Cellular topoisomerase I activity associated with HIV-1

Topoisomerase I activity was detected in detergent-disrupted human immunodeficiency virus type 1 (HIV-1) particles. The enzyme did not require ATP for its conversion of SC DNA to an RC form, had divalent cation requirements similar to those of eukaryotic topoisomerase I, and was significantly inhibi...

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Veröffentlicht in:	AIDS research and human retroviruses 1993-12, Vol.9 (12), p.1245-1250
Hauptverfasser:	Jardine, D, Tachedjian, G, Locarnini, S, Birch, C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Blotting, Western Camptothecin - pharmacology Cell Line Consensus Sequence DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism HIV Infections - enzymology HIV Infections - microbiology HIV-1 - enzymology HIV-1 - genetics HIV-1 - isolation & purification human immunodeficiency virus 1 Humans Molecular Sequence Data Topoisomerase I Inhibitors Virus Replication - drug effects
Online-Zugang:	Volltext
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