Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study
Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular dise...
Gespeichert in:
| Veröffentlicht in: | Journal of thrombosis and haemostasis 2010-10, Vol.8 (10), p.2133-2139 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2139 |
|---|---|
| container_issue | 10 |
| container_start_page | 2133 |
| container_title | Journal of thrombosis and haemostasis |
| container_volume | 8 |
| creator | VIK, A. MATHIESEN, E. B. BROX, J. WILSGAARD, T. NJØLSTAD, I. JØRGENSEN, L. HANSEN, J.‐B. |
| description | Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross‐sectional study including 6516 subjects aged 25–85 years who participated in a population‐based health survey. Results: CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high‐density lipoprotein (HDL) cholesterol, C‐reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P |
| doi_str_mv | 10.1111/j.1538-7836.2010.03990.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_762469442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>762469442</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4180-bfdf27ad687fac577d6f332c55f58f7bc7148724327c9acde0c88783a85962c73</originalsourceid><addsrcrecordid>eNqNkEtOwzAQhi0EoqVwBeQdqxbHTmJnwQJVQEGVkKCsLdeZFJc8ip2o7Y47cBn23IST4NDHGm88tr8Z6_8QwgEZBH5dzgdBxESfCxYPKPG3hCUJGawOUHf_cLirE8Y66MS5OSFBElFyjDqUcCZ4TLto-QS5qk1V4inUS4ASO7BNgStXQ7WwVQ0zsKbEqkyxVv5sUmzK2hQKF5AahetXo99KcA63FJ5BCVbleFEtmu3gn49PTwGe2Kpw31_4uW7S9Sk6ylTu4Gy799DL7c1kOOqPH-_uh9fjvg4DQfrTLM0oV2kseKZ0xHkaZ4xRHUVZJDI-1TwIBacho1wnSqdAtBA-vRJRElPNWQ9dbOb6LO8NuFoWxmnIc1VC1TjpJYRxEobUk2JDals5ZyGTC-tj2rUMiGyty7lshcpWrmytyz_rcuVbz7efNFNvZd-40-yBqw2wNDms_z1YPkxGbcV-ATt1lGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>762469442</pqid></control><display><type>article</type><title>Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>VIK, A. ; MATHIESEN, E. B. ; BROX, J. ; WILSGAARD, T. ; NJØLSTAD, I. ; JØRGENSEN, L. ; HANSEN, J.‐B.</creator><creatorcontrib>VIK, A. ; MATHIESEN, E. B. ; BROX, J. ; WILSGAARD, T. ; NJØLSTAD, I. ; JØRGENSEN, L. ; HANSEN, J.‐B.</creatorcontrib><description>Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross‐sectional study including 6516 subjects aged 25–85 years who participated in a population‐based health survey. Results: CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high‐density lipoprotein (HDL) cholesterol, C‐reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P < 0.0001). There was a significant interaction between age and OPG (P = 0.026). The risk of being in the uppermost quartile of CIMT was reduced (OR 0.52, 95% CI 0.30–0.88) with each standard deviation (SD) higher level of OPG in subjects < 45 years (n = 444), whereas subjects ≥ 55 years of age (n = 4884) had an increased risk of being in the uppermost quartile of CIMT (OR 1.19, 95% CI 1.10–1.29) after adjustment for traditional CVD risk factors. Conclusions: Age has a differential impact on the association between OPG and CIMT in a general population. The present findings may suggest that increased serum OPG does not promote early atherosclerosis in younger subjects.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/j.1538-7836.2010.03990.x</identifier><identifier>PMID: 20738762</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; atherosclerosis ; Atherosclerosis - pathology ; Atherosclerosis - prevention & control ; Blood Pressure ; Body Mass Index ; C-Reactive Protein - biosynthesis ; Cardiovascular Diseases - blood ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Diabetes Mellitus - blood ; Female ; general population ; Humans ; intima media thickness ; Male ; Middle Aged ; Norway ; osteoprotegerin ; Osteoprotegerin - blood ; Risk Factors ; Tunica Intima - pathology ; Tunica Media - pathology</subject><ispartof>Journal of thrombosis and haemostasis, 2010-10, Vol.8 (10), p.2133-2139</ispartof><rights>2010 International Society on Thrombosis and Haemostasis</rights><rights>2010 International Society on Thrombosis and Haemostasis.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4180-bfdf27ad687fac577d6f332c55f58f7bc7148724327c9acde0c88783a85962c73</citedby><cites>FETCH-LOGICAL-c4180-bfdf27ad687fac577d6f332c55f58f7bc7148724327c9acde0c88783a85962c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20738762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIK, A.</creatorcontrib><creatorcontrib>MATHIESEN, E. B.</creatorcontrib><creatorcontrib>BROX, J.</creatorcontrib><creatorcontrib>WILSGAARD, T.</creatorcontrib><creatorcontrib>NJØLSTAD, I.</creatorcontrib><creatorcontrib>JØRGENSEN, L.</creatorcontrib><creatorcontrib>HANSEN, J.‐B.</creatorcontrib><title>Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross‐sectional study including 6516 subjects aged 25–85 years who participated in a population‐based health survey. Results: CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high‐density lipoprotein (HDL) cholesterol, C‐reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P < 0.0001). There was a significant interaction between age and OPG (P = 0.026). The risk of being in the uppermost quartile of CIMT was reduced (OR 0.52, 95% CI 0.30–0.88) with each standard deviation (SD) higher level of OPG in subjects < 45 years (n = 444), whereas subjects ≥ 55 years of age (n = 4884) had an increased risk of being in the uppermost quartile of CIMT (OR 1.19, 95% CI 1.10–1.29) after adjustment for traditional CVD risk factors. Conclusions: Age has a differential impact on the association between OPG and CIMT in a general population. The present findings may suggest that increased serum OPG does not promote early atherosclerosis in younger subjects.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>atherosclerosis</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - prevention & control</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - biosynthesis</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - blood</subject><subject>Female</subject><subject>general population</subject><subject>Humans</subject><subject>intima media thickness</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Norway</subject><subject>osteoprotegerin</subject><subject>Osteoprotegerin - blood</subject><subject>Risk Factors</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQhi0EoqVwBeQdqxbHTmJnwQJVQEGVkKCsLdeZFJc8ip2o7Y47cBn23IST4NDHGm88tr8Z6_8QwgEZBH5dzgdBxESfCxYPKPG3hCUJGawOUHf_cLirE8Y66MS5OSFBElFyjDqUcCZ4TLto-QS5qk1V4inUS4ASO7BNgStXQ7WwVQ0zsKbEqkyxVv5sUmzK2hQKF5AahetXo99KcA63FJ5BCVbleFEtmu3gn49PTwGe2Kpw31_4uW7S9Sk6ylTu4Gy799DL7c1kOOqPH-_uh9fjvg4DQfrTLM0oV2kseKZ0xHkaZ4xRHUVZJDI-1TwIBacho1wnSqdAtBA-vRJRElPNWQ9dbOb6LO8NuFoWxmnIc1VC1TjpJYRxEobUk2JDals5ZyGTC-tj2rUMiGyty7lshcpWrmytyz_rcuVbz7efNFNvZd-40-yBqw2wNDms_z1YPkxGbcV-ATt1lGA</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>VIK, A.</creator><creator>MATHIESEN, E. B.</creator><creator>BROX, J.</creator><creator>WILSGAARD, T.</creator><creator>NJØLSTAD, I.</creator><creator>JØRGENSEN, L.</creator><creator>HANSEN, J.‐B.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study</title><author>VIK, A. ; MATHIESEN, E. B. ; BROX, J. ; WILSGAARD, T. ; NJØLSTAD, I. ; JØRGENSEN, L. ; HANSEN, J.‐B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4180-bfdf27ad687fac577d6f332c55f58f7bc7148724327c9acde0c88783a85962c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>atherosclerosis</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - prevention & control</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - biosynthesis</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - blood</topic><topic>Female</topic><topic>general population</topic><topic>Humans</topic><topic>intima media thickness</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Norway</topic><topic>osteoprotegerin</topic><topic>Osteoprotegerin - blood</topic><topic>Risk Factors</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIK, A.</creatorcontrib><creatorcontrib>MATHIESEN, E. B.</creatorcontrib><creatorcontrib>BROX, J.</creatorcontrib><creatorcontrib>WILSGAARD, T.</creatorcontrib><creatorcontrib>NJØLSTAD, I.</creatorcontrib><creatorcontrib>JØRGENSEN, L.</creatorcontrib><creatorcontrib>HANSEN, J.‐B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIK, A.</au><au>MATHIESEN, E. B.</au><au>BROX, J.</au><au>WILSGAARD, T.</au><au>NJØLSTAD, I.</au><au>JØRGENSEN, L.</au><au>HANSEN, J.‐B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2010-10</date><risdate>2010</risdate><volume>8</volume><issue>10</issue><spage>2133</spage><epage>2139</epage><pages>2133-2139</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross‐sectional study including 6516 subjects aged 25–85 years who participated in a population‐based health survey. Results: CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high‐density lipoprotein (HDL) cholesterol, C‐reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P < 0.0001). There was a significant interaction between age and OPG (P = 0.026). The risk of being in the uppermost quartile of CIMT was reduced (OR 0.52, 95% CI 0.30–0.88) with each standard deviation (SD) higher level of OPG in subjects < 45 years (n = 444), whereas subjects ≥ 55 years of age (n = 4884) had an increased risk of being in the uppermost quartile of CIMT (OR 1.19, 95% CI 1.10–1.29) after adjustment for traditional CVD risk factors. Conclusions: Age has a differential impact on the association between OPG and CIMT in a general population. The present findings may suggest that increased serum OPG does not promote early atherosclerosis in younger subjects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20738762</pmid><doi>10.1111/j.1538-7836.2010.03990.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-7933 |
| ispartof | Journal of thrombosis and haemostasis, 2010-10, Vol.8 (10), p.2133-2139 |
| issn | 1538-7933 1538-7836 1538-7836 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_762469442 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over atherosclerosis Atherosclerosis - pathology Atherosclerosis - prevention & control Blood Pressure Body Mass Index C-Reactive Protein - biosynthesis Cardiovascular Diseases - blood Cholesterol, HDL - blood Cross-Sectional Studies Diabetes Mellitus - blood Female general population Humans intima media thickness Male Middle Aged Norway osteoprotegerin Osteoprotegerin - blood Risk Factors Tunica Intima - pathology Tunica Media - pathology |
| title | Relation between serum osteoprotegerin and carotid intima media thickness in a general population – the Tromsø Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T13%3A05%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relation%20between%20serum%20osteoprotegerin%20and%20carotid%20intima%20media%20thickness%20in%20a%20general%20population%20%E2%80%93%20the%20Troms%C3%B8%20Study&rft.jtitle=Journal%20of%20thrombosis%20and%20haemostasis&rft.au=VIK,%20A.&rft.date=2010-10&rft.volume=8&rft.issue=10&rft.spage=2133&rft.epage=2139&rft.pages=2133-2139&rft.issn=1538-7933&rft.eissn=1538-7836&rft_id=info:doi/10.1111/j.1538-7836.2010.03990.x&rft_dat=%3Cproquest_cross%3E762469442%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=762469442&rft_id=info:pmid/20738762&rfr_iscdi=true |