The antinociceptive and motivational effects of intranigral injection of opioid agonists
The antinociceptive potency of morphine and the morphine metabolite morphine-6-glucuronide (M6G) was examined after injection into the substantia nigra and periaqueductal gray (PAG) of rats. Both drugs produced antinociception in both sites. The antinociceptive potency of M6G was significantly great...
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| Veröffentlicht in: | Neuropharmacology 1993-12, Vol.32 (12), p.1299-1303 |
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| creator | Baumeister, Alan A. Hurry, Mark Curtis, Will Chaney, Tiffany M. Wolf, Eddie Leoni, Ricky R. |
| description | The antinociceptive potency of morphine and the morphine metabolite morphine-6-glucuronide (M6G) was examined after injection into the substantia nigra and periaqueductal gray (PAG) of rats. Both drugs produced antinociception in both sites. The antinociceptive potency of M6G was significantly greater than morphine in the nigra. There was no difference in the antinociceptive potency of M6G in the nigra and PAG. M6G and other opioids were also examined for motivational effects after intranigral injection. A high dose of intranigral morphine (10.0 nmol) produced a conditioned place preference. No significant motivational effects were produced by 1.0 nmol of M6G,
d-Ala
2,
N-Me-Phe
4, Gly
5-ol-enkephalin (DAGO),
d-Pen
2,
d-Pen
5-enkephalin (DPDPE), or U-50,488H. It is concluded that the substantia nigra plays an important role in opioid antinociception. The role of the nigra in opioid reward is questionable. |
| doi_str_mv | 10.1016/0028-3908(93)90024-W |
| format | Article |
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d-Ala
2,
N-Me-Phe
4, Gly
5-ol-enkephalin (DAGO),
d-Pen
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d-Pen
5-enkephalin (DPDPE), or U-50,488H. It is concluded that the substantia nigra plays an important role in opioid antinociception. The role of the nigra in opioid reward is questionable.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/0028-3908(93)90024-W</identifier><identifier>PMID: 8152521</identifier><identifier>CODEN: NEPHBW</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ; analgesia ; Analgesics ; Analgesics - administration & dosage ; Analgesics - pharmacology ; Analysis of Variance ; Animals ; antinociception ; Biological and medical sciences ; conditioned place preference ; Dose-Response Relationship, Drug ; Enkephalin, Ala-MePhe-Gly ; Enkephalin, D-Penicillamine (2,5) ; Enkephalins - administration & dosage ; Enkephalins - pharmacology ; Male ; Medical sciences ; Microinjections ; morphine ; Morphine - administration & dosage ; Morphine - pharmacology ; Morphine Derivatives - administration & dosage ; Morphine Derivatives - pharmacology ; Motivation ; Neuropharmacology ; opioids ; Pain - physiopathology ; Periaqueductal Gray - drug effects ; Periaqueductal Gray - physiology ; Pharmacology. Drug treatments ; Pyrrolidines - administration & dosage ; Pyrrolidines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Reward ; Stereotaxic Techniques ; substantia nigra ; Substantia Nigra - drug effects ; Substantia Nigra - physiology ; Time Factors</subject><ispartof>Neuropharmacology, 1993-12, Vol.32 (12), p.1299-1303</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d6fc625ac1124119b1bd50708907e1e0ae5f33f952f6a3f0738f85c80e65d12d3</citedby><cites>FETCH-LOGICAL-c417t-d6fc625ac1124119b1bd50708907e1e0ae5f33f952f6a3f0738f85c80e65d12d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0028-3908(93)90024-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3854966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8152521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baumeister, Alan A.</creatorcontrib><creatorcontrib>Hurry, Mark</creatorcontrib><creatorcontrib>Curtis, Will</creatorcontrib><creatorcontrib>Chaney, Tiffany M.</creatorcontrib><creatorcontrib>Wolf, Eddie</creatorcontrib><creatorcontrib>Leoni, Ricky R.</creatorcontrib><title>The antinociceptive and motivational effects of intranigral injection of opioid agonists</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>The antinociceptive potency of morphine and the morphine metabolite morphine-6-glucuronide (M6G) was examined after injection into the substantia nigra and periaqueductal gray (PAG) of rats. Both drugs produced antinociception in both sites. The antinociceptive potency of M6G was significantly greater than morphine in the nigra. There was no difference in the antinociceptive potency of M6G in the nigra and PAG. M6G and other opioids were also examined for motivational effects after intranigral injection. A high dose of intranigral morphine (10.0 nmol) produced a conditioned place preference. No significant motivational effects were produced by 1.0 nmol of M6G,
d-Ala
2,
N-Me-Phe
4, Gly
5-ol-enkephalin (DAGO),
d-Pen
2,
d-Pen
5-enkephalin (DPDPE), or U-50,488H. It is concluded that the substantia nigra plays an important role in opioid antinociception. The role of the nigra in opioid reward is questionable.</description><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</subject><subject>analgesia</subject><subject>Analgesics</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>antinociception</subject><subject>Biological and medical sciences</subject><subject>conditioned place preference</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Enkephalin, D-Penicillamine (2,5)</subject><subject>Enkephalins - administration & dosage</subject><subject>Enkephalins - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microinjections</subject><subject>morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - pharmacology</subject><subject>Morphine Derivatives - administration & dosage</subject><subject>Morphine Derivatives - pharmacology</subject><subject>Motivation</subject><subject>Neuropharmacology</subject><subject>opioids</subject><subject>Pain - physiopathology</subject><subject>Periaqueductal Gray - drug effects</subject><subject>Periaqueductal Gray - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrrolidines - administration & dosage</subject><subject>Pyrrolidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reward</subject><subject>Stereotaxic Techniques</subject><subject>substantia nigra</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - physiology</subject><subject>Time Factors</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9rVDEQx4ModVv9DxTeQYoeXp28vPy6CFKsCgUvLfUWssmkprxN1uRtwf--ee6yRz0lM9_PDMOHkDcULihQ8RFgUD3ToN5r9kG3auzvnpEVVZL1EsT4nKyOyEtyWusDAIyKqhNyoigf-EBX5OfNL-xsmmPKLjrczvFxqX23ye1r55iTnToMAd1cuxy6mOZiU7wvrR3TQ2s3ZAnyNuboO3ufU6xzfUVeBDtVfH14z8jt1Zeby2_99Y-v3y8_X_dupHLuvQhODNw6SoeRUr2ma89BgtIgkSJY5IGxoPkQhGUBJFNBcacABfd08OyMnO_3bkv-vcM6m02sDqfJJsy7aqQYxAhS_xekQkoGwBo47kFXcq0Fg9mWuLHlj6FgFvNm0WoWrUYz89e8uWtjbw_7d-sN-uPQQXXL3x1yW52dQrPoYj1iTPFRC9GwT3sMm7THiMVUFzE59LE02cbn-O87ngC3a5-v</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Baumeister, Alan A.</creator><creator>Hurry, Mark</creator><creator>Curtis, Will</creator><creator>Chaney, Tiffany M.</creator><creator>Wolf, Eddie</creator><creator>Leoni, Ricky R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>The antinociceptive and motivational effects of intranigral injection of opioid agonists</title><author>Baumeister, Alan A. ; Hurry, Mark ; Curtis, Will ; Chaney, Tiffany M. ; Wolf, Eddie ; Leoni, Ricky R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d6fc625ac1124119b1bd50708907e1e0ae5f33f952f6a3f0738f85c80e65d12d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</topic><topic>analgesia</topic><topic>Analgesics</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>antinociception</topic><topic>Biological and medical sciences</topic><topic>conditioned place preference</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Enkephalin, D-Penicillamine (2,5)</topic><topic>Enkephalins - administration & dosage</topic><topic>Enkephalins - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microinjections</topic><topic>morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - pharmacology</topic><topic>Morphine Derivatives - administration & dosage</topic><topic>Morphine Derivatives - pharmacology</topic><topic>Motivation</topic><topic>Neuropharmacology</topic><topic>opioids</topic><topic>Pain - physiopathology</topic><topic>Periaqueductal Gray - drug effects</topic><topic>Periaqueductal Gray - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrrolidines - administration & dosage</topic><topic>Pyrrolidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reward</topic><topic>Stereotaxic Techniques</topic><topic>substantia nigra</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baumeister, Alan A.</creatorcontrib><creatorcontrib>Hurry, Mark</creatorcontrib><creatorcontrib>Curtis, Will</creatorcontrib><creatorcontrib>Chaney, Tiffany M.</creatorcontrib><creatorcontrib>Wolf, Eddie</creatorcontrib><creatorcontrib>Leoni, Ricky R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baumeister, Alan A.</au><au>Hurry, Mark</au><au>Curtis, Will</au><au>Chaney, Tiffany M.</au><au>Wolf, Eddie</au><au>Leoni, Ricky R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antinociceptive and motivational effects of intranigral injection of opioid agonists</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>32</volume><issue>12</issue><spage>1299</spage><epage>1303</epage><pages>1299-1303</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><coden>NEPHBW</coden><abstract>The antinociceptive potency of morphine and the morphine metabolite morphine-6-glucuronide (M6G) was examined after injection into the substantia nigra and periaqueductal gray (PAG) of rats. Both drugs produced antinociception in both sites. The antinociceptive potency of M6G was significantly greater than morphine in the nigra. There was no difference in the antinociceptive potency of M6G in the nigra and PAG. M6G and other opioids were also examined for motivational effects after intranigral injection. A high dose of intranigral morphine (10.0 nmol) produced a conditioned place preference. No significant motivational effects were produced by 1.0 nmol of M6G,
d-Ala
2,
N-Me-Phe
4, Gly
5-ol-enkephalin (DAGO),
d-Pen
2,
d-Pen
5-enkephalin (DPDPE), or U-50,488H. It is concluded that the substantia nigra plays an important role in opioid antinociception. The role of the nigra in opioid reward is questionable.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8152521</pmid><doi>10.1016/0028-3908(93)90024-W</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3908 |
| ispartof | Neuropharmacology, 1993-12, Vol.32 (12), p.1299-1303 |
| issn | 0028-3908 1873-7064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76264079 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer analgesia Analgesics Analgesics - administration & dosage Analgesics - pharmacology Analysis of Variance Animals antinociception Biological and medical sciences conditioned place preference Dose-Response Relationship, Drug Enkephalin, Ala-MePhe-Gly Enkephalin, D-Penicillamine (2,5) Enkephalins - administration & dosage Enkephalins - pharmacology Male Medical sciences Microinjections morphine Morphine - administration & dosage Morphine - pharmacology Morphine Derivatives - administration & dosage Morphine Derivatives - pharmacology Motivation Neuropharmacology opioids Pain - physiopathology Periaqueductal Gray - drug effects Periaqueductal Gray - physiology Pharmacology. Drug treatments Pyrrolidines - administration & dosage Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Reward Stereotaxic Techniques substantia nigra Substantia Nigra - drug effects Substantia Nigra - physiology Time Factors |
| title | The antinociceptive and motivational effects of intranigral injection of opioid agonists |
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