Metabolism of [ 3H]leupeptin by rat liver

Tritium-labeled leupeptin was used to study how this tripeptide proteinase inhibitor interacts with the liver, including the mechanism of its transport into the cell, its subcellular distribution after uptake, and its metabolism once in the tissue. Experiments were done in situ and in a perfused liv...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1985-08, Vol.240 (2), p.768-776
Hauptverfasser:	Dennis, Patricia A., Aronson, Nathan N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Binding, Competitive Biological Transport, Active Chloroquine - pharmacology Exact sciences and technology Leupeptins - metabolism Liver - drug effects Liver - metabolism Lysosomes - metabolism Male Oligopeptides - metabolism Other techniques and industries Perfusion Rats Rats, Inbred Strains Temperature
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