Studies on monokines as mediators of the acute phase response: Effects on sialyltransferase, albumin, α 1-acid glycoprotein and β-N-acetylhexosaminidase
Rat peritoneal leukocytes (PEC) were fractionated on Percoll gradients to prepare populations of monocytes/lymphocytes and polymorphonuclear leukocytes; adherent (monocyte enriched) and non-adherent (lymphocytes/polymorphonuclear leukocytes) cells were also isolated from PEC. Cytokines were prepared...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1985-07, Vol.130 (1), p.30-36 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Woloski, B.M.R.N.J. Gospodarek, E. Jamieson, J.C. |
| description | Rat peritoneal leukocytes (PEC) were fractionated on Percoll gradients to prepare populations of monocytes/lymphocytes and polymorphonuclear leukocytes; adherent (monocyte enriched) and non-adherent (lymphocytes/polymorphonuclear leukocytes) cells were also isolated from PEC. Cytokines were prepared from PEC and subfractions and injected into rats to induce the acute phase reactants serum α
1-acid glycoprotein and sialyltransferase; negative acute phase parameters serum albumin and liver hexosaminidase were also assayed. Monocyte derived cytokines (monokines) mimicked the acute phase response of all four parameters
in vivo
. The sialyltransferase isoenzyme that responded to monokine was identified as the Galβ1→4GlcNAcα2→6 isoenzyme. |
| doi_str_mv | 10.1016/0006-291X(85)90377-8 |
| format | Article |
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1-acid glycoprotein and sialyltransferase; negative acute phase parameters serum albumin and liver hexosaminidase were also assayed. Monocyte derived cytokines (monokines) mimicked the acute phase response of all four parameters
in vivo
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1-acid glycoprotein and sialyltransferase; negative acute phase parameters serum albumin and liver hexosaminidase were also assayed. Monocyte derived cytokines (monokines) mimicked the acute phase response of all four parameters
in vivo
. The sialyltransferase isoenzyme that responded to monokine was identified as the Galβ1→4GlcNAcα2→6 isoenzyme.</description><subject>Animals</subject><subject>beta-N-Acetylhexosaminidases</subject><subject>Hexosaminidases - metabolism</subject><subject>Inflammation - physiopathology</subject><subject>Isoenzymes - metabolism</subject><subject>Liver - enzymology</subject><subject>Monocytes - physiology</subject><subject>Monokines</subject><subject>Orosomucoid - blood</subject><subject>Proteins - physiology</subject><subject>Rats</subject><subject>Serum Albumin - metabolism</subject><subject>Sialyltransferases - blood</subject><subject>Substrate Specificity</subject><subject>Transferases - blood</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9Ue2KFDEQDKKce6dvoJBf4sGNpiez2cQfghznBxz6QwX_hWzScaMzyZpkxH0V30If5J7J7N4iNDRNVTVFFSGPgD0DBuI5Y0x0vYIvT-XyXDG-WnXyDlkAU6zrgQ13yeI_5T45LeUbYwCDUCfkhIOAQakF-f2xzi5goSnSKcX0PcR2mEIndMHUlBviad0gNXauSLcbU5BmLNsUC76gV96jrQd5CWbcjTWbWDzmRrugZlzPU4gX9OYPhc7Y4OjXcWfTNqeKIVITHb35271vENbduMFfqZgmCK7JH5B73owFHx73Gfn8-urT5dvu-sObd5evrjsExWtnzWCVd3bdW47SD2vHZBsrwXsPnA_GL6WQZhD9SvRLsFxxUEpwp9jhOCNPbv82Vz9mLFVPoVgcRxMxzUU3lehhWDXi4yNxXrd49DaHyeSdPobZ8Je3ODa3PwNmXWzAaFuSuYWkXQoamN6Xp_fN6H0zWi71oTwt-T_O449k</recordid><startdate>19850716</startdate><enddate>19850716</enddate><creator>Woloski, B.M.R.N.J.</creator><creator>Gospodarek, E.</creator><creator>Jamieson, J.C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19850716</creationdate><title>Studies on monokines as mediators of the acute phase response: Effects on sialyltransferase, albumin, α 1-acid glycoprotein and β-N-acetylhexosaminidase</title><author>Woloski, B.M.R.N.J. ; Gospodarek, E. ; Jamieson, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e193t-ca4c9fdcb2c3e8f4bd08d08c81fff1334af5868a46276251c39319963d901c393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>beta-N-Acetylhexosaminidases</topic><topic>Hexosaminidases - metabolism</topic><topic>Inflammation - physiopathology</topic><topic>Isoenzymes - metabolism</topic><topic>Liver - enzymology</topic><topic>Monocytes - physiology</topic><topic>Monokines</topic><topic>Orosomucoid - blood</topic><topic>Proteins - physiology</topic><topic>Rats</topic><topic>Serum Albumin - metabolism</topic><topic>Sialyltransferases - blood</topic><topic>Substrate Specificity</topic><topic>Transferases - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woloski, B.M.R.N.J.</creatorcontrib><creatorcontrib>Gospodarek, E.</creatorcontrib><creatorcontrib>Jamieson, J.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woloski, B.M.R.N.J.</au><au>Gospodarek, E.</au><au>Jamieson, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on monokines as mediators of the acute phase response: Effects on sialyltransferase, albumin, α 1-acid glycoprotein and β-N-acetylhexosaminidase</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1985-07-16</date><risdate>1985</risdate><volume>130</volume><issue>1</issue><spage>30</spage><epage>36</epage><pages>30-36</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Rat peritoneal leukocytes (PEC) were fractionated on Percoll gradients to prepare populations of monocytes/lymphocytes and polymorphonuclear leukocytes; adherent (monocyte enriched) and non-adherent (lymphocytes/polymorphonuclear leukocytes) cells were also isolated from PEC. Cytokines were prepared from PEC and subfractions and injected into rats to induce the acute phase reactants serum α
1-acid glycoprotein and sialyltransferase; negative acute phase parameters serum albumin and liver hexosaminidase were also assayed. Monocyte derived cytokines (monokines) mimicked the acute phase response of all four parameters
in vivo
. The sialyltransferase isoenzyme that responded to monokine was identified as the Galβ1→4GlcNAcα2→6 isoenzyme.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3161499</pmid><doi>10.1016/0006-291X(85)90377-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1985-07, Vol.130 (1), p.30-36 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals beta-N-Acetylhexosaminidases Hexosaminidases - metabolism Inflammation - physiopathology Isoenzymes - metabolism Liver - enzymology Monocytes - physiology Monokines Orosomucoid - blood Proteins - physiology Rats Serum Albumin - metabolism Sialyltransferases - blood Substrate Specificity Transferases - blood |
| title | Studies on monokines as mediators of the acute phase response: Effects on sialyltransferase, albumin, α 1-acid glycoprotein and β-N-acetylhexosaminidase |
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