Susceptibility of Balb/c, C57/B6 and C57/B10 mice to infection with Mycobacterium paratuberculosis
Balb/C, C57/B10 and G57/B6 mice were examined for their susceptibility to disseminated Mycobacterium parahtherculosis infection after intraperitoneal inoculation with a suspension of organisms containing mineral oil. Animals were examined monthly by histopathology and bacterial tissue counts of live...
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| Veröffentlicht in: | Journal of comparative pathology 1993-11, Vol.109 (4), p.309-319 |
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| creator | Chiodini, R.J. Buergelt, C.D. |
| description | Balb/C, C57/B10 and G57/B6 mice were examined for their susceptibility to disseminated Mycobacterium parahtherculosis infection after intraperitoneal inoculation with a suspension of organisms containing mineral oil. Animals were examined monthly by histopathology and bacterial tissue counts of liver and spleen over a 6-month period. Only Balb/c mice maintained a steady infection with an average of 4.1 x 10
5 ± 7.8 x 10
3 and 8.1 x 10
5 ± 2 .6 x 10
4 colony forming units (cfu) per gram of liver and spleen, respectively, during the course of the study. In contrast, C57/1310 mice reduced the bacterial counts in the liver and spleen from 6.8 x 10
4 and 1.3 x 10
5 to 7.1 x 102 and 4.3 x 1O
3, respectively during the first 120-150 clays after infection. The reduction in cfu was associated with the development of caseous necrotic lesions. C57/B10 mice were of intermediate resistance, slowly reducing cfu in the liver, but not the spleen, during the 6-month period. Balb/c was found to be a suitable mouse strain fiar the study of chronic M. paratuberculosis infection. |
| doi_str_mv | 10.1016/S0021-9975(08)80295-2 |
| format | Article |
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5 ± 7.8 x 10
3 and 8.1 x 10
5 ± 2 .6 x 10
4 colony forming units (cfu) per gram of liver and spleen, respectively, during the course of the study. In contrast, C57/1310 mice reduced the bacterial counts in the liver and spleen from 6.8 x 10
4 and 1.3 x 10
5 to 7.1 x 102 and 4.3 x 1O
3, respectively during the first 120-150 clays after infection. The reduction in cfu was associated with the development of caseous necrotic lesions. C57/B10 mice were of intermediate resistance, slowly reducing cfu in the liver, but not the spleen, during the 6-month period. Balb/c was found to be a suitable mouse strain fiar the study of chronic M. paratuberculosis infection.</description><identifier>ISSN: 0021-9975</identifier><identifier>EISSN: 1532-3129</identifier><identifier>DOI: 10.1016/S0021-9975(08)80295-2</identifier><identifier>PMID: 8106664</identifier><identifier>CODEN: JCVPAR</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Animals ; Bacterial diseases ; Biological and medical sciences ; Colony Count, Microbial ; Disease Susceptibility ; Experimental bacterial diseases and models ; Female ; Granuloma - etiology ; Granuloma - microbiology ; Granuloma - pathology ; Infectious diseases ; Liver - microbiology ; Liver - pathology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Paratuberculosis - complications ; Paratuberculosis - microbiology ; Paratuberculosis - pathology ; Peritoneal Diseases - etiology ; Peritoneal Diseases - microbiology ; Peritoneal Diseases - pathology ; Species Specificity ; Spleen - microbiology ; Spleen - pathology ; Time Factors</subject><ispartof>Journal of comparative pathology, 1993-11, Vol.109 (4), p.309-319</ispartof><rights>1993 Academic Press Limited</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-33d3ebdee1ffebd9a2717e44e442b690f92d1901878d409a22bf157926bee0883</citedby><cites>FETCH-LOGICAL-c389t-33d3ebdee1ffebd9a2717e44e442b690f92d1901878d409a22bf157926bee0883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021997508802952$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3876442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8106664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiodini, R.J.</creatorcontrib><creatorcontrib>Buergelt, C.D.</creatorcontrib><title>Susceptibility of Balb/c, C57/B6 and C57/B10 mice to infection with Mycobacterium paratuberculosis</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>Balb/C, C57/B10 and G57/B6 mice were examined for their susceptibility to disseminated Mycobacterium parahtherculosis infection after intraperitoneal inoculation with a suspension of organisms containing mineral oil. Animals were examined monthly by histopathology and bacterial tissue counts of liver and spleen over a 6-month period. Only Balb/c mice maintained a steady infection with an average of 4.1 x 10
5 ± 7.8 x 10
3 and 8.1 x 10
5 ± 2 .6 x 10
4 colony forming units (cfu) per gram of liver and spleen, respectively, during the course of the study. In contrast, C57/1310 mice reduced the bacterial counts in the liver and spleen from 6.8 x 10
4 and 1.3 x 10
5 to 7.1 x 102 and 4.3 x 1O
3, respectively during the first 120-150 clays after infection. The reduction in cfu was associated with the development of caseous necrotic lesions. C57/B10 mice were of intermediate resistance, slowly reducing cfu in the liver, but not the spleen, during the 6-month period. Balb/c was found to be a suitable mouse strain fiar the study of chronic M. paratuberculosis infection.</description><subject>Animals</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Colony Count, Microbial</subject><subject>Disease Susceptibility</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Granuloma - etiology</subject><subject>Granuloma - microbiology</subject><subject>Granuloma - pathology</subject><subject>Infectious diseases</subject><subject>Liver - microbiology</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Paratuberculosis - complications</subject><subject>Paratuberculosis - microbiology</subject><subject>Paratuberculosis - pathology</subject><subject>Peritoneal Diseases - etiology</subject><subject>Peritoneal Diseases - microbiology</subject><subject>Peritoneal Diseases - pathology</subject><subject>Species Specificity</subject><subject>Spleen - microbiology</subject><subject>Spleen - pathology</subject><subject>Time Factors</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rHCEUhiU0pNu0PyHgRSkpdLp-7Dh6FZIlH4WUXqS9FnWOxDIzbtVp2H8fk132NiAc4TzH4_sgdEbJd0qoWD4QwmijVNeeE_lVEqbahh2hBW05azhl6h1aHJD36EPOfwkhUrbsBJ1ISoQQqwWyD3N2sCnBhiGULY4eX5nBLt03vG675ZXAZup3V0rwGBzgEnGYPLgS4oSfQnnEP7cuWuMKpDCPeGOSKbOF5OYh5pA_omNvhgyf9vUU_bm5_r2-a-5_3f5YX943jktVGs57DrYHoN7XqgzraAerVT3MCkW8Yj1VhMpO9itS28x62naKCQtQc_FT9GX37ibFfzPkosdQsw2DmSDOWXeCccKpqmC7A12KOSfwepPCaNJWU6Jf3OpXt_pFnCZSv7rVrM6d7RfMdoT-MLWXWfuf932TnRl8MpML-YBx2YmapWIXOwyqjP8Bks4uwOSgD6la1X0Mb3zkGaBWlCY</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Chiodini, R.J.</creator><creator>Buergelt, C.D.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931101</creationdate><title>Susceptibility of Balb/c, C57/B6 and C57/B10 mice to infection with Mycobacterium paratuberculosis</title><author>Chiodini, R.J. ; Buergelt, C.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-33d3ebdee1ffebd9a2717e44e442b690f92d1901878d409a22bf157926bee0883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Colony Count, Microbial</topic><topic>Disease Susceptibility</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Granuloma - etiology</topic><topic>Granuloma - microbiology</topic><topic>Granuloma - pathology</topic><topic>Infectious diseases</topic><topic>Liver - microbiology</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Paratuberculosis - complications</topic><topic>Paratuberculosis - microbiology</topic><topic>Paratuberculosis - pathology</topic><topic>Peritoneal Diseases - etiology</topic><topic>Peritoneal Diseases - microbiology</topic><topic>Peritoneal Diseases - pathology</topic><topic>Species Specificity</topic><topic>Spleen - microbiology</topic><topic>Spleen - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiodini, R.J.</creatorcontrib><creatorcontrib>Buergelt, C.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiodini, R.J.</au><au>Buergelt, C.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of Balb/c, C57/B6 and C57/B10 mice to infection with Mycobacterium paratuberculosis</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>109</volume><issue>4</issue><spage>309</spage><epage>319</epage><pages>309-319</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><coden>JCVPAR</coden><abstract>Balb/C, C57/B10 and G57/B6 mice were examined for their susceptibility to disseminated Mycobacterium parahtherculosis infection after intraperitoneal inoculation with a suspension of organisms containing mineral oil. Animals were examined monthly by histopathology and bacterial tissue counts of liver and spleen over a 6-month period. Only Balb/c mice maintained a steady infection with an average of 4.1 x 10
5 ± 7.8 x 10
3 and 8.1 x 10
5 ± 2 .6 x 10
4 colony forming units (cfu) per gram of liver and spleen, respectively, during the course of the study. In contrast, C57/1310 mice reduced the bacterial counts in the liver and spleen from 6.8 x 10
4 and 1.3 x 10
5 to 7.1 x 102 and 4.3 x 1O
3, respectively during the first 120-150 clays after infection. The reduction in cfu was associated with the development of caseous necrotic lesions. C57/B10 mice were of intermediate resistance, slowly reducing cfu in the liver, but not the spleen, during the 6-month period. Balb/c was found to be a suitable mouse strain fiar the study of chronic M. paratuberculosis infection.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8106664</pmid><doi>10.1016/S0021-9975(08)80295-2</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Bacterial diseases Biological and medical sciences Colony Count, Microbial Disease Susceptibility Experimental bacterial diseases and models Female Granuloma - etiology Granuloma - microbiology Granuloma - pathology Infectious diseases Liver - microbiology Liver - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Paratuberculosis - complications Paratuberculosis - microbiology Paratuberculosis - pathology Peritoneal Diseases - etiology Peritoneal Diseases - microbiology Peritoneal Diseases - pathology Species Specificity Spleen - microbiology Spleen - pathology Time Factors |
| title | Susceptibility of Balb/c, C57/B6 and C57/B10 mice to infection with Mycobacterium paratuberculosis |
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