Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box
The tachykinin NK2 receptor antagonists, GR100679 (0.02-200 micrograms/kg s.c.) and (+/-)-SR489698 (0.05-5.0 micrograms/kg s.c.), dose-dependently increased the time which mice spent in the light side of the light-dark box. There was no evidence of sedation or other over behaviours. The amplitudes o...
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| Veröffentlicht in: | European journal of pharmacology 1993-12, Vol.250 (3), p.R11-R12 |
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| container_issue | 3 |
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| container_title | European journal of pharmacology |
| container_volume | 250 |
| creator | STRATTON, S. C BERESFORD, I. J. M HARVEY, F. J TURPIN, M. P HAGAN, R. M TYERS, M. B |
| description | The tachykinin NK2 receptor antagonists, GR100679 (0.02-200 micrograms/kg s.c.) and (+/-)-SR489698 (0.05-5.0 micrograms/kg s.c.), dose-dependently increased the time which mice spent in the light side of the light-dark box. There was no evidence of sedation or other over behaviours. The amplitudes of these effects were similar to that evoked by diazepam (1.75 mg/kg s.c.). These results indicate a disinhibitory action of NK2 antagonists on suppressed behaviours in a novel aversive environment. This suggests an involvement of NK2 receptors in anxiety-related behaviours. |
| doi_str_mv | 10.1016/0014-2999(93)90042-G |
| format | Article |
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This suggests an involvement of NK2 receptors in anxiety-related behaviours.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(93)90042-G</identifier><identifier>PMID: 7906655</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Analysis of Variance ; Animals ; Anti-Anxiety Agents - pharmacology ; Anxiety - etiology ; Behavior, Animal - drug effects ; Benzamides - administration & dosage ; Benzamides - pharmacology ; Biological and medical sciences ; Darkness ; Injections, Subcutaneous ; Light ; Male ; Medical sciences ; Mice ; Neuropharmacology ; Oligopeptides - administration & dosage ; Oligopeptides - pharmacology ; Pharmacology. Drug treatments ; Piperidines - administration & dosage ; Piperidines - pharmacology ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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C</creatorcontrib><creatorcontrib>BERESFORD, I. J. M</creatorcontrib><creatorcontrib>HARVEY, F. J</creatorcontrib><creatorcontrib>TURPIN, M. P</creatorcontrib><creatorcontrib>HAGAN, R. M</creatorcontrib><creatorcontrib>TYERS, M. B</creatorcontrib><title>Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The tachykinin NK2 receptor antagonists, GR100679 (0.02-200 micrograms/kg s.c.) and (+/-)-SR489698 (0.05-5.0 micrograms/kg s.c.), dose-dependently increased the time which mice spent in the light side of the light-dark box. There was no evidence of sedation or other over behaviours. The amplitudes of these effects were similar to that evoked by diazepam (1.75 mg/kg s.c.). These results indicate a disinhibitory action of NK2 antagonists on suppressed behaviours in a novel aversive environment. This suggests an involvement of NK2 receptors in anxiety-related behaviours.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anxiety - etiology</subject><subject>Behavior, Animal - drug effects</subject><subject>Benzamides - administration & dosage</subject><subject>Benzamides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Darkness</subject><subject>Injections, Subcutaneous</subject><subject>Light</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Oligopeptides - administration & dosage</subject><subject>Oligopeptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Receptors, Neurokinin-2 - antagonists & inhibitors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFOAjEQhhujQUTfQJMejNHD6rTdttsjIYpGohf12pTShcqyi20x8PYuQjhNJv_3TyYfQpcE7gkQ8QBA8owqpW4Vu1MAOc2GR6hLCqkykIQeo-4BOUVnMX4DAFeUd1BHKhCC8y766tdr31Sb5C02Nvlfnza4KXEydraZ-9rX-O2V4uCsW6YmYFMnM21qH1PEbZZmDi-aVXS48tNZyiYmzPG4WZ-jk9JU0V3sZw99Pj1-DJ6z0fvwZdAfZZYxkjIKE1LY3BSSl4JJSx0blyJ3UuTWSsFtuyjOi1JJqYyx4MS4ACtzqsQWYD10s7u7DM3PysWkFz5aV1Wmdu1bWgrKKJe0BfMdaEMTY3ClXga_MGGjCeitTr11pbeutGL6X6cetrWr_f3VeOEmh9LeX5tf73MTranKYGrr4wFjBSuAAvsD0Jl9GQ</recordid><startdate>19931221</startdate><enddate>19931221</enddate><creator>STRATTON, S. C</creator><creator>BERESFORD, I. J. M</creator><creator>HARVEY, F. J</creator><creator>TURPIN, M. P</creator><creator>HAGAN, R. 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Drug treatments</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - pharmacology</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Receptors, Neurokinin-2 - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STRATTON, S. C</creatorcontrib><creatorcontrib>BERESFORD, I. J. M</creatorcontrib><creatorcontrib>HARVEY, F. J</creatorcontrib><creatorcontrib>TURPIN, M. P</creatorcontrib><creatorcontrib>HAGAN, R. M</creatorcontrib><creatorcontrib>TYERS, M. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1993-12-21</date><risdate>1993</risdate><volume>250</volume><issue>3</issue><spage>R11</spage><epage>R12</epage><pages>R11-R12</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The tachykinin NK2 receptor antagonists, GR100679 (0.02-200 micrograms/kg s.c.) and (+/-)-SR489698 (0.05-5.0 micrograms/kg s.c.), dose-dependently increased the time which mice spent in the light side of the light-dark box. There was no evidence of sedation or other over behaviours. The amplitudes of these effects were similar to that evoked by diazepam (1.75 mg/kg s.c.). These results indicate a disinhibitory action of NK2 antagonists on suppressed behaviours in a novel aversive environment. This suggests an involvement of NK2 receptors in anxiety-related behaviours.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>7906655</pmid><doi>10.1016/0014-2999(93)90042-G</doi></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis of Variance Animals Anti-Anxiety Agents - pharmacology Anxiety - etiology Behavior, Animal - drug effects Benzamides - administration & dosage Benzamides - pharmacology Biological and medical sciences Darkness Injections, Subcutaneous Light Male Medical sciences Mice Neuropharmacology Oligopeptides - administration & dosage Oligopeptides - pharmacology Pharmacology. Drug treatments Piperidines - administration & dosage Piperidines - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Neurokinin-2 - antagonists & inhibitors |
| title | Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box |
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