Conformational Stabilization of Rat S-Adenosylmethionine Decarboxylase by Putrescine

The activity and processing of mammalian S-adenosylmethionine decarboxylase (AdoMetDC) is stimulated by putrescine. To obtain new insights into the mechanism through which putrescine stimulates AdoMetDC, we investigated conformational changes in rat prostate AdoMetDC in the presence or absence of pu...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2010/11/01, Vol.33(11), pp.1800-1805
Hauptverfasser:	Wada, Makiko, Shirahata, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - chemistry Animals conformational stabilization Cysteine - chemistry Iodoacetic Acid - pharmacology Male matrix assisted laser desorption ionization time-of-flight mass spectrometry Methylation Molecular Structure Prostate - metabolism putrescine Putrescine - metabolism Putrescine - pharmacology Rats S-adenosylmethionine decarboxylase SH-reagent Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Trypsin - pharmacology
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