Reduced ACTC1 Expression Might Play a Role in the Onset of Congenital Heart Disease by Inducing Cardiomyocyte Apoptosis

Background: The Cardiac α actin 1 gene (ACTC1) has been related to familial atrial septal defects. This study was set to explore a potential role of this gene in the formation of sporadic congenital heart disease (CHD). Methods and Results: Assessment of cardiac tissue samples from 33 patients with...

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Veröffentlicht in:	Circulation Journal 2010, Vol.74(11), pp.2410-2418
Hauptverfasser:	Jiang, Hong-Kun, Qiu, Guang-Rong, Li-Ling, Jesse, Xin, Na, Sun, Kai-Lai
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Age Factors Animals Apoptosis Bcl-2 Blotting, Western Cardiac α actin 1 Case-Control Studies Caspase 3 - genetics Caspase-3 Cell Line Child, Preschool China Congenital heart disease Down-Regulation Female Gene Expression Regulation, Developmental Gestational Age Heart Defects, Congenital - genetics Heart Defects, Congenital - metabolism Heart Defects, Congenital - pathology Humans Immunohistochemistry In Situ Nick-End Labeling Infant Infant, Newborn Male Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Proto-Oncogene Proteins c-bcl-2 - genetics Rats Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism Transfection
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