Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy?
Three adolescents with severe CrohnʼS ileocolitis developed osteonecrosis after receiving intravenous corticosteroids and parenteral nutrition, including 10% lipid infusion. Each had achieved clinical remission with therapy. However, several months following completion of therapy, each developed art...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1985-06, Vol.4 (3), p.502-506 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 506 |
|---|---|
| container_issue | 3 |
| container_start_page | 502 |
| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 4 |
| creator | Shapiro, Steven C Rothstein, Fred C Newman, Arthur J Fletcher, Barry Halpin, Thomas C |
| description | Three adolescents with severe CrohnʼS ileocolitis developed osteonecrosis after receiving intravenous corticosteroids and parenteral nutrition, including 10% lipid infusion. Each had achieved clinical remission with therapy. However, several months following completion of therapy, each developed arthralgias and arthritis of weight-bearing and non-weight-bearing joints. Roentgenographic evaluation revealed osteonecrosis involving multiple joints. Osteone crosis may result from the interference with blood flow to bone and has been produced in animals by infusion of lipid solutions and administration of corticosteroids. We report these cases of osteonecrosis as a probable complication of corticosteroid and lipid infusion in adolescents treated for severe CrohnʼS disease. |
| doi_str_mv | 10.1002/j.1536-4801.1985.tb08887.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76230106</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76230106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1781-f1b0fa0748e4c0316fadbeb147b5c0d945dde7c792dd589c9fcd1b6aa60b1f6b3</originalsourceid><addsrcrecordid>eNo9kU2O1DAQhS0EGpqBIyBZCLFLKCfxT2aDWs2vNGgWDAtWluPYiht33NiJeuZunIBT4aijXlgl673nqvqM0BsCJQGo3u9LQmtWNAJISVpBy6kDIQQvH56gzUV6ijZQcV5UhLDn6EVKewDgDYUrdNVABVTUG_Tr--wnZ4NWHt-lyYTR6BiSS9iNeNsHb5I245TwyU0D3sUwjP_-_sAfXTIqmRu8xbtwOHqn1eTCiIPF94OJ6vj44SV6ZpVP5tVar9HPz5_ud1-L27sv33bb20ITLkhhSQdW5bmEaTTUhFnVd6YjDe-ohr5taN8brnlb9T0VrW6t7knHlGLQEcu6-hq9O797jOHPbNIkDy7P7L0aTZiT5KyqgQDLxpuzcVkwRWPlMbqDio-SgFy4yr1c4MkFnly4ypWrfMjh12uXuTuY_hJdQWb97aqrlFnaqEbt0sXWVozymmRbc7adgp9MTL_9fDJRDkb5aZD5f4ASzoqlObB8K_LJsf-snZOL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76230106</pqid></control><display><type>article</type><title>Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy?</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Shapiro, Steven C ; Rothstein, Fred C ; Newman, Arthur J ; Fletcher, Barry ; Halpin, Thomas C</creator><creatorcontrib>Shapiro, Steven C ; Rothstein, Fred C ; Newman, Arthur J ; Fletcher, Barry ; Halpin, Thomas C</creatorcontrib><description>Three adolescents with severe CrohnʼS ileocolitis developed osteonecrosis after receiving intravenous corticosteroids and parenteral nutrition, including 10% lipid infusion. Each had achieved clinical remission with therapy. However, several months following completion of therapy, each developed arthralgias and arthritis of weight-bearing and non-weight-bearing joints. Roentgenographic evaluation revealed osteonecrosis involving multiple joints. Osteone crosis may result from the interference with blood flow to bone and has been produced in animals by infusion of lipid solutions and administration of corticosteroids. We report these cases of osteonecrosis as a probable complication of corticosteroid and lipid infusion in adolescents treated for severe CrohnʼS disease.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1985.tb08887.x</identifier><identifier>PMID: 4020583</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Adrenal Cortex Hormones - adverse effects ; Adrenal Cortex Hormones - therapeutic use ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Crohn Disease - blood ; Crohn Disease - therapy ; Emergency and intensive care: digestive diseases. Bioartificial liver ; Fat Emulsions, Intravenous - adverse effects ; Fat Emulsions, Intravenous - therapeutic use ; Female ; Humans ; Intensive care medicine ; Lipids - blood ; Male ; Medical sciences ; Osteonecrosis - etiology</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1985-06, Vol.4 (3), p.502-506</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9265731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4020583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shapiro, Steven C</creatorcontrib><creatorcontrib>Rothstein, Fred C</creatorcontrib><creatorcontrib>Newman, Arthur J</creatorcontrib><creatorcontrib>Fletcher, Barry</creatorcontrib><creatorcontrib>Halpin, Thomas C</creatorcontrib><title>Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy?</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Three adolescents with severe CrohnʼS ileocolitis developed osteonecrosis after receiving intravenous corticosteroids and parenteral nutrition, including 10% lipid infusion. Each had achieved clinical remission with therapy. However, several months following completion of therapy, each developed arthralgias and arthritis of weight-bearing and non-weight-bearing joints. Roentgenographic evaluation revealed osteonecrosis involving multiple joints. Osteone crosis may result from the interference with blood flow to bone and has been produced in animals by infusion of lipid solutions and administration of corticosteroids. We report these cases of osteonecrosis as a probable complication of corticosteroid and lipid infusion in adolescents treated for severe CrohnʼS disease.</description><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - adverse effects</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - therapy</subject><subject>Emergency and intensive care: digestive diseases. Bioartificial liver</subject><subject>Fat Emulsions, Intravenous - adverse effects</subject><subject>Fat Emulsions, Intravenous - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osteonecrosis - etiology</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU2O1DAQhS0EGpqBIyBZCLFLKCfxT2aDWs2vNGgWDAtWluPYiht33NiJeuZunIBT4aijXlgl673nqvqM0BsCJQGo3u9LQmtWNAJISVpBy6kDIQQvH56gzUV6ijZQcV5UhLDn6EVKewDgDYUrdNVABVTUG_Tr--wnZ4NWHt-lyYTR6BiSS9iNeNsHb5I245TwyU0D3sUwjP_-_sAfXTIqmRu8xbtwOHqn1eTCiIPF94OJ6vj44SV6ZpVP5tVar9HPz5_ud1-L27sv33bb20ITLkhhSQdW5bmEaTTUhFnVd6YjDe-ohr5taN8brnlb9T0VrW6t7knHlGLQEcu6-hq9O797jOHPbNIkDy7P7L0aTZiT5KyqgQDLxpuzcVkwRWPlMbqDio-SgFy4yr1c4MkFnly4ypWrfMjh12uXuTuY_hJdQWb97aqrlFnaqEbt0sXWVozymmRbc7adgp9MTL_9fDJRDkb5aZD5f4ASzoqlObB8K_LJsf-snZOL</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>Shapiro, Steven C</creator><creator>Rothstein, Fred C</creator><creator>Newman, Arthur J</creator><creator>Fletcher, Barry</creator><creator>Halpin, Thomas C</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy?</title><author>Shapiro, Steven C ; Rothstein, Fred C ; Newman, Arthur J ; Fletcher, Barry ; Halpin, Thomas C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1781-f1b0fa0748e4c0316fadbeb147b5c0d945dde7c792dd589c9fcd1b6aa60b1f6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - adverse effects</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - therapy</topic><topic>Emergency and intensive care: digestive diseases. Bioartificial liver</topic><topic>Fat Emulsions, Intravenous - adverse effects</topic><topic>Fat Emulsions, Intravenous - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osteonecrosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapiro, Steven C</creatorcontrib><creatorcontrib>Rothstein, Fred C</creatorcontrib><creatorcontrib>Newman, Arthur J</creatorcontrib><creatorcontrib>Fletcher, Barry</creatorcontrib><creatorcontrib>Halpin, Thomas C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapiro, Steven C</au><au>Rothstein, Fred C</au><au>Newman, Arthur J</au><au>Fletcher, Barry</au><au>Halpin, Thomas C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy?</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1985-06</date><risdate>1985</risdate><volume>4</volume><issue>3</issue><spage>502</spage><epage>506</epage><pages>502-506</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Three adolescents with severe CrohnʼS ileocolitis developed osteonecrosis after receiving intravenous corticosteroids and parenteral nutrition, including 10% lipid infusion. Each had achieved clinical remission with therapy. However, several months following completion of therapy, each developed arthralgias and arthritis of weight-bearing and non-weight-bearing joints. Roentgenographic evaluation revealed osteonecrosis involving multiple joints. Osteone crosis may result from the interference with blood flow to bone and has been produced in animals by infusion of lipid solutions and administration of corticosteroids. We report these cases of osteonecrosis as a probable complication of corticosteroid and lipid infusion in adolescents treated for severe CrohnʼS disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>4020583</pmid><doi>10.1002/j.1536-4801.1985.tb08887.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 1985-06, Vol.4 (3), p.502-506 |
| issn | 0277-2116 1536-4801 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76230106 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adrenal Cortex Hormones - adverse effects Adrenal Cortex Hormones - therapeutic use Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Crohn Disease - blood Crohn Disease - therapy Emergency and intensive care: digestive diseases. Bioartificial liver Fat Emulsions, Intravenous - adverse effects Fat Emulsions, Intravenous - therapeutic use Female Humans Intensive care medicine Lipids - blood Male Medical sciences Osteonecrosis - etiology |
| title | Multifocal Osteonecrosis in Adolescents with CrohnʼS Disease: A Complication of Therapy? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T10%3A58%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multifocal%20Osteonecrosis%20in%20Adolescents%20with%20Crohn%CA%BCS%20Disease:%20A%20Complication%20of%20Therapy?&rft.jtitle=Journal%20of%20pediatric%20gastroenterology%20and%20nutrition&rft.au=Shapiro,%20Steven%20C&rft.date=1985-06&rft.volume=4&rft.issue=3&rft.spage=502&rft.epage=506&rft.pages=502-506&rft.issn=0277-2116&rft.eissn=1536-4801&rft.coden=JPGND6&rft_id=info:doi/10.1002/j.1536-4801.1985.tb08887.x&rft_dat=%3Cproquest_cross%3E76230106%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76230106&rft_id=info:pmid/4020583&rfr_iscdi=true |