Docking proteins

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated bin...

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Veröffentlicht in:The FEBS journal 2010-11, Vol.277 (21), p.4356-4369
Hauptverfasser: Brummer, Tilman, Schmitz-Peiffer, Carsten, Daly, Roger J
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container_title The FEBS journal
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creator Brummer, Tilman
Schmitz-Peiffer, Carsten
Daly, Roger J
description Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.
doi_str_mv 10.1111/j.1742-4658.2010.07865.x
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subjects Animals
Biochemistry
Cell Membrane - metabolism
Dok
DOS
FRS2
Gab
GRB2 Adaptor Protein - metabolism
Humans
Insulin Receptor Substrate Proteins - metabolism
Intracellular Signaling Peptides and Proteins - classification
Intracellular Signaling Peptides and Proteins - metabolism
IRS
Models, Biological
Molecular structure
Protein Binding
protein modules
protein phosphorylation
Protein-Tyrosine Kinases - metabolism
Proteins
SH2
Signal Transduction
Substrates
tyrosine kinase
title Docking proteins
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