Implementation of a Radioreceptor Assay for Dexmedetomidine

: We have implemented a radioreceptor assay for dexmedetomidine, a novel α2‐adrenoceptor agonist. Receptor‐bearing membranes were prepared from rat cerebral cortex and 3H‐clonidine, 4 nM, was used as the labeled ligand. Dexmedetomidine displaced 3H‐clonidine in a linear fashion over a concentration...

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Veröffentlicht in:	Pharmacology & toxicology 1993-11, Vol.73 (5), p.254-256
Hauptverfasser:	Salonen, Markku, Maze, Mervyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - analysis Adrenergic alpha-Agonists - metabolism Analysis Animals Biological and medical sciences Cerebral Cortex - metabolism Clonidine - metabolism General pharmacology Imidazoles - analysis Imidazoles - metabolism Male Medetomidine Medical sciences Pharmacology. Drug treatments Rabbits Radioligand Assay - methods Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha - metabolism
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