Platelet von Willebrand factor: Comparison with plasma von Willebrand factor
Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that 1) the multimeric organization was different, 2) larger multimers were present, and 3) the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were sim...
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| Veröffentlicht in: | Thrombosis research 1985-06, Vol.38 (6), p.623-633 |
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| container_end_page | 633 |
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| container_title | Thrombosis research |
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| creator | Gralnick, Harvey R. Williams, Sybil B. McKeown, Laurie P. Krizek, Dennis M. Shafer, Brenda C. Rick, Margaret E. |
| description | Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that 1) the multimeric organization was different, 2) larger multimers were present, and 3) the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were similar in their antigenic reactivity in the electroimmunoassay and by liquid phase radioimmunoassay. The amount of vWf activity in large platelets was significantly higher than in normal platelets while the antigen content, although somewhat higher, was not significant. These studies show differences between normal platelet and plasma vWf, and also suggest that platelet size must be considered when platelet vWf is measured in disease states. |
| doi_str_mv | 10.1016/0049-3848(85)90205-1 |
| format | Article |
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The platelet vWf was different from plasma vWf in that 1) the multimeric organization was different, 2) larger multimers were present, and 3) the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were similar in their antigenic reactivity in the electroimmunoassay and by liquid phase radioimmunoassay. The amount of vWf activity in large platelets was significantly higher than in normal platelets while the antigen content, although somewhat higher, was not significant. These studies show differences between normal platelet and plasma vWf, and also suggest that platelet size must be considered when platelet vWf is measured in disease states.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(85)90205-1</identifier><identifier>PMID: 3927508</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Antigens - analysis ; Biological and medical sciences ; Blood Coagulation Factors - analysis ; Blood coagulation. Blood cells ; Blood Platelets - analysis ; Blood Protein Electrophoresis ; Coagulation factors ; Factor VIII - analysis ; Factor VIII - immunology ; Fundamental and applied biological sciences. Psychology ; Humans ; Molecular and cellular biology ; Molecular Weight ; plasma von Willebrand factor ; platelet size ; Platelet von Willebrand factor ; Radioimmunoassay ; von Willebrand Factor - analysis</subject><ispartof>Thrombosis research, 1985-06, Vol.38 (6), p.623-633</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-b173b62b491a68c25c1c2e130a77c09d236a012368ba2d2a44e678e13ed34a393</citedby><cites>FETCH-LOGICAL-c301t-b173b62b491a68c25c1c2e130a77c09d236a012368ba2d2a44e678e13ed34a393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(85)90205-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8590340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3927508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gralnick, Harvey R.</creatorcontrib><creatorcontrib>Williams, Sybil B.</creatorcontrib><creatorcontrib>McKeown, Laurie P.</creatorcontrib><creatorcontrib>Krizek, Dennis M.</creatorcontrib><creatorcontrib>Shafer, Brenda C.</creatorcontrib><creatorcontrib>Rick, Margaret E.</creatorcontrib><title>Platelet von Willebrand factor: Comparison with plasma von Willebrand factor</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that 1) the multimeric organization was different, 2) larger multimers were present, and 3) the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were similar in their antigenic reactivity in the electroimmunoassay and by liquid phase radioimmunoassay. The amount of vWf activity in large platelets was significantly higher than in normal platelets while the antigen content, although somewhat higher, was not significant. These studies show differences between normal platelet and plasma vWf, and also suggest that platelet size must be considered when platelet vWf is measured in disease states.</description><subject>Antigens - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - analysis</subject><subject>Blood Protein Electrophoresis</subject><subject>Coagulation factors</subject><subject>Factor VIII - analysis</subject><subject>Factor VIII - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>plasma von Willebrand factor</subject><subject>platelet size</subject><subject>Platelet von Willebrand factor</subject><subject>Radioimmunoassay</subject><subject>von Willebrand Factor - analysis</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoO4rOOu_0ChDyJ66DWfnWQPggzqLgzoYcVjqE5XYyT9YdKzi__ejNPMSfZSdXiftygeQl4yesUoa95TKm0tjDRvjXpnKaeqZk_Ihhltay41f0o2J-QZeZ7zL0qZZladk3NhuVbUbMjuW4QFIy7V_TRWP0KM2CYYu6oHv0zputpOwwwp5JI-hOVnNUfIA_yfviRnPcSML9Z9Qb5__nS3val3X7_cbj_uai8oW-qWadE2vJWWQWM8V555jkxQ0NpT23HRAGVlmhZ4x0FKbLQpAHZCgrDigrw53p3T9HuPeXFDyB5jhBGnfXa64UoyLQsoj6BPU84JezenMED64xh1B4nuYMgdDDmj3D-JjpXaq_X-vh2wO5VWayV_veaQPcS-KPAhnzCjLBWSFuzDEcPi4j5gctkHHD12IaFfXDeFx__4C_kujI8</recordid><startdate>19850615</startdate><enddate>19850615</enddate><creator>Gralnick, Harvey R.</creator><creator>Williams, Sybil B.</creator><creator>McKeown, Laurie P.</creator><creator>Krizek, Dennis M.</creator><creator>Shafer, Brenda C.</creator><creator>Rick, Margaret E.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850615</creationdate><title>Platelet von Willebrand factor: Comparison with plasma von Willebrand factor</title><author>Gralnick, Harvey R. ; Williams, Sybil B. ; McKeown, Laurie P. ; Krizek, Dennis M. ; Shafer, Brenda C. ; Rick, Margaret E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-b173b62b491a68c25c1c2e130a77c09d236a012368ba2d2a44e678e13ed34a393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antigens - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - analysis</topic><topic>Blood Protein Electrophoresis</topic><topic>Coagulation factors</topic><topic>Factor VIII - analysis</topic><topic>Factor VIII - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular Weight</topic><topic>plasma von Willebrand factor</topic><topic>platelet size</topic><topic>Platelet von Willebrand factor</topic><topic>Radioimmunoassay</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gralnick, Harvey R.</creatorcontrib><creatorcontrib>Williams, Sybil B.</creatorcontrib><creatorcontrib>McKeown, Laurie P.</creatorcontrib><creatorcontrib>Krizek, Dennis M.</creatorcontrib><creatorcontrib>Shafer, Brenda C.</creatorcontrib><creatorcontrib>Rick, Margaret E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gralnick, Harvey R.</au><au>Williams, Sybil B.</au><au>McKeown, Laurie P.</au><au>Krizek, Dennis M.</au><au>Shafer, Brenda C.</au><au>Rick, Margaret E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet von Willebrand factor: Comparison with plasma von Willebrand factor</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1985-06-15</date><risdate>1985</risdate><volume>38</volume><issue>6</issue><spage>623</spage><epage>633</epage><pages>623-633</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that 1) the multimeric organization was different, 2) larger multimers were present, and 3) the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were similar in their antigenic reactivity in the electroimmunoassay and by liquid phase radioimmunoassay. The amount of vWf activity in large platelets was significantly higher than in normal platelets while the antigen content, although somewhat higher, was not significant. These studies show differences between normal platelet and plasma vWf, and also suggest that platelet size must be considered when platelet vWf is measured in disease states.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3927508</pmid><doi>10.1016/0049-3848(85)90205-1</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 1985-06, Vol.38 (6), p.623-633 |
| issn | 0049-3848 1879-2472 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antigens - analysis Biological and medical sciences Blood Coagulation Factors - analysis Blood coagulation. Blood cells Blood Platelets - analysis Blood Protein Electrophoresis Coagulation factors Factor VIII - analysis Factor VIII - immunology Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Weight plasma von Willebrand factor platelet size Platelet von Willebrand factor Radioimmunoassay von Willebrand Factor - analysis |
| title | Platelet von Willebrand factor: Comparison with plasma von Willebrand factor |
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