ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion

ATP, which has an important proinflam-matory action as danger signal, induces the semimaturation of dendritic cells (DCs) that can be associated with immune tolerance. We identified epidermal growth factor receptor ligands as target genes of ATPγS, a slowly hydrolyzed ATP derivative, by a gene profi...

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Veröffentlicht in:	Blood 2010-10, Vol.116 (17), p.3219-3226
Hauptverfasser:	Bles, Nathalie, Di Pietrantonio, Larissa, Boeynaems, Jean-Marie, Communi, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - immunology Amphiregulin Animals Biological and medical sciences Bone Marrow Cells - cytology Carcinoma, Lewis Lung - genetics Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - pathology Cell Line, Tumor Cell Proliferation Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology EGF Family of Proteins Epidermal Growth Factor - genetics Gene Expression Regulation, Neoplastic Glycoproteins - genetics Glycoproteins - immunology Hematologic and hematopoietic diseases Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - immunology Lipopolysaccharides - immunology Male Medical sciences Mice Mice, Inbred C57BL Monocytes - immunology Myocytes, Smooth Muscle - cytology Up-Regulation
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