Mechanisms of immune suppression exerted by regulatory T-cells in subcutaneous AE17 murine mesothelioma

We have reported previously that a combined intratumoral treatment with anti-CD25mAb/transforming growth factor-β (TGF-β) soluble receptor induced regression of established and subcutaneous AE17 murine mesotheliomas. Here, we have investigated the mechanisms underlying this observation by analyzing...

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Veröffentlicht in:	Journal of interferon & cytokine research 2010-11, Vol.30 (11), p.829-834
Hauptverfasser:	Kissick, Haydn T, Ireland, Demelza J, Greay, Sara J, Beilharz, Manfred W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibodies, Monoclonal - administration & dosage Care and treatment Cell Line, Tumor Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Female Genetic aspects Health aspects Immune response Immunosuppression Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-2 Receptor alpha Subunit - immunology Lymphocyte Depletion Mesothelioma Mesothelioma - drug therapy Mesothelioma - immunology Mesothelioma - pathology Mice Mice, Inbred C57BL Physiological aspects Prevention Receptors, Transforming Growth Factor beta - administration & dosage Remission Induction Skin Neoplasms - drug therapy Skin Neoplasms - immunology Skin Neoplasms - pathology T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factors Tumor Escape
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