Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC-ESI-MS-MS
A trace analytical procedure was developed to assay the anticancer drugs methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine in water samples from sewage treatment plants. After concentration and purification using Oasis HLB...
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| Veröffentlicht in: | Journal of chromatographic science 2010-11, Vol.48 (10), p.781-789 |
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| container_title | Journal of chromatographic science |
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| creator | Yin, Jie Yang, Yi Li, Keji Zhang, Jing Shao, Bing |
| description | A trace analytical procedure was developed to assay the anticancer drugs methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine in water samples from sewage treatment plants. After concentration and purification using Oasis HLB solid-phase extraction cartridges and Oasis WAX cartridges, the analytes were separated using ultra-high performance liquid chromatography coupled with the electrospray ionization tandem mass spectrometry operating in the positive ion mode. The method showed good precision and accuracy. Recoveries of all analytes were in the range of 45.3–108.9% with relative standard deviations between 2.4–24.5%. The limits of detection for influent and effluent sewage water were in the range of 0.6–7.0 ng/L and 0.5–3.5 ng/L, respectively. It is expected that this method will be applied to investigate the environmental occurrence of anticancer drugs in sewage water. |
| doi_str_mv | 10.1093/chromsci/48.10.781 |
| format | Article |
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After concentration and purification using Oasis HLB solid-phase extraction cartridges and Oasis WAX cartridges, the analytes were separated using ultra-high performance liquid chromatography coupled with the electrospray ionization tandem mass spectrometry operating in the positive ion mode. The method showed good precision and accuracy. Recoveries of all analytes were in the range of 45.3–108.9% with relative standard deviations between 2.4–24.5%. The limits of detection for influent and effluent sewage water were in the range of 0.6–7.0 ng/L and 0.5–3.5 ng/L, respectively. It is expected that this method will be applied to investigate the environmental occurrence of anticancer drugs in sewage water.</description><identifier>ISSN: 0021-9665</identifier><identifier>EISSN: 1945-239X</identifier><identifier>DOI: 10.1093/chromsci/48.10.781</identifier><identifier>PMID: 21044406</identifier><identifier>CODEN: JCHSBZ</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Analytical chemistry ; Antineoplastic Agents - analysis ; Applied sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid - methods ; Exact sciences and technology ; Other chromatographic methods ; Other wastewaters ; Pollution ; Sewage - chemistry ; Solid Phase Extraction - methods ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry - methods ; Wastewaters ; Water Pollutants, Chemical - analysis ; Water treatment and pollution</subject><ispartof>Journal of chromatographic science, 2010-11, Vol.48 (10), p.781-789</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-2718ee6c8eefb20985bcbf5ff0a7cbb011c38ebee91d7346b31271ef91613bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23341958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21044406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Jie</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Li, Keji</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Shao, Bing</creatorcontrib><title>Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC-ESI-MS-MS</title><title>Journal of chromatographic science</title><addtitle>Journal of Chromatographic Science</addtitle><addtitle>Journal of Chromatographic Science</addtitle><description>A trace analytical procedure was developed to assay the anticancer drugs methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine in water samples from sewage treatment plants. After concentration and purification using Oasis HLB solid-phase extraction cartridges and Oasis WAX cartridges, the analytes were separated using ultra-high performance liquid chromatography coupled with the electrospray ionization tandem mass spectrometry operating in the positive ion mode. The method showed good precision and accuracy. Recoveries of all analytes were in the range of 45.3–108.9% with relative standard deviations between 2.4–24.5%. The limits of detection for influent and effluent sewage water were in the range of 0.6–7.0 ng/L and 0.5–3.5 ng/L, respectively. It is expected that this method will be applied to investigate the environmental occurrence of anticancer drugs in sewage water.</description><subject>Analytical chemistry</subject><subject>Antineoplastic Agents - analysis</subject><subject>Applied sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Exact sciences and technology</subject><subject>Other chromatographic methods</subject><subject>Other wastewaters</subject><subject>Pollution</subject><subject>Sewage - chemistry</subject><subject>Solid Phase Extraction - methods</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Wastewaters</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water treatment and pollution</subject><issn>0021-9665</issn><issn>1945-239X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OGzEURi1UVFLaF-ii8qbqasAe2zOeZRrCjxRopASB2Fi2c03dTmaCPQPk7XGUAFsky9b9dL5r6SD0nZIjSip2bP-GdhmtP-YyBUelpHtoQCsuspxVt5_QgJCcZlVRiAP0JcZ_m5FK8Rkd5JRwzkkxQNNho-t19BG3Dg-bzlvdWAj4JPT3EfsGz-BJ3wO-0V1Kf6_TXIPt_CPg2XSMdbPA19PJKBvPLrLLWTpf0b7TdYRvu_cQzU_H89F5NvlzdjEaTjLLieyyvKQSoLDpciYnlRTGGiecI7q0xhBKLZNgACq6KBkvDKOpAq6iBWVmwQ7Rr-3aVWgfeoidWvpooa51A20fVVnkvCSC80TmW9KGNsYATq2CX-qwVpSojUf16lFxucmSx1T6sVvfmyUs3iqv4hLwcwfoaHXtQtLm4zvHGKeVkInLtlzbrz728Y73sYPnt4YO_1VRslKo89s7JeZTcnI1H6lT9gLkspnb</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Yin, Jie</creator><creator>Yang, Yi</creator><creator>Li, Keji</creator><creator>Zhang, Jing</creator><creator>Shao, Bing</creator><general>Oxford University Press</general><general>Preston Publications</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC-ESI-MS-MS</title><author>Yin, Jie ; Yang, Yi ; Li, Keji ; Zhang, Jing ; Shao, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-2718ee6c8eefb20985bcbf5ff0a7cbb011c38ebee91d7346b31271ef91613bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analytical chemistry</topic><topic>Antineoplastic Agents - analysis</topic><topic>Applied sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Exact sciences and technology</topic><topic>Other chromatographic methods</topic><topic>Other wastewaters</topic><topic>Pollution</topic><topic>Sewage - chemistry</topic><topic>Solid Phase Extraction - methods</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Wastewaters</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Jie</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Li, Keji</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Shao, Bing</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatographic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Jie</au><au>Yang, Yi</au><au>Li, Keji</au><au>Zhang, Jing</au><au>Shao, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC-ESI-MS-MS</atitle><jtitle>Journal of chromatographic science</jtitle><stitle>Journal of Chromatographic Science</stitle><addtitle>Journal of Chromatographic Science</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>48</volume><issue>10</issue><spage>781</spage><epage>789</epage><pages>781-789</pages><issn>0021-9665</issn><eissn>1945-239X</eissn><coden>JCHSBZ</coden><abstract>A trace analytical procedure was developed to assay the anticancer drugs methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine in water samples from sewage treatment plants. After concentration and purification using Oasis HLB solid-phase extraction cartridges and Oasis WAX cartridges, the analytes were separated using ultra-high performance liquid chromatography coupled with the electrospray ionization tandem mass spectrometry operating in the positive ion mode. The method showed good precision and accuracy. Recoveries of all analytes were in the range of 45.3–108.9% with relative standard deviations between 2.4–24.5%. The limits of detection for influent and effluent sewage water were in the range of 0.6–7.0 ng/L and 0.5–3.5 ng/L, respectively. It is expected that this method will be applied to investigate the environmental occurrence of anticancer drugs in sewage water.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>21044406</pmid><doi>10.1093/chromsci/48.10.781</doi><tpages>9</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Analytical chemistry Antineoplastic Agents - analysis Applied sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - methods Exact sciences and technology Other chromatographic methods Other wastewaters Pollution Sewage - chemistry Solid Phase Extraction - methods Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Wastewaters Water Pollutants, Chemical - analysis Water treatment and pollution |
| title | Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC-ESI-MS-MS |
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