middle Aged ; Pharmacology. Drug treatments</subject><ispartof>Cancer, 1985-10, Vol.56 (7), p.1502-1506</ispartof><rights>Copyright © 1985 American Cancer Society</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4984-49d0212e4f53a4ca6c21ec997ce5a4f06bdcd08ff914596f7eedd3a50c041dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8493857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4040800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Advani, Suresh H.</creatorcontrib><creatorcontrib>Saikia, Tapan K.</creatorcontrib><creatorcontrib>Swaroop, Shanti</creatorcontrib><creatorcontrib>Ramakrishnan, Gopal</creatorcontrib><creatorcontrib>Nair, Chandrika N.</creatorcontrib><creatorcontrib>Dinshaw, Ketayun A.</creatorcontrib><creatorcontrib>Sharma, Sanjay</creatorcontrib><creatorcontrib>Vyas, Jitendra J.</creatorcontrib><creatorcontrib>Desai, Praful B.</creatorcontrib><title>Anterior chemotherapy in esophageal cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherapy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short‐term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow‐up will help to evaluate the role of front loading chemotherapy on long‐term survival. Cancer 56: 1502‐1506, 1985.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Cisplatin - therapeutic use</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - radiotherapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherapy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short‐term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow‐up will help to evaluate the role of front loading chemotherapy on long‐term survival. Cancer 56: 1502‐1506, 1985.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4040800</pmid><doi>10.1002/1097-0142(19851001)56:7<1502::AID-CNCR2820560704>3.0.CO;2-P</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Cisplatin - therapeutic use Esophageal Neoplasms - drug therapy Esophageal Neoplasms - radiotherapy Female Follow-Up Studies Humans Male Medical sciences Methotrexate - therapeutic use Middle Aged Pharmacology. Drug treatments |
| title | Anterior chemotherapy in esophageal cancer |
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