Haematological manifestations of systemic lupus erythematosus
Haematological involvement is common in systemic lupus erythematosus (SLE). Whilst anaemia is most often due to chronic disease, other causes such as autoimmune haemolytic anaemia and hypoplastic anaemia need to be considered. The increased risk of infection in patients with SLE is due in part to ch...
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| Veröffentlicht in: | Blood reviews 1993-12, Vol.7 (4), p.199-207 |
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| container_title | Blood reviews |
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| creator | Keeling, D.M Isenberg, D.A |
| description | Haematological involvement is common in systemic lupus erythematosus (SLE). Whilst anaemia is most often due to chronic disease, other causes such as autoimmune haemolytic anaemia and hypoplastic anaemia need to be considered. The increased risk of infection in patients with SLE is due in part to changes in the white blood cells though treatments do not yet aim to modify these.
Thrombocytopenia occurs frequently and is almost invariably autoimmune. It is often of little consequence, but may occasionally be severe and serious, requiring aggressive treatment. Patients with SLE have an increased risk of thrombosis, increased further in the presence of antiphospholipid antibodies (aPL). Changes in the haemostatic system and new insights into the nature of aPL are described. |
| doi_str_mv | 10.1016/0268-960X(93)90006-P |
| format | Article |
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Thrombocytopenia occurs frequently and is almost invariably autoimmune. It is often of little consequence, but may occasionally be severe and serious, requiring aggressive treatment. Patients with SLE have an increased risk of thrombosis, increased further in the presence of antiphospholipid antibodies (aPL). Changes in the haemostatic system and new insights into the nature of aPL are described.</description><identifier>ISSN: 0268-960X</identifier><identifier>EISSN: 1532-1681</identifier><identifier>DOI: 10.1016/0268-960X(93)90006-P</identifier><identifier>PMID: 8130682</identifier><language>eng</language><publisher>Kent: Elsevier Ltd</publisher><subject>Anemia - etiology ; Antiphospholipid Syndrome - complications ; Autoantibodies - immunology ; Autoimmune Diseases - blood ; Autoimmune Diseases - complications ; Biological and medical sciences ; Disease Susceptibility ; Hemostasis ; Humans ; Infection - etiology ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - complications ; Lymphopenia - etiology ; Medical sciences ; Neutropenia - etiology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Thrombocytopenia - etiology ; Thrombocytopenia - therapy ; Thrombosis - drug therapy ; Thrombosis - etiology</subject><ispartof>Blood reviews, 1993-12, Vol.7 (4), p.199-207</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-460b5879fb94b07a4597e41bd70886e776d16943872ddfe45691d2b481113acf3</citedby><cites>FETCH-LOGICAL-c437t-460b5879fb94b07a4597e41bd70886e776d16943872ddfe45691d2b481113acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0268-960X(93)90006-P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3872335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8130682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keeling, D.M</creatorcontrib><creatorcontrib>Isenberg, D.A</creatorcontrib><title>Haematological manifestations of systemic lupus erythematosus</title><title>Blood reviews</title><addtitle>Blood Rev</addtitle><description>Haematological involvement is common in systemic lupus erythematosus (SLE). Whilst anaemia is most often due to chronic disease, other causes such as autoimmune haemolytic anaemia and hypoplastic anaemia need to be considered. The increased risk of infection in patients with SLE is due in part to changes in the white blood cells though treatments do not yet aim to modify these.
Thrombocytopenia occurs frequently and is almost invariably autoimmune. It is often of little consequence, but may occasionally be severe and serious, requiring aggressive treatment. Patients with SLE have an increased risk of thrombosis, increased further in the presence of antiphospholipid antibodies (aPL). Changes in the haemostatic system and new insights into the nature of aPL are described.</description><subject>Anemia - etiology</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - complications</subject><subject>Biological and medical sciences</subject><subject>Disease Susceptibility</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Infection - etiology</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lymphopenia - etiology</subject><subject>Medical sciences</subject><subject>Neutropenia - etiology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Thrombocytopenia - etiology</subject><subject>Thrombocytopenia - therapy</subject><subject>Thrombosis - drug therapy</subject><subject>Thrombosis - etiology</subject><issn>0268-960X</issn><issn>1532-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhoMoery8gUIXIrqoJk2ay0JBxBsIulBwF9J0qpFejplWOG9v6zmcpatZzPfP_HyEHDJ6ziiTFzSTOjWSvp8afmYopTJ92SAzlvMsZVKzTTJbIztkF_FrZAyXaptsa8ap1NmMXD44aFzf1d1H8K5OGteGCrB3fehaTLoqwQX20ASf1MN8wATiov_8i-CA-2SrcjXCwWrukbe729ebh_Tp-f7x5vop9YKrPhWSFrlWpiqMKKhyIjcKBCtKRbWWoJQsmTSCa5WVZQUil4aVWSE0Y4w7X_E9crK8O4_d9zDWs01AD3XtWugGtEpmORUqH0GxBH3sECNUdh5D4-LCMmona3ZSYicl1nD7Z82-jLGj1f2haKBch1aaxv3xau9wtFRF1_qAa2wqzvn0_WqJwejiJ0C06AO0HsoQwfe27ML_PX4BjCyI2w</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Keeling, D.M</creator><creator>Isenberg, D.A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Haematological manifestations of systemic lupus erythematosus</title><author>Keeling, D.M ; Isenberg, D.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-460b5879fb94b07a4597e41bd70886e776d16943872ddfe45691d2b481113acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anemia - etiology</topic><topic>Antiphospholipid Syndrome - complications</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - complications</topic><topic>Biological and medical sciences</topic><topic>Disease Susceptibility</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Infection - etiology</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lymphopenia - etiology</topic><topic>Medical sciences</topic><topic>Neutropenia - etiology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Thrombocytopenia - etiology</topic><topic>Thrombocytopenia - therapy</topic><topic>Thrombosis - drug therapy</topic><topic>Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keeling, D.M</creatorcontrib><creatorcontrib>Isenberg, D.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keeling, D.M</au><au>Isenberg, D.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haematological manifestations of systemic lupus erythematosus</atitle><jtitle>Blood reviews</jtitle><addtitle>Blood Rev</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>7</volume><issue>4</issue><spage>199</spage><epage>207</epage><pages>199-207</pages><issn>0268-960X</issn><eissn>1532-1681</eissn><abstract>Haematological involvement is common in systemic lupus erythematosus (SLE). Whilst anaemia is most often due to chronic disease, other causes such as autoimmune haemolytic anaemia and hypoplastic anaemia need to be considered. The increased risk of infection in patients with SLE is due in part to changes in the white blood cells though treatments do not yet aim to modify these.
Thrombocytopenia occurs frequently and is almost invariably autoimmune. It is often of little consequence, but may occasionally be severe and serious, requiring aggressive treatment. Patients with SLE have an increased risk of thrombosis, increased further in the presence of antiphospholipid antibodies (aPL). Changes in the haemostatic system and new insights into the nature of aPL are described.</abstract><cop>Kent</cop><pub>Elsevier Ltd</pub><pmid>8130682</pmid><doi>10.1016/0268-960X(93)90006-P</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-960X |
| ispartof | Blood reviews, 1993-12, Vol.7 (4), p.199-207 |
| issn | 0268-960X 1532-1681 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anemia - etiology Antiphospholipid Syndrome - complications Autoantibodies - immunology Autoimmune Diseases - blood Autoimmune Diseases - complications Biological and medical sciences Disease Susceptibility Hemostasis Humans Infection - etiology Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Lymphopenia - etiology Medical sciences Neutropenia - etiology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Thrombocytopenia - etiology Thrombocytopenia - therapy Thrombosis - drug therapy Thrombosis - etiology |
| title | Haematological manifestations of systemic lupus erythematosus |
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