Uptake of 2-β- d-ribofuranosylthiazole-4-carboxamide (Tiazofurin) and analogues by the facilitated transport mechanism of erythrocytes

Tiazofurin (TR), a new antitumor agent, enters human erythrocytes by utilizing their facilitated nucleoside transport system. TR competes with endogenous nucleosides for this transport mechanism, thereby reducing nucleoside uptake into the cells. Pre-incubation of erythrocytes for 10 min at 22°C wit...

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