Association between cholesterolosis and gallbladder cancer
Cholesterolosis is frequently observed in cholecystectomies performed for lithiasis or chronic cholecystitis. To determine the degree of association between cholesterolosis and gallbladder cancer. In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were p...
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| Veröffentlicht in: | Revista medíca de Chile 2010-07, Vol.138 (7), p.804-808 |
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| creator | Roa, Iván de Aretxabala, Xabier Ibacache, Gilda Muñoz, Sergio |
| description | Cholesterolosis is frequently observed in cholecystectomies performed for lithiasis or chronic cholecystitis.
To determine the degree of association between cholesterolosis and gallbladder cancer.
In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol. As part of this study, 23,304 surgical samples obtained between 1993 and 2002 were studied, looking for a relationship between cholesterolosis and chronic cholecystitis, adenomas, dysplasia and gallbladder cancer.
Seventy nine percent of patients were women. Cholesterolosis was observed in 3123 cases (13.4%). Cholesterolosis was more common in women (14.2%) than in men (10.2%9) (p < 0.001). In the same period, 29 patients were diagnosed with adenomas (0.12%), 179 cases with dysplasia not associated with gallbladder cancer (0.8%) and 739 gallbladder cancer (3.2%). The frequency of cholesterolosis was 13.8% in chronic cholecystitis, 13.7% in adenomas, 12.1% in dysplasias and 1.35% in patients with gallbladder cancer (p < 0.01). Of the thirteen cases with gallbladder cancer and cholesterolosis, 10 were early gallbladder carcinomas. Patients with cholesterolosis were 9.2 times less likely td have cancer than those who did not have cholesterolosis.
Cholesterolosis has a strong negative association with gallbladder cancer. |
| format | Article |
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To determine the degree of association between cholesterolosis and gallbladder cancer.
In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol. As part of this study, 23,304 surgical samples obtained between 1993 and 2002 were studied, looking for a relationship between cholesterolosis and chronic cholecystitis, adenomas, dysplasia and gallbladder cancer.
Seventy nine percent of patients were women. Cholesterolosis was observed in 3123 cases (13.4%). Cholesterolosis was more common in women (14.2%) than in men (10.2%9) (p < 0.001). In the same period, 29 patients were diagnosed with adenomas (0.12%), 179 cases with dysplasia not associated with gallbladder cancer (0.8%) and 739 gallbladder cancer (3.2%). The frequency of cholesterolosis was 13.8% in chronic cholecystitis, 13.7% in adenomas, 12.1% in dysplasias and 1.35% in patients with gallbladder cancer (p < 0.01). Of the thirteen cases with gallbladder cancer and cholesterolosis, 10 were early gallbladder carcinomas. Patients with cholesterolosis were 9.2 times less likely td have cancer than those who did not have cholesterolosis.
Cholesterolosis has a strong negative association with gallbladder cancer.</description><identifier>ISSN: 0034-9887</identifier><identifier>PMID: 21043073</identifier><language>spa</language><publisher>Chile</publisher><subject>Adenoma - epidemiology ; Cholelithiasis - epidemiology ; Cholelithiasis - pathology ; Cholelithiasis - surgery ; Epidemiologic Methods ; Female ; Gallbladder Neoplasms - epidemiology ; Humans ; Male ; Middle Aged ; Sex Distribution</subject><ispartof>Revista medíca de Chile, 2010-07, Vol.138 (7), p.804-808</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21043073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roa, Iván</creatorcontrib><creatorcontrib>de Aretxabala, Xabier</creatorcontrib><creatorcontrib>Ibacache, Gilda</creatorcontrib><creatorcontrib>Muñoz, Sergio</creatorcontrib><title>Association between cholesterolosis and gallbladder cancer</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Cholesterolosis is frequently observed in cholecystectomies performed for lithiasis or chronic cholecystitis.
To determine the degree of association between cholesterolosis and gallbladder cancer.
In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol. As part of this study, 23,304 surgical samples obtained between 1993 and 2002 were studied, looking for a relationship between cholesterolosis and chronic cholecystitis, adenomas, dysplasia and gallbladder cancer.
Seventy nine percent of patients were women. Cholesterolosis was observed in 3123 cases (13.4%). Cholesterolosis was more common in women (14.2%) than in men (10.2%9) (p < 0.001). In the same period, 29 patients were diagnosed with adenomas (0.12%), 179 cases with dysplasia not associated with gallbladder cancer (0.8%) and 739 gallbladder cancer (3.2%). The frequency of cholesterolosis was 13.8% in chronic cholecystitis, 13.7% in adenomas, 12.1% in dysplasias and 1.35% in patients with gallbladder cancer (p < 0.01). Of the thirteen cases with gallbladder cancer and cholesterolosis, 10 were early gallbladder carcinomas. Patients with cholesterolosis were 9.2 times less likely td have cancer than those who did not have cholesterolosis.
Cholesterolosis has a strong negative association with gallbladder cancer.</description><subject>Adenoma - epidemiology</subject><subject>Cholelithiasis - epidemiology</subject><subject>Cholelithiasis - pathology</subject><subject>Cholelithiasis - surgery</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Gallbladder Neoplasms - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sex Distribution</subject><issn>0034-9887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jztPwzAURj2AaGn5CygbUyQnvn6xVRUvqRILnaMb-waCnDjYiRD_nkqU6SxHR993wdacCyitMXrFrnP-5LzWqjJXbFVXHATXYs3udzlH1-Pcx7Foaf4mGgv3EQPlmVIMMfe5wNEX7xhCG9B7SoXD0VHasssOQ6abMzfs-Pjwtn8uD69PL_vdoZwq4HNplZStAuukNeCxRqmVxc53RnYVckByiLXRmkBUVqETwoMELpVHpbkSG3b3151S_FpOu5qhz45CwJHikhutatAGuDiZt2dzaQfyzZT6AdNP839X_AIIRU--</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Roa, Iván</creator><creator>de Aretxabala, Xabier</creator><creator>Ibacache, Gilda</creator><creator>Muñoz, Sergio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Association between cholesterolosis and gallbladder cancer</title><author>Roa, Iván ; de Aretxabala, Xabier ; Ibacache, Gilda ; Muñoz, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-9655b649c5984da2a5769afdf85f1a04aecaa2877e43196ac33d454056da67063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2010</creationdate><topic>Adenoma - epidemiology</topic><topic>Cholelithiasis - epidemiology</topic><topic>Cholelithiasis - pathology</topic><topic>Cholelithiasis - surgery</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Gallbladder Neoplasms - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roa, Iván</creatorcontrib><creatorcontrib>de Aretxabala, Xabier</creatorcontrib><creatorcontrib>Ibacache, Gilda</creatorcontrib><creatorcontrib>Muñoz, Sergio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roa, Iván</au><au>de Aretxabala, Xabier</au><au>Ibacache, Gilda</au><au>Muñoz, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between cholesterolosis and gallbladder cancer</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2010-07</date><risdate>2010</risdate><volume>138</volume><issue>7</issue><spage>804</spage><epage>808</epage><pages>804-808</pages><issn>0034-9887</issn><abstract>Cholesterolosis is frequently observed in cholecystectomies performed for lithiasis or chronic cholecystitis.
To determine the degree of association between cholesterolosis and gallbladder cancer.
In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol. As part of this study, 23,304 surgical samples obtained between 1993 and 2002 were studied, looking for a relationship between cholesterolosis and chronic cholecystitis, adenomas, dysplasia and gallbladder cancer.
Seventy nine percent of patients were women. Cholesterolosis was observed in 3123 cases (13.4%). Cholesterolosis was more common in women (14.2%) than in men (10.2%9) (p < 0.001). In the same period, 29 patients were diagnosed with adenomas (0.12%), 179 cases with dysplasia not associated with gallbladder cancer (0.8%) and 739 gallbladder cancer (3.2%). The frequency of cholesterolosis was 13.8% in chronic cholecystitis, 13.7% in adenomas, 12.1% in dysplasias and 1.35% in patients with gallbladder cancer (p < 0.01). Of the thirteen cases with gallbladder cancer and cholesterolosis, 10 were early gallbladder carcinomas. Patients with cholesterolosis were 9.2 times less likely td have cancer than those who did not have cholesterolosis.
Cholesterolosis has a strong negative association with gallbladder cancer.</abstract><cop>Chile</cop><pmid>21043073</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Revista medíca de Chile, 2010-07, Vol.138 (7), p.804-808 |
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| language | spa |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoma - epidemiology Cholelithiasis - epidemiology Cholelithiasis - pathology Cholelithiasis - surgery Epidemiologic Methods Female Gallbladder Neoplasms - epidemiology Humans Male Middle Aged Sex Distribution |
| title | Association between cholesterolosis and gallbladder cancer |
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