The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: In vivo and in vitro dose and time dependency of metabolism

This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEH...

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Veröffentlicht in:	Toxicol. Appl. Pharmacol.; (United States) 1985-08, Vol.80 (1), p.11-22
Hauptverfasser:	Lhuguenot, Jean-Claude, Mitchell, Angela M., Milner, Gary, Lock, Edward A., Elcombe, Clifford R.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MATERIALS BIOLOGICAL WASTES Biotransformation BODY BODY FLUIDS CARBON 14 COMPOUNDS Carbon Radioisotopes CARBOXYLIC ACID SALTS Chemical and industrial products toxicology. Toxic occupational diseases Diethylhexyl Phthalate - administration & dosage Diethylhexyl Phthalate - analogs & derivatives Diethylhexyl Phthalate - metabolism DIGESTIVE SYSTEM Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS GLANDS IN VITRO In Vitro Techniques ISOTOPE APPLICATIONS LABELLED COMPOUNDS LIVER Liver - metabolism Male MAMMALS MATERIALS Medical sciences METABOLISM METABOLITES Microbodies - metabolism ORAL ADMINISTRATION ORGANS Oxidation-Reduction Palmitoyl Coenzyme A - metabolism PHTHALATES Phthalic Acids - metabolism RATS Rats, Inbred Strains RODENTS TIME DEPENDENCE Time Factors Toxicology TRACER TECHNIQUES URINE Various organic compounds VERTEBRATES WASTES
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