Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig
The effects of debrisoquin, administered daily for 4 days to rats (40 mg kg , i.p.) and guinea pigs (4 mg kg , i.p.), were determined for urinary excretion of several acidic and neutral amine metabolites, including the norepinephrine metabolites, 3-methoxy-4-hydroxyphenethylene glycol (MHPG) and van...
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| Veröffentlicht in: | Biochemical pharmacology 1985-08, Vol.34 (16), p.2911-2916 |
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| creator | Edwards, David J. Ravitch, Joshua Knopf, Steven |
| description | The effects of debrisoquin, administered daily for 4 days to rats (40
mg
kg
, i.p.) and guinea pigs (4
mg
kg
, i.p.), were determined for urinary excretion of several acidic and neutral amine metabolites, including the norepinephrine metabolites, 3-methoxy-4-hydroxyphenethylene glycol (MHPG) and vanillylmandelic acid (VMA), the dopamine metabolites, 3,4-dihydroxyphenethanol (DHPE), 3-methoxy-4-hydroxyphenethanol (MHPE), and homovanillic acid (HVA), and the octopamine metabolite,
p-hydroxyphenylglycol (pHPG). The excretion of MHPG was reduced to 32% of control in rats and to 46% in guinea pigs, HVA was reduced to 64 and 80% in these two species, respectively, and MHPE was lowered to 59% of control in the rat but was not affected in the guinea pig. DHPE and pHPG were not altered significantly in either species. VMA was a minor metabolite in both species, being less than 6% of MHPG, and its formation was blocked only partially (rat) or not at all (guinea pig) by debrisoquin. The data refute the idea based on previous
in vitro studies that VMA is a major metabolite of norepinephrine in the periphery of the guinea pig as it is in man. |
| doi_str_mv | 10.1016/0006-2952(85)90015-2 |
| format | Article |
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mg
kg
, i.p.) and guinea pigs (4
mg
kg
, i.p.), were determined for urinary excretion of several acidic and neutral amine metabolites, including the norepinephrine metabolites, 3-methoxy-4-hydroxyphenethylene glycol (MHPG) and vanillylmandelic acid (VMA), the dopamine metabolites, 3,4-dihydroxyphenethanol (DHPE), 3-methoxy-4-hydroxyphenethanol (MHPE), and homovanillic acid (HVA), and the octopamine metabolite,
p-hydroxyphenylglycol (pHPG). The excretion of MHPG was reduced to 32% of control in rats and to 46% in guinea pigs, HVA was reduced to 64 and 80% in these two species, respectively, and MHPE was lowered to 59% of control in the rat but was not affected in the guinea pig. DHPE and pHPG were not altered significantly in either species. VMA was a minor metabolite in both species, being less than 6% of MHPG, and its formation was blocked only partially (rat) or not at all (guinea pig) by debrisoquin. The data refute the idea based on previous
in vitro studies that VMA is a major metabolite of norepinephrine in the periphery of the guinea pig as it is in man.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(85)90015-2</identifier><identifier>PMID: 3896245</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3-Methoxy-4-hydroxyphenylethanol - metabolism ; Amines - metabolism ; Animals ; Biological and medical sciences ; Catecholamines - metabolism ; Debrisoquin - pharmacology ; Dose-Response Relationship, Drug ; General pharmacology ; Guinea Pigs ; Isoquinolines - pharmacology ; Male ; Medical sciences ; Methoxyhydroxyphenylglycol - metabolism ; Monoamine Oxidase Inhibitors - pharmacology ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Vanilmandelic Acid - metabolism</subject><ispartof>Biochemical pharmacology, 1985-08, Vol.34 (16), p.2911-2916</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-8de0ecfee8bc9e002e4031fa98742af1fefe5bc4b4c0112f1cbbfeb6454740cb3</citedby><cites>FETCH-LOGICAL-c386t-8de0ecfee8bc9e002e4031fa98742af1fefe5bc4b4c0112f1cbbfeb6454740cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(85)90015-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8623530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3896245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edwards, David J.</creatorcontrib><creatorcontrib>Ravitch, Joshua</creatorcontrib><creatorcontrib>Knopf, Steven</creatorcontrib><title>Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The effects of debrisoquin, administered daily for 4 days to rats (40
mg
kg
, i.p.) and guinea pigs (4
mg
kg
, i.p.), were determined for urinary excretion of several acidic and neutral amine metabolites, including the norepinephrine metabolites, 3-methoxy-4-hydroxyphenethylene glycol (MHPG) and vanillylmandelic acid (VMA), the dopamine metabolites, 3,4-dihydroxyphenethanol (DHPE), 3-methoxy-4-hydroxyphenethanol (MHPE), and homovanillic acid (HVA), and the octopamine metabolite,
p-hydroxyphenylglycol (pHPG). The excretion of MHPG was reduced to 32% of control in rats and to 46% in guinea pigs, HVA was reduced to 64 and 80% in these two species, respectively, and MHPE was lowered to 59% of control in the rat but was not affected in the guinea pig. DHPE and pHPG were not altered significantly in either species. VMA was a minor metabolite in both species, being less than 6% of MHPG, and its formation was blocked only partially (rat) or not at all (guinea pig) by debrisoquin. The data refute the idea based on previous
in vitro studies that VMA is a major metabolite of norepinephrine in the periphery of the guinea pig as it is in man.</description><subject>3-Methoxy-4-hydroxyphenylethanol - metabolism</subject><subject>Amines - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Debrisoquin - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>Isoquinolines - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxyhydroxyphenylglycol - metabolism</subject><subject>Monoamine Oxidase Inhibitors - pharmacology</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vanilmandelic Acid - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFrHSEUhaW0JK9J_0EDLkJpF5Ooo_OcTaCEtAkEsmnXoneuiWVmfFFfSP99fZnHW3Ylx_Odi_dIyGfOLjjj3SVjrGtEr8RXrb71jHHViHdkxfW6rdedfk9WB-SYfMz5z07qjh-Ro1b3nZBqRaYb7xFKptHTAV0KOT5vw0zjTMsTUnyFhCVUVX2wBeEpjnYKM1I7DzRCiZtFTlisi2MomGlYwsmWN-qxDkRLN-HxlHzwdsz4aX-ekN8_bn5d3zb3Dz_vrr_fN9DqrjR6QIbgEbWDHhkTKFnLve31WgrruUePyoF0EhjnwnNwzqPrpJJrycC1J-TLMneT6jqYi5lCBhxHO2PcZrOuy_e90hWUCwgp5pzQm00Kk01_DWdm17LZdWZ2FRqtzFvLRtTY2X7-1k04HEL7Wqt_vvdtBjv6ZGcI-YDpTrSqZRW7WjCsXbwETCZDwBlwCKl-ihli-P87_gFbvZq2</recordid><startdate>19850815</startdate><enddate>19850815</enddate><creator>Edwards, David J.</creator><creator>Ravitch, Joshua</creator><creator>Knopf, Steven</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850815</creationdate><title>Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig</title><author>Edwards, David J. ; Ravitch, Joshua ; Knopf, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-8de0ecfee8bc9e002e4031fa98742af1fefe5bc4b4c0112f1cbbfeb6454740cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>3-Methoxy-4-hydroxyphenylethanol - metabolism</topic><topic>Amines - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catecholamines - metabolism</topic><topic>Debrisoquin - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Guinea Pigs</topic><topic>Isoquinolines - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxyhydroxyphenylglycol - metabolism</topic><topic>Monoamine Oxidase Inhibitors - pharmacology</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vanilmandelic Acid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edwards, David J.</creatorcontrib><creatorcontrib>Ravitch, Joshua</creatorcontrib><creatorcontrib>Knopf, Steven</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edwards, David J.</au><au>Ravitch, Joshua</au><au>Knopf, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1985-08-15</date><risdate>1985</risdate><volume>34</volume><issue>16</issue><spage>2911</spage><epage>2916</epage><pages>2911-2916</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>The effects of debrisoquin, administered daily for 4 days to rats (40
mg
kg
, i.p.) and guinea pigs (4
mg
kg
, i.p.), were determined for urinary excretion of several acidic and neutral amine metabolites, including the norepinephrine metabolites, 3-methoxy-4-hydroxyphenethylene glycol (MHPG) and vanillylmandelic acid (VMA), the dopamine metabolites, 3,4-dihydroxyphenethanol (DHPE), 3-methoxy-4-hydroxyphenethanol (MHPE), and homovanillic acid (HVA), and the octopamine metabolite,
p-hydroxyphenylglycol (pHPG). The excretion of MHPG was reduced to 32% of control in rats and to 46% in guinea pigs, HVA was reduced to 64 and 80% in these two species, respectively, and MHPE was lowered to 59% of control in the rat but was not affected in the guinea pig. DHPE and pHPG were not altered significantly in either species. VMA was a minor metabolite in both species, being less than 6% of MHPG, and its formation was blocked only partially (rat) or not at all (guinea pig) by debrisoquin. The data refute the idea based on previous
in vitro studies that VMA is a major metabolite of norepinephrine in the periphery of the guinea pig as it is in man.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3896245</pmid><doi>10.1016/0006-2952(85)90015-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1985-08, Vol.34 (16), p.2911-2916 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| subjects | 3-Methoxy-4-hydroxyphenylethanol - metabolism Amines - metabolism Animals Biological and medical sciences Catecholamines - metabolism Debrisoquin - pharmacology Dose-Response Relationship, Drug General pharmacology Guinea Pigs Isoquinolines - pharmacology Male Medical sciences Methoxyhydroxyphenylglycol - metabolism Monoamine Oxidase Inhibitors - pharmacology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Inbred Strains Vanilmandelic Acid - metabolism |
| title | Effects of debrisoquin on the excretion of catecholamine and octopamine metabolites in the rat and guinea pig |
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