Inhibition of Cytokine-Induced β Cell Apoptosis via Laccase and Its Therapeutic Advantages for Insulin-Dependent Diabetes Mellitus, Type 1 Diabetes

In pancreatic islets, free radical formation produced upon exposure to proinflammatory cytokines mediates β cell destruction, which ultimately leads to type 1 diabetes (T1D). In this study, we examined whether laccase, a family of the blue copper protein, can be successfully used to prevent β cells...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2010/11/01, Vol.33(11), pp.1854-1860
Hauptverfasser:	Joo, Seong Soo, Lee, Do Ik, Hwang, Kwang Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Blood Glucose - metabolism Cytochromes c - metabolism Cytokines - metabolism Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Female free radical Insulin - blood Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - physiology laccase Laccase - pharmacology Laccase - therapeutic use Mice Mice, Inbred NOD non-obese diabetic mouse Oxidative Stress - drug effects Peroxynitrous Acid - metabolism Phytotherapy Polyporales - chemistry Rats type 1 diabetes Up-Regulation β cell
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