Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide
The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 1985-08, Vol.229 (4716), p.879-881 |
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description | The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat. |
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At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3895438</identifier><identifier>PMID: 3895438</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acetylcholine - pharmacology ; Animals ; Atropine ; Autonomic ganglia ; Biological and medical sciences ; Cats ; Cholinergic receptors ; Cholinergics ; Depolarization ; Dosage ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Ganglia ; Ganglia, Autonomic ; Ganglia, Sympathetic - drug effects ; Ganglia, Sympathetic - physiology ; In Vitro Techniques ; Membrane Potentials - drug effects ; Methacholine Chloride ; Methacholine Compounds - pharmacology ; Nerves ; Neurons ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Receptors, Muscarinic - drug effects ; Receptors, Muscarinic - physiology ; Receptors, Nicotinic - drug effects ; Receptors, Nicotinic - physiology ; Superior cervical ganglion ; Synaptic transmission ; Vasoactive Intestinal Peptide - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1985-08, Vol.229 (4716), p.879-881</ispartof><rights>Copyright 1985 The American Association for the Advancement of Science</rights><rights>1985 INIST-CNRS</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</citedby><cites>FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1695296$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1695296$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9273962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3895438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawatani, Masahito</creatorcontrib><creatorcontrib>Rutigliano, Michael</creatorcontrib><creatorcontrib>de Groat, William C.</creatorcontrib><title>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Atropine</subject><subject>Autonomic ganglia</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Cholinergic receptors</subject><subject>Cholinergics</subject><subject>Depolarization</subject><subject>Dosage</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>Ganglia, Autonomic</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Ganglia, Sympathetic - physiology</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials - drug effects</subject><subject>Methacholine Chloride</subject><subject>Methacholine Compounds - pharmacology</subject><subject>Nerves</subject><subject>Neurons</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Receptors, Muscarinic - physiology</subject><subject>Receptors, Nicotinic - drug effects</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Superior cervical ganglion</subject><subject>Synaptic transmission</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9v0zAUB_AIgUYZnLmAlAOCw8jmH40TH0cZpVKhSINdI8d5KZ4cO9gOWvnr8ZRoG1IlKh8sve_HP6T3kuQlRqcYE3bmpQIj4ZSWPJ_T8lEyw4jnGSeIPk5mCFGWlajInybPvL9GKGacHiVHE58l9iP0Vgun_oigrEmFadIvg5exYpRML26kCmOyMs0goUlVROnlrutF-AkhmqUwW30r6l16JbwVMqjfEH0AH5QROv1m9a6HPqgGnidPWqE9vJj24-THp4vvi8_ZerNcLc7XmSwQC1mDiOQt4dBAQ3IoaxBF0baEljWnLecF4gUTqCkwrVGNsEQIasxbKWpGc8bocfJ2vLd39tcQP1J1ykvQWhiwg68KRuaoJMV_IZ4TPEeYRngywq3QUCnT2uCE3IIBJ7Q10KpYPqccI5bjqN_v0XE10Cm5h7_7h0cR4CZsxeB9tbr8eqjcXB0qPywPlOVy_VCe7JPSag1bqGILF5uH-mzU0lnvHbRV71Qn3K7CqLod32oa32qax3ji9dSNoe6gufP3-ZspF3FGdeuEkcrfMR4byhmJ7NXIrn2w7v5VxnPCGf0Lx4oAYA</recordid><startdate>19850830</startdate><enddate>19850830</enddate><creator>Kawatani, Masahito</creator><creator>Rutigliano, Michael</creator><creator>de Groat, William C.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19850830</creationdate><title>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</title><author>Kawatani, Masahito ; Rutigliano, Michael ; de Groat, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Atropine</topic><topic>Autonomic ganglia</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Cholinergic receptors</topic><topic>Cholinergics</topic><topic>Depolarization</topic><topic>Dosage</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>Ganglia, Autonomic</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Ganglia, Sympathetic - physiology</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials - drug effects</topic><topic>Methacholine Chloride</topic><topic>Methacholine Compounds - pharmacology</topic><topic>Nerves</topic><topic>Neurons</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Receptors, Muscarinic - physiology</topic><topic>Receptors, Nicotinic - drug effects</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Superior cervical ganglion</topic><topic>Synaptic transmission</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawatani, Masahito</creatorcontrib><creatorcontrib>Rutigliano, Michael</creatorcontrib><creatorcontrib>de Groat, William C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawatani, Masahito</au><au>Rutigliano, Michael</au><au>de Groat, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1985-08-30</date><risdate>1985</risdate><volume>229</volume><issue>4716</issue><spage>879</spage><epage>881</epage><pages>879-881</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3895438</pmid><doi>10.1126/science.3895438</doi><tpages>3</tpages></addata></record> |
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subjects | Acetylcholine - pharmacology Animals Atropine Autonomic ganglia Biological and medical sciences Cats Cholinergic receptors Cholinergics Depolarization Dosage Electric Stimulation Fundamental and applied biological sciences. Psychology Ganglia Ganglia, Autonomic Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - physiology In Vitro Techniques Membrane Potentials - drug effects Methacholine Chloride Methacholine Compounds - pharmacology Nerves Neurons Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Receptors, Muscarinic - drug effects Receptors, Muscarinic - physiology Receptors, Nicotinic - drug effects Receptors, Nicotinic - physiology Superior cervical ganglion Synaptic transmission Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs |
title | Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide |
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