A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway

Previous work has pointed to a role for the Wnt canonical pathway in fibrosis formation in aged skeletal muscles. In the present study, we studied the dystrophic mdx mouse, which displays skeletal muscle fibrosis. Our results indicated that the muscle resident stromal cell (mrSC) population in the m...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2010-11, Vol.299 (5), p.C939-C947
Hauptverfasser:	Trensz, Frédéric, Haroun, Sonia, Cloutier, Alexandre, Richter, Martin V, Grenier, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - metabolism Cell culture Cell Proliferation Cells Collagen - genetics Collagen - metabolism Cystic fibrosis Fibrosis - metabolism Fibrosis - pathology Hindlimb - anatomy & histology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Musculoskeletal system Proteins Rodents Signal Transduction - physiology Stem Cells - cytology Stem Cells - physiology Stromal Cells - cytology Stromal Cells - physiology Wnt Proteins - genetics Wnt Proteins - metabolism Wnt3 Protein Wnt3A Protein
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