Contamination of Genetically Engineered CHO-cells by Epizootic Haemorrhagic Disease Virus (EHDV)

The characterization of a contaminating virus which was detected in genetically-engineered Chinese hamster ovary (CHO) cells during the production of biologicals is described in the present paper. Under electron microscopy, the contaminating virus had a morphology resembling that of an orbivirus. Th...

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Veröffentlicht in:	Biologicals 1993-09, Vol.21 (3), p.207-214
Hauptverfasser:	Rabenau, Holger, Ohlinger, Volker, Anderson, John, Selb, Bernhard, Cinatl, Jindrich, Wolf, W., Frost, Jens, Mellor, Peter, Doerr, Hans Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cells Animals Biological and medical sciences Biotechnology Cells, Cultured CHO Cells - microbiology Cricetinae Cytopathogenic Effect, Viral epizootic hemorrhagic disease virus Establishment of new cell lines, improvement of cultural methods, mass cultures Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Genetic Engineering Hemorrhagic Disease Virus, Epizootic - isolation & purification Hemorrhagic Disease Virus, Epizootic - pathogenicity Hemorrhagic Disease Virus, Epizootic - ultrastructure Humans Immunoenzyme Techniques Methods. Procedures. Technologies Microscopy, Electron Neutralization Tests Tumor Cells, Cultured
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