Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide

The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1985-08, Vol.229 (4716), p.879-881
Hauptverfasser: Kawatani, Masahito, Rutigliano, Michael, de Groat, William C.
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Rutigliano, Michael
de Groat, William C.
description The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.
doi_str_mv 10.1126/science.3895438
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At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3895438</identifier><identifier>PMID: 3895438</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acetylcholine - pharmacology ; Animals ; Atropine ; Autonomic ganglia ; Biological and medical sciences ; Cats ; Cholinergic receptors ; Cholinergics ; Depolarization ; Dosage ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Ganglia ; Ganglia, Autonomic ; Ganglia, Sympathetic - drug effects ; Ganglia, Sympathetic - physiology ; In Vitro Techniques ; Membrane Potentials - drug effects ; Methacholine Chloride ; Methacholine Compounds - pharmacology ; Nerves ; Neurons ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Receptors, Muscarinic - drug effects ; Receptors, Muscarinic - physiology ; Receptors, Nicotinic - drug effects ; Receptors, Nicotinic - physiology ; Superior cervical ganglion ; Synaptic transmission ; Vasoactive Intestinal Peptide - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1985-08, Vol.229 (4716), p.879-881</ispartof><rights>Copyright 1985 The American Association for the Advancement of Science</rights><rights>1985 INIST-CNRS</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</citedby><cites>FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1695296$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1695296$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=9273962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3895438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawatani, Masahito</creatorcontrib><creatorcontrib>Rutigliano, Michael</creatorcontrib><creatorcontrib>de Groat, William C.</creatorcontrib><title>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. 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It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Atropine</subject><subject>Autonomic ganglia</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Cholinergic receptors</subject><subject>Cholinergics</subject><subject>Depolarization</subject><subject>Dosage</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia</subject><subject>Ganglia, Autonomic</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Ganglia, Sympathetic - physiology</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials - drug effects</subject><subject>Methacholine Chloride</subject><subject>Methacholine Compounds - pharmacology</subject><subject>Nerves</subject><subject>Neurons</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Receptors, Muscarinic - physiology</subject><subject>Receptors, Nicotinic - drug effects</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Superior cervical ganglion</subject><subject>Synaptic transmission</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9v0zAUB_AIgUYZnLmAlAOCw8jmH40TH0cZpVKhSINdI8d5KZ4cO9gOWvnr8ZRoG1IlKh8sve_HP6T3kuQlRqcYE3bmpQIj4ZSWPJ_T8lEyw4jnGSeIPk5mCFGWlajInybPvL9GKGacHiVHE58l9iP0Vgun_oigrEmFadIvg5exYpRML26kCmOyMs0goUlVROnlrutF-AkhmqUwW30r6l16JbwVMqjfEH0AH5QROv1m9a6HPqgGnidPWqE9vJj24-THp4vvi8_ZerNcLc7XmSwQC1mDiOQt4dBAQ3IoaxBF0baEljWnLecF4gUTqCkwrVGNsEQIasxbKWpGc8bocfJ2vLd39tcQP1J1ykvQWhiwg68KRuaoJMV_IZ4TPEeYRngywq3QUCnT2uCE3IIBJ7Q10KpYPqccI5bjqN_v0XE10Cm5h7_7h0cR4CZsxeB9tbr8eqjcXB0qPywPlOVy_VCe7JPSag1bqGILF5uH-mzU0lnvHbRV71Qn3K7CqLod32oa32qax3ji9dSNoe6gufP3-ZspF3FGdeuEkcrfMR4byhmJ7NXIrn2w7v5VxnPCGf0Lx4oAYA</recordid><startdate>19850830</startdate><enddate>19850830</enddate><creator>Kawatani, Masahito</creator><creator>Rutigliano, Michael</creator><creator>de Groat, William C.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19850830</creationdate><title>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</title><author>Kawatani, Masahito ; Rutigliano, Michael ; de Groat, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c706t-d02c9f29eded25e8bea77ff238b93f9970976a0d713b0b01c00eb19fcab635663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Atropine</topic><topic>Autonomic ganglia</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Cholinergic receptors</topic><topic>Cholinergics</topic><topic>Depolarization</topic><topic>Dosage</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>Ganglia, Autonomic</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Ganglia, Sympathetic - physiology</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials - drug effects</topic><topic>Methacholine Chloride</topic><topic>Methacholine Compounds - pharmacology</topic><topic>Nerves</topic><topic>Neurons</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Receptors, Muscarinic - physiology</topic><topic>Receptors, Nicotinic - drug effects</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Superior cervical ganglion</topic><topic>Synaptic transmission</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawatani, Masahito</creatorcontrib><creatorcontrib>Rutigliano, Michael</creatorcontrib><creatorcontrib>de Groat, William C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawatani, Masahito</au><au>Rutigliano, Michael</au><au>de Groat, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1985-08-30</date><risdate>1985</risdate><volume>229</volume><issue>4716</issue><spage>879</spage><epage>881</epage><pages>879-881</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-β-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the postganglionic discharge elicited by acetyl-β-methylcholine, enhanced muscarinic transmission in ganglia treated with an anticholinesterase agent, and enhanced the late muscarinic discharge elicited by acetylcholine. VIP did not affect the early nicotinic discharge elicited by acetylcholine or by electrical stimulation of the preganglionic nerve. It is concluded that VIP has a selective facilitatory action on muscarinic excitatory mechanisms in the superior cervical ganglion of the cat.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3895438</pmid><doi>10.1126/science.3895438</doi><tpages>3</tpages></addata></record>
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subjects Acetylcholine - pharmacology
Animals
Atropine
Autonomic ganglia
Biological and medical sciences
Cats
Cholinergic receptors
Cholinergics
Depolarization
Dosage
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Ganglia
Ganglia, Autonomic
Ganglia, Sympathetic - drug effects
Ganglia, Sympathetic - physiology
In Vitro Techniques
Membrane Potentials - drug effects
Methacholine Chloride
Methacholine Compounds - pharmacology
Nerves
Neurons
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Receptors, Muscarinic - drug effects
Receptors, Muscarinic - physiology
Receptors, Nicotinic - drug effects
Receptors, Nicotinic - physiology
Superior cervical ganglion
Synaptic transmission
Vasoactive Intestinal Peptide - pharmacology
Vertebrates: nervous system and sense organs
title Depolarization and Muscarinic Excitation Induced in a Sympathetic Ganglion by Vasoactive Intestinal Polypeptide
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