First-Degree Relatives of Patients with Type I Diabetes Mellitus: Islet-Cell Antibodies and Abnormal Insulin Secretion

In a prospective study to evaluate the prevalence and predictive potential of circulating islet-cell antibodies, we have screened 1723 "normal" first-degree relatives (parents, siblings, and offspring) of patients with insulin-dependent diabetes mellitus. The prevalence of islet-cell antib...

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