Neuronal histamine in the hypothalamus suppresses food intake in rats

Using probes to manipulate hypothalamic neuronal histamine, we report here that changes in neuronal histamine modulate physiological feeding behavior in rats. Infusion of α-fluoromethylhistidine (FMH), a “suicide” inhibitor of histidine decar☐ylase (HDC), into the third cerebroventricular induced fe...

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Veröffentlicht in:	Brain research 1993-11, Vol.628 (1), p.235-242
Hauptverfasser:	Ookuma, Kazuyoshi, Sakata, Toshiie, Fukagawa, Koji, Yoshimatsu, Hironobu, Kurokawa, Mamoru, Machidori, Hironobu, Fujimoto, Kazuma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Catecholamines - metabolism Cerebral Ventricles Eating - physiology Feedback Feeding suppression Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Histamine - metabolism Histamine - physiology Histamine Antagonists Histamine H 3 receptor Histidine Decarboxylase - antagonists & inhibitors Hypothalamus - physiology Infusions, Parenteral Male Methylhistidines - pharmacology Neuronal histamine Neurons - physiology Piperidines - pharmacology Rats Rats, Wistar Thioperamide Vertebrates: anatomy and physiology, studies on body, several organs or systems α-Fluoromethylhistidine
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