Nuclear magnetic resonance studies of fracture repair
High-resolution phosphorus nuclear magnetic resonance spectroscopy was used to monitor noninvasively the local pH changes that occur in vivo throughout fracture repair in rats. During the healing of a fractured shaft of tibia, the pH of the fracture hematoma changed from 7.2 on day two to 7.5 on day...
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| Veröffentlicht in: | Clinical orthopaedics and related research 1985-01, Vol.198 (198), p.297-303 |
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| container_title | Clinical orthopaedics and related research |
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| creator | NEWMAN, R. J DUTHIE, R. B FRANCIS, M. J. O |
| description | High-resolution phosphorus nuclear magnetic resonance spectroscopy was used to monitor noninvasively the local pH changes that occur in vivo throughout fracture repair in rats. During the healing of a fractured shaft of tibia, the pH of the fracture hematoma changed from 7.2 on day two to 7.5 on day 20, i.e., alkaline with respect to the pH of normal extracellular fluid. This did not occur in a hematoma created by the direct injection of blood. Deposition of radio-opaque callus occurred mainly during the alkaline phase. Abnormalities in the control of local pH may be important in the etiology of delayed union, and future forms of local therapy may be usefully directed toward influencing this parameter. |
| doi_str_mv | 10.1097/00003086-198509000-00044 |
| format | Article |
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J ; DUTHIE, R. B ; FRANCIS, M. J. O</creator><creatorcontrib>NEWMAN, R. J ; DUTHIE, R. B ; FRANCIS, M. J. O</creatorcontrib><description>High-resolution phosphorus nuclear magnetic resonance spectroscopy was used to monitor noninvasively the local pH changes that occur in vivo throughout fracture repair in rats. During the healing of a fractured shaft of tibia, the pH of the fracture hematoma changed from 7.2 on day two to 7.5 on day 20, i.e., alkaline with respect to the pH of normal extracellular fluid. This did not occur in a hematoma created by the direct injection of blood. Deposition of radio-opaque callus occurred mainly during the alkaline phase. Abnormalities in the control of local pH may be important in the etiology of delayed union, and future forms of local therapy may be usefully directed toward influencing this parameter.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1097/00003086-198509000-00044</identifier><identifier>PMID: 4028563</identifier><identifier>CODEN: CORTBR</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Hematoma - metabolism ; Hydrogen-Ion Concentration ; Injuries of the limb. Injuries of the spine ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Rats ; Spectrum Analysis ; Tibia - analysis ; Tibial Fractures - metabolism ; Tibial Fractures - physiopathology ; Traumas. 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B</creatorcontrib><creatorcontrib>FRANCIS, M. J. O</creatorcontrib><title>Nuclear magnetic resonance studies of fracture repair</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><description>High-resolution phosphorus nuclear magnetic resonance spectroscopy was used to monitor noninvasively the local pH changes that occur in vivo throughout fracture repair in rats. During the healing of a fractured shaft of tibia, the pH of the fracture hematoma changed from 7.2 on day two to 7.5 on day 20, i.e., alkaline with respect to the pH of normal extracellular fluid. This did not occur in a hematoma created by the direct injection of blood. Deposition of radio-opaque callus occurred mainly during the alkaline phase. Abnormalities in the control of local pH may be important in the etiology of delayed union, and future forms of local therapy may be usefully directed toward influencing this parameter.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Hematoma - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Spectrum Analysis</subject><subject>Tibia - analysis</subject><subject>Tibial Fractures - metabolism</subject><subject>Tibial Fractures - physiopathology</subject><subject>Traumas. 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Injuries of the spine</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Spectrum Analysis</topic><topic>Tibia - analysis</topic><topic>Tibial Fractures - metabolism</topic><topic>Tibial Fractures - physiopathology</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NEWMAN, R. J</creatorcontrib><creatorcontrib>DUTHIE, R. B</creatorcontrib><creatorcontrib>FRANCIS, M. J. 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| identifier | ISSN: 0009-921X |
| ispartof | Clinical orthopaedics and related research, 1985-01, Vol.198 (198), p.297-303 |
| issn | 0009-921X 1528-1132 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Biological and medical sciences Hematoma - metabolism Hydrogen-Ion Concentration Injuries of the limb. Injuries of the spine Magnetic Resonance Spectroscopy Male Medical sciences Rats Spectrum Analysis Tibia - analysis Tibial Fractures - metabolism Tibial Fractures - physiopathology Traumas. Diseases due to physical agents Wound Healing |
| title | Nuclear magnetic resonance studies of fracture repair |
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