Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability, and delivery of gatifloxacin

Dendrimeric polyguanidilyated translocators (DPTs) are nanosized novel dendrimers that efficiently translocate molecules across biological barriers. The purpose of this study was to develop a DPT that could serve as an ophthalmic delivery vehicle for gatifloxacin and to evaluate its in vitro and in...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2010-11, Vol.51 (11), p.5804-5816
Hauptverfasser:	Durairaj, Chandrasekar, Kadam, Rajendra S, Chandler, John W, Hutcherson, Stephen L, Kompella, Uday B
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacokinetics Area Under Curve Calorimetry Cattle Chromatography, High Pressure Liquid Dendrimers - chemistry Drug Delivery Systems Drug Interactions Epithelium, Corneal - metabolism Fluorescein-5-isothiocyanate Fluoroquinolones - administration & dosage Fluoroquinolones - pharmacokinetics Humans Magnetic Resonance Spectroscopy Male Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Microscopy, Confocal Nanoparticles Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - pharmacokinetics Permeability Poly G - chemistry Rabbits Solubility Spectroscopy, Fourier Transform Infrared Tandem Mass Spectrometry Tissue Distribution
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