Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide

The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-08, Vol.229 (4716), p.879-881
Hauptverfasser:	Kawatani, Masahito, Rutigliano, Michael, de Groat, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Atropine Autonomic ganglia Biological and medical sciences Cats Cholinergic receptors Cholinergics Depolarization Dosage Electric Stimulation Fundamental and applied biological sciences. Psychology Ganglia Ganglia, Autonomic Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - physiology In Vitro Techniques Membrane Potentials - drug effects Methacholine Chloride Methacholine Compounds - pharmacology Nerves Neurons Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Receptors, Muscarinic - drug effects Receptors, Muscarinic - physiology Receptors, Nicotinic - drug effects Receptors, Nicotinic - physiology Superior cervical ganglion Synaptic transmission Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs
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