Opioid receptor density changes in Alzheimer amygdala and putamen
Since opioids can influence the release of acetylcholine, substance P and a number of other neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined μ, δ and κ opioid receptor binding p...
Gespeichert in:
| Veröffentlicht in: | Brain research 1993-12, Vol.632 (1), p.209-215 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 215 |
|---|---|
| container_issue | 1 |
| container_start_page | 209 |
| container_title | Brain research |
| container_volume | 632 |
| creator | Barg, Jacob Belcheva, Mariana Rowinski, Jan Ho, Andrew Burke, William J. Chung, Hyung. D. Schmidt, Catherine A. Coscia, Carmine J. |
| description | Since opioids can influence the release of acetylcholine, substance P and a number of other neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined μ, δ and κ opioid receptor binding parameters, binding sensitivity to a GTP analog and distribution in amygdala, frontal cortex and putamen of AD brain. Control brains were matched according to age, sex, post-mortem internal and storage time.
K
d
values and GTP analog binding sensitivity did not differ in AD and control brains.
B
max values for μ ([
3H]DAMGE) sites also appeared unaffected by in vitro binding assays. In contrast, κ ([
3H]U69593) and δ ([
3H]DSLET) opioid receptor levels, were significantly changed. In AD amygdala κ
B
max values increased from control levels of 123 ± 12 to 168 ± 13fmol/mg protein, whereas densities of κ and δ sites were decreased from > 94 ± 8 to 48 ± 8 and 102 ± 3.6 to 69 ± 8.5fmol/mg protein, respectively, in putamen. Autoradiography revealed corresponding differences in the distribution of κ opioid receptors. The findings indicated that the κ binding site, which is quantitatively the major opioid receptor class in human brain, undergoes marked changes in AD amygdala and putamen. |
| doi_str_mv | 10.1016/0006-8993(93)91155-L |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76262048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000689939391155L</els_id><sourcerecordid>76262048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-d538bf97e74456ca3e4b53ab517e6d0324913c6759e11848bc5e19ce7fdc04f13</originalsourceid><addsrcrecordid>eNqFkctKxDAUhoMoOo6-gUIXIrqoJk2ay0YYBm8w4EbXIU1ONdKbSSuMT2_LDLNUCITwf-fCF4TOCL4hmPBbjDFPpVL0StFrRUiep6s9NCNSZCnPGN5Hsx1yhI5j_ByflCp8iA4lYSrL1AwtXjrfepcEsND1bUgcNNH368R-mOYdYuKbZFH9fICvISSmXr87U5nENC7pht7U0Jygg9JUEU639xy9Pdy_Lp_S1cvj83KxSi0jok9dTmVRKgGCsZxbQ4EVOTVFTgRwh2nGFKGWi1wBIZLJwuZAlAVROotZSegcXW76dqH9GiD2uvbRQlWZBtohasEznmEm_wUJl1RleALZBrShjTFAqbvgaxPWmmA9KdaTPz3509OZFOvVWHa-7T8UNbhd0dbpmF9scxOtqcpgGuvjDqNSYK6m6XcbDEZp3x6CjtZDY8H58TN67Vr_9x6_XYuWsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16839208</pqid></control><display><type>article</type><title>Opioid receptor density changes in Alzheimer amygdala and putamen</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Barg, Jacob ; Belcheva, Mariana ; Rowinski, Jan ; Ho, Andrew ; Burke, William J. ; Chung, Hyung. D. ; Schmidt, Catherine A. ; Coscia, Carmine J.</creator><creatorcontrib>Barg, Jacob ; Belcheva, Mariana ; Rowinski, Jan ; Ho, Andrew ; Burke, William J. ; Chung, Hyung. D. ; Schmidt, Catherine A. ; Coscia, Carmine J.</creatorcontrib><description>Since opioids can influence the release of acetylcholine, substance P and a number of other neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined μ, δ and κ opioid receptor binding parameters, binding sensitivity to a GTP analog and distribution in amygdala, frontal cortex and putamen of AD brain. Control brains were matched according to age, sex, post-mortem internal and storage time.
K
d
values and GTP analog binding sensitivity did not differ in AD and control brains.
B
max values for μ ([
3H]DAMGE) sites also appeared unaffected by in vitro binding assays. In contrast, κ ([
3H]U69593) and δ ([
3H]DSLET) opioid receptor levels, were significantly changed. In AD amygdala κ
B
max values increased from control levels of 123 ± 12 to 168 ± 13fmol/mg protein, whereas densities of κ and δ sites were decreased from > 94 ± 8 to 48 ± 8 and 102 ± 3.6 to 69 ± 8.5fmol/mg protein, respectively, in putamen. Autoradiography revealed corresponding differences in the distribution of κ opioid receptors. The findings indicated that the κ binding site, which is quantitatively the major opioid receptor class in human brain, undergoes marked changes in AD amygdala and putamen.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)91155-L</identifier><identifier>PMID: 8149229</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer's disease ; Amygdala ; Amygdala - metabolism ; Amygdala - pathology ; Analgesics - metabolism ; Autoradiography ; Benzeneacetamides ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Enkephalin, Ala-MePhe-Gly ; Enkephalin, Leucine - analogs & derivatives ; Enkephalin, Leucine - metabolism ; Enkephalins - metabolism ; Female ; Frontal cortex ; Frontal Lobe - metabolism ; Frontal Lobe - pathology ; GTP analog ; Human brain ; Humans ; Kinetics ; Male ; Medical sciences ; Neurology ; Opioid receptor ; Putamen ; Putamen - metabolism ; Putamen - pathology ; Pyrrolidines - metabolism ; Receptors, Opioid, delta - analysis ; Receptors, Opioid, delta - metabolism ; Receptors, Opioid, kappa - analysis ; Receptors, Opioid, kappa - metabolism ; Receptors, Opioid, mu - analysis ; Receptors, Opioid, mu - metabolism ; Reference Values ; Tritium</subject><ispartof>Brain research, 1993-12, Vol.632 (1), p.209-215</ispartof><rights>1993 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d538bf97e74456ca3e4b53ab517e6d0324913c6759e11848bc5e19ce7fdc04f13</citedby><cites>FETCH-LOGICAL-c417t-d538bf97e74456ca3e4b53ab517e6d0324913c6759e11848bc5e19ce7fdc04f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(93)91155-L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3870698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8149229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barg, Jacob</creatorcontrib><creatorcontrib>Belcheva, Mariana</creatorcontrib><creatorcontrib>Rowinski, Jan</creatorcontrib><creatorcontrib>Ho, Andrew</creatorcontrib><creatorcontrib>Burke, William J.</creatorcontrib><creatorcontrib>Chung, Hyung. D.</creatorcontrib><creatorcontrib>Schmidt, Catherine A.</creatorcontrib><creatorcontrib>Coscia, Carmine J.</creatorcontrib><title>Opioid receptor density changes in Alzheimer amygdala and putamen</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Since opioids can influence the release of acetylcholine, substance P and a number of other neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined μ, δ and κ opioid receptor binding parameters, binding sensitivity to a GTP analog and distribution in amygdala, frontal cortex and putamen of AD brain. Control brains were matched according to age, sex, post-mortem internal and storage time.
K
d
values and GTP analog binding sensitivity did not differ in AD and control brains.
B
max values for μ ([
3H]DAMGE) sites also appeared unaffected by in vitro binding assays. In contrast, κ ([
3H]U69593) and δ ([
3H]DSLET) opioid receptor levels, were significantly changed. In AD amygdala κ
B
max values increased from control levels of 123 ± 12 to 168 ± 13fmol/mg protein, whereas densities of κ and δ sites were decreased from > 94 ± 8 to 48 ± 8 and 102 ± 3.6 to 69 ± 8.5fmol/mg protein, respectively, in putamen. Autoradiography revealed corresponding differences in the distribution of κ opioid receptors. The findings indicated that the κ binding site, which is quantitatively the major opioid receptor class in human brain, undergoes marked changes in AD amygdala and putamen.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Amygdala</subject><subject>Amygdala - metabolism</subject><subject>Amygdala - pathology</subject><subject>Analgesics - metabolism</subject><subject>Autoradiography</subject><subject>Benzeneacetamides</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Enkephalin, Leucine - analogs & derivatives</subject><subject>Enkephalin, Leucine - metabolism</subject><subject>Enkephalins - metabolism</subject><subject>Female</subject><subject>Frontal cortex</subject><subject>Frontal Lobe - metabolism</subject><subject>Frontal Lobe - pathology</subject><subject>GTP analog</subject><subject>Human brain</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Opioid receptor</subject><subject>Putamen</subject><subject>Putamen - metabolism</subject><subject>Putamen - pathology</subject><subject>Pyrrolidines - metabolism</subject><subject>Receptors, Opioid, delta - analysis</subject><subject>Receptors, Opioid, delta - metabolism</subject><subject>Receptors, Opioid, kappa - analysis</subject><subject>Receptors, Opioid, kappa - metabolism</subject><subject>Receptors, Opioid, mu - analysis</subject><subject>Receptors, Opioid, mu - metabolism</subject><subject>Reference Values</subject><subject>Tritium</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoOo6-gUIXIrqoJk2ay0YYBm8w4EbXIU1ONdKbSSuMT2_LDLNUCITwf-fCF4TOCL4hmPBbjDFPpVL0StFrRUiep6s9NCNSZCnPGN5Hsx1yhI5j_ByflCp8iA4lYSrL1AwtXjrfepcEsND1bUgcNNH368R-mOYdYuKbZFH9fICvISSmXr87U5nENC7pht7U0Jygg9JUEU639xy9Pdy_Lp_S1cvj83KxSi0jok9dTmVRKgGCsZxbQ4EVOTVFTgRwh2nGFKGWi1wBIZLJwuZAlAVROotZSegcXW76dqH9GiD2uvbRQlWZBtohasEznmEm_wUJl1RleALZBrShjTFAqbvgaxPWmmA9KdaTPz3509OZFOvVWHa-7T8UNbhd0dbpmF9scxOtqcpgGuvjDqNSYK6m6XcbDEZp3x6CjtZDY8H58TN67Vr_9x6_XYuWsw</recordid><startdate>19931231</startdate><enddate>19931231</enddate><creator>Barg, Jacob</creator><creator>Belcheva, Mariana</creator><creator>Rowinski, Jan</creator><creator>Ho, Andrew</creator><creator>Burke, William J.</creator><creator>Chung, Hyung. D.</creator><creator>Schmidt, Catherine A.</creator><creator>Coscia, Carmine J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19931231</creationdate><title>Opioid receptor density changes in Alzheimer amygdala and putamen</title><author>Barg, Jacob ; Belcheva, Mariana ; Rowinski, Jan ; Ho, Andrew ; Burke, William J. ; Chung, Hyung. D. ; Schmidt, Catherine A. ; Coscia, Carmine J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d538bf97e74456ca3e4b53ab517e6d0324913c6759e11848bc5e19ce7fdc04f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Amygdala</topic><topic>Amygdala - metabolism</topic><topic>Amygdala - pathology</topic><topic>Analgesics - metabolism</topic><topic>Autoradiography</topic><topic>Benzeneacetamides</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Enkephalin, Leucine - analogs & derivatives</topic><topic>Enkephalin, Leucine - metabolism</topic><topic>Enkephalins - metabolism</topic><topic>Female</topic><topic>Frontal cortex</topic><topic>Frontal Lobe - metabolism</topic><topic>Frontal Lobe - pathology</topic><topic>GTP analog</topic><topic>Human brain</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Opioid receptor</topic><topic>Putamen</topic><topic>Putamen - metabolism</topic><topic>Putamen - pathology</topic><topic>Pyrrolidines - metabolism</topic><topic>Receptors, Opioid, delta - analysis</topic><topic>Receptors, Opioid, delta - metabolism</topic><topic>Receptors, Opioid, kappa - analysis</topic><topic>Receptors, Opioid, kappa - metabolism</topic><topic>Receptors, Opioid, mu - analysis</topic><topic>Receptors, Opioid, mu - metabolism</topic><topic>Reference Values</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barg, Jacob</creatorcontrib><creatorcontrib>Belcheva, Mariana</creatorcontrib><creatorcontrib>Rowinski, Jan</creatorcontrib><creatorcontrib>Ho, Andrew</creatorcontrib><creatorcontrib>Burke, William J.</creatorcontrib><creatorcontrib>Chung, Hyung. D.</creatorcontrib><creatorcontrib>Schmidt, Catherine A.</creatorcontrib><creatorcontrib>Coscia, Carmine J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barg, Jacob</au><au>Belcheva, Mariana</au><au>Rowinski, Jan</au><au>Ho, Andrew</au><au>Burke, William J.</au><au>Chung, Hyung. D.</au><au>Schmidt, Catherine A.</au><au>Coscia, Carmine J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opioid receptor density changes in Alzheimer amygdala and putamen</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1993-12-31</date><risdate>1993</risdate><volume>632</volume><issue>1</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Since opioids can influence the release of acetylcholine, substance P and a number of other neurotransmitter that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined μ, δ and κ opioid receptor binding parameters, binding sensitivity to a GTP analog and distribution in amygdala, frontal cortex and putamen of AD brain. Control brains were matched according to age, sex, post-mortem internal and storage time.
K
d
values and GTP analog binding sensitivity did not differ in AD and control brains.
B
max values for μ ([
3H]DAMGE) sites also appeared unaffected by in vitro binding assays. In contrast, κ ([
3H]U69593) and δ ([
3H]DSLET) opioid receptor levels, were significantly changed. In AD amygdala κ
B
max values increased from control levels of 123 ± 12 to 168 ± 13fmol/mg protein, whereas densities of κ and δ sites were decreased from > 94 ± 8 to 48 ± 8 and 102 ± 3.6 to 69 ± 8.5fmol/mg protein, respectively, in putamen. Autoradiography revealed corresponding differences in the distribution of κ opioid receptors. The findings indicated that the κ binding site, which is quantitatively the major opioid receptor class in human brain, undergoes marked changes in AD amygdala and putamen.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8149229</pmid><doi>10.1016/0006-8993(93)91155-L</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1993-12, Vol.632 (1), p.209-215 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76262048 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amygdala Amygdala - metabolism Amygdala - pathology Analgesics - metabolism Autoradiography Benzeneacetamides Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enkephalin, Ala-MePhe-Gly Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - metabolism Enkephalins - metabolism Female Frontal cortex Frontal Lobe - metabolism Frontal Lobe - pathology GTP analog Human brain Humans Kinetics Male Medical sciences Neurology Opioid receptor Putamen Putamen - metabolism Putamen - pathology Pyrrolidines - metabolism Receptors, Opioid, delta - analysis Receptors, Opioid, delta - metabolism Receptors, Opioid, kappa - analysis Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - analysis Receptors, Opioid, mu - metabolism Reference Values Tritium |
| title | Opioid receptor density changes in Alzheimer amygdala and putamen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A01%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Opioid%20receptor%20density%20changes%20in%20Alzheimer%20amygdala%20and%20putamen&rft.jtitle=Brain%20research&rft.au=Barg,%20Jacob&rft.date=1993-12-31&rft.volume=632&rft.issue=1&rft.spage=209&rft.epage=215&rft.pages=209-215&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/0006-8993(93)91155-L&rft_dat=%3Cproquest_cross%3E76262048%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16839208&rft_id=info:pmid/8149229&rft_els_id=000689939391155L&rfr_iscdi=true |