Impact of second-tier testing on the effectiveness of newborn screening
In one study, MS/MS analysis of newborn spot samples of dried blood collected ≤24 h after birth was compared with fluorometric analysis of the same samples. Because of this early time of collection, the decision level for an increased phenylalanine concentration was lowered by the public health labo...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2010-11, Vol.56 (11), p.1653-1655 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Chace, Donald H Hannon, W Harry |
| description | In one study, MS/MS analysis of newborn spot samples of dried blood collected ≤24 h after birth was compared with fluorometric analysis of the same samples. Because of this early time of collection, the decision level for an increased phenylalanine concentration was lowered by the public health laboratory using fluorometry to ensure that no infants with phenylketonuria were missed. [...] the primary screening of congenital adrenal hyperplasia is done with less selective methods, with a larger capture of presumptive positive cases being followed by a second-tier analysis. |
| doi_str_mv | 10.1373/clinchem.2010.153494 |
| format | Article |
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[...] the primary screening of congenital adrenal hyperplasia is done with less selective methods, with a larger capture of presumptive positive cases being followed by a second-tier analysis.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2010.153494</identifier><identifier>PMID: 20837783</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Algorithms ; Biomarkers ; Biomarkers - blood ; Blood Specimen Collection ; Disease ; False Positive Reactions ; Fluorometry ; Humans ; Infant ; Infant, Newborn ; Laboratories ; Mass spectrometry ; Medical screening ; Metabolic disorders ; Metabolism, Inborn Errors - blood ; Metabolism, Inborn Errors - diagnosis ; Metabolites ; Methods ; Neonatal Screening - methods ; Newborn babies ; Public health ; Reference Values ; Reporting requirements ; Sensitivity and Specificity ; Tandem Mass Spectrometry</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2010-11, Vol.56 (11), p.1653-1655</ispartof><rights>Copyright American Association for Clinical Chemistry Nov 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-75af5e424e7f0b5ae5d3b9b1bffd1a23fd893fc034d9e28b5ba1369355be102b3</citedby><cites>FETCH-LOGICAL-c379t-75af5e424e7f0b5ae5d3b9b1bffd1a23fd893fc034d9e28b5ba1369355be102b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20837783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chace, Donald H</creatorcontrib><creatorcontrib>Hannon, W Harry</creatorcontrib><title>Impact of second-tier testing on the effectiveness of newborn screening</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>In one study, MS/MS analysis of newborn spot samples of dried blood collected ≤24 h after birth was compared with fluorometric analysis of the same samples. 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Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chace, Donald H</au><au>Hannon, W Harry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of second-tier testing on the effectiveness of newborn screening</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2010-11</date><risdate>2010</risdate><volume>56</volume><issue>11</issue><spage>1653</spage><epage>1655</epage><pages>1653-1655</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><abstract>In one study, MS/MS analysis of newborn spot samples of dried blood collected ≤24 h after birth was compared with fluorometric analysis of the same samples. Because of this early time of collection, the decision level for an increased phenylalanine concentration was lowered by the public health laboratory using fluorometry to ensure that no infants with phenylketonuria were missed. [...] the primary screening of congenital adrenal hyperplasia is done with less selective methods, with a larger capture of presumptive positive cases being followed by a second-tier analysis.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>20837783</pmid><doi>10.1373/clinchem.2010.153494</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Algorithms Biomarkers Biomarkers - blood Blood Specimen Collection Disease False Positive Reactions Fluorometry Humans Infant Infant, Newborn Laboratories Mass spectrometry Medical screening Metabolic disorders Metabolism, Inborn Errors - blood Metabolism, Inborn Errors - diagnosis Metabolites Methods Neonatal Screening - methods Newborn babies Public health Reference Values Reporting requirements Sensitivity and Specificity Tandem Mass Spectrometry |
| title | Impact of second-tier testing on the effectiveness of newborn screening |
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