Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study
Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies. Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age a...
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| Veröffentlicht in: | European journal of neurology 2010-11, Vol.17 (11), p.1346-1351 |
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| container_title | European journal of neurology |
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| creator | Pfleger, C. C. H. Flachs, E. M. Koch-Henriksen, N. |
| description | Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies.
Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age and symptom at onset.
Method: A total of 2240 Danes with onset of definite/probable MS 1980–1989, identified from the Danish MS‐Registry, were included. Information on social endpoints was retrieved from Statistics Denmark. Cox regression analyses were used with onset as starting point.
Results: Afferent onset symptoms [hazard ratio (HR 0.57)] and non‐physical type of work (HR 0.70) were favourable prognostic factors compared with high age at onset, physical work and efferent symptoms at onset. The mean time to disability pension was 13 years for patients with afferent/brainstem onset symptom but 8.7 years for those with efferent onset symptoms (P |
| doi_str_mv | 10.1111/j.1468-1331.2010.03020.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_762283884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4107861751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4340-75729c17291d8aaeafb7701e0ae73b4f99faa5a7f5fea8349ded63eaada00b243</originalsourceid><addsrcrecordid>eNqNkctu1DAUhiNERW-8ArLEglWGYzuJEyQWqDMdKpUBqSCW1hnnhPGQW-2knXl7nE6ZBSu8sI_s7z8X_1HEOMx4WO-3M55kecyl5DMB4RYkCJjtXkRnx4eXIZYpj1MO_DQ6934LAEIJeBWdCkhCmBZn0cNdZyzWzHStp_uRWkOedRVrxnqwfU3Mm5pc563_wExtW2sCjG3JSmq6Xw77jTWsd1RaM3TOs5gh21gf4ieyD9KezGAfKJTYdG5gfhjL_WV0UmHt6fXzeRH9uF58v_oc335d3lx9uo1NIhOIVapEYXjYeJkjElZrpYATICm5TqqiqBBTVFVaEeYyKUoqM0mIJQKsRSIvoneHvKGRMJ0fdGO9obrGlrrRa5UJkcs8n8i3_5DbbnRtaE7zHHgGqcjTQOUHyoTBvKNK98426Paag56s0Vs9OaAnB_RkjX6yRu-C9M1zgXHdUHkU_vUiAB8PwKOtaf_fifVitZiioI8P-vD9tDvq0f3WmZIq1T9XSy2_zJfz6_lKf5N_AJvTre4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1801605285</pqid></control><display><type>article</type><title>Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Pfleger, C. C. H. ; Flachs, E. M. ; Koch-Henriksen, N.</creator><creatorcontrib>Pfleger, C. C. H. ; Flachs, E. M. ; Koch-Henriksen, N.</creatorcontrib><description>Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies.
Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age and symptom at onset.
Method: A total of 2240 Danes with onset of definite/probable MS 1980–1989, identified from the Danish MS‐Registry, were included. Information on social endpoints was retrieved from Statistics Denmark. Cox regression analyses were used with onset as starting point.
Results: Afferent onset symptoms [hazard ratio (HR 0.57)] and non‐physical type of work (HR 0.70) were favourable prognostic factors compared with high age at onset, physical work and efferent symptoms at onset. The mean time to disability pension was 13 years for patients with afferent/brainstem onset symptom but 8.7 years for those with efferent onset symptoms (P < 0.0001). The effect of onset symptom was reduced and the effect of sex became significant when all covariates and age at onset were included in multivariate Cox regression.
Conclusions: Onset age, type of onset symptom and work are robust predictors of disability pension in MS. Disability pension proves to be a reliable milestone in estimation of the prognosis of MS.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/j.1468-1331.2010.03020.x</identifier><identifier>PMID: 20402759</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age ; Age of Onset ; Cohort Studies ; cohort study ; demographic predictors ; Demography ; Denmark ; Disability Evaluation ; disability pension ; Disability pensions ; Disabled Persons - statistics & numerical data ; Disease Progression ; early retirement ; Female ; Humans ; Male ; Medical prognosis ; Multiple sclerosis ; Multiple Sclerosis - economics ; Multiple Sclerosis - epidemiology ; occupational status ; Pensions - statistics & numerical data ; Predictive Value of Tests ; Probability ; Prognosis ; Proportional Hazards Models ; Retirement - statistics & numerical data</subject><ispartof>European journal of neurology, 2010-11, Vol.17 (11), p.1346-1351</ispartof><rights>2010 The Author(s). Journal compilation © 2010 EFNS</rights><rights>2010 The Author(s). Journal compilation © 2010 EFNS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4340-75729c17291d8aaeafb7701e0ae73b4f99faa5a7f5fea8349ded63eaada00b243</citedby><cites>FETCH-LOGICAL-c4340-75729c17291d8aaeafb7701e0ae73b4f99faa5a7f5fea8349ded63eaada00b243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1331.2010.03020.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1331.2010.03020.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20402759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfleger, C. C. H.</creatorcontrib><creatorcontrib>Flachs, E. M.</creatorcontrib><creatorcontrib>Koch-Henriksen, N.</creatorcontrib><title>Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies.
Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age and symptom at onset.
Method: A total of 2240 Danes with onset of definite/probable MS 1980–1989, identified from the Danish MS‐Registry, were included. Information on social endpoints was retrieved from Statistics Denmark. Cox regression analyses were used with onset as starting point.
Results: Afferent onset symptoms [hazard ratio (HR 0.57)] and non‐physical type of work (HR 0.70) were favourable prognostic factors compared with high age at onset, physical work and efferent symptoms at onset. The mean time to disability pension was 13 years for patients with afferent/brainstem onset symptom but 8.7 years for those with efferent onset symptoms (P < 0.0001). The effect of onset symptom was reduced and the effect of sex became significant when all covariates and age at onset were included in multivariate Cox regression.
Conclusions: Onset age, type of onset symptom and work are robust predictors of disability pension in MS. Disability pension proves to be a reliable milestone in estimation of the prognosis of MS.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Cohort Studies</subject><subject>cohort study</subject><subject>demographic predictors</subject><subject>Demography</subject><subject>Denmark</subject><subject>Disability Evaluation</subject><subject>disability pension</subject><subject>Disability pensions</subject><subject>Disabled Persons - statistics & numerical data</subject><subject>Disease Progression</subject><subject>early retirement</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - economics</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>occupational status</subject><subject>Pensions - statistics & numerical data</subject><subject>Predictive Value of Tests</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retirement - statistics & numerical data</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhiNERW-8ArLEglWGYzuJEyQWqDMdKpUBqSCW1hnnhPGQW-2knXl7nE6ZBSu8sI_s7z8X_1HEOMx4WO-3M55kecyl5DMB4RYkCJjtXkRnx4eXIZYpj1MO_DQ6934LAEIJeBWdCkhCmBZn0cNdZyzWzHStp_uRWkOedRVrxnqwfU3Mm5pc563_wExtW2sCjG3JSmq6Xw77jTWsd1RaM3TOs5gh21gf4ieyD9KezGAfKJTYdG5gfhjL_WV0UmHt6fXzeRH9uF58v_oc335d3lx9uo1NIhOIVapEYXjYeJkjElZrpYATICm5TqqiqBBTVFVaEeYyKUoqM0mIJQKsRSIvoneHvKGRMJ0fdGO9obrGlrrRa5UJkcs8n8i3_5DbbnRtaE7zHHgGqcjTQOUHyoTBvKNK98426Paag56s0Vs9OaAnB_RkjX6yRu-C9M1zgXHdUHkU_vUiAB8PwKOtaf_fifVitZiioI8P-vD9tDvq0f3WmZIq1T9XSy2_zJfz6_lKf5N_AJvTre4</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Pfleger, C. C. H.</creator><creator>Flachs, E. M.</creator><creator>Koch-Henriksen, N.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201011</creationdate><title>Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study</title><author>Pfleger, C. C. H. ; Flachs, E. M. ; Koch-Henriksen, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4340-75729c17291d8aaeafb7701e0ae73b4f99faa5a7f5fea8349ded63eaada00b243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age</topic><topic>Age of Onset</topic><topic>Cohort Studies</topic><topic>cohort study</topic><topic>demographic predictors</topic><topic>Demography</topic><topic>Denmark</topic><topic>Disability Evaluation</topic><topic>disability pension</topic><topic>Disability pensions</topic><topic>Disabled Persons - statistics & numerical data</topic><topic>Disease Progression</topic><topic>early retirement</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - economics</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>occupational status</topic><topic>Pensions - statistics & numerical data</topic><topic>Predictive Value of Tests</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retirement - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfleger, C. C. H.</creatorcontrib><creatorcontrib>Flachs, E. M.</creatorcontrib><creatorcontrib>Koch-Henriksen, N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfleger, C. C. H.</au><au>Flachs, E. M.</au><au>Koch-Henriksen, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2010-11</date><risdate>2010</risdate><volume>17</volume><issue>11</issue><spage>1346</spage><epage>1351</epage><pages>1346-1351</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background: Time to disability pension is one of the endpoints to be used to determine the prognosis of multiple sclerosis (MS) in prospective studies.
Objective: To assess the time to cessation of work and receiving disability pension in MS, and how it may depend on gender, type of work and age and symptom at onset.
Method: A total of 2240 Danes with onset of definite/probable MS 1980–1989, identified from the Danish MS‐Registry, were included. Information on social endpoints was retrieved from Statistics Denmark. Cox regression analyses were used with onset as starting point.
Results: Afferent onset symptoms [hazard ratio (HR 0.57)] and non‐physical type of work (HR 0.70) were favourable prognostic factors compared with high age at onset, physical work and efferent symptoms at onset. The mean time to disability pension was 13 years for patients with afferent/brainstem onset symptom but 8.7 years for those with efferent onset symptoms (P < 0.0001). The effect of onset symptom was reduced and the effect of sex became significant when all covariates and age at onset were included in multivariate Cox regression.
Conclusions: Onset age, type of onset symptom and work are robust predictors of disability pension in MS. Disability pension proves to be a reliable milestone in estimation of the prognosis of MS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20402759</pmid><doi>10.1111/j.1468-1331.2010.03020.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Age of Onset Cohort Studies cohort study demographic predictors Demography Denmark Disability Evaluation disability pension Disability pensions Disabled Persons - statistics & numerical data Disease Progression early retirement Female Humans Male Medical prognosis Multiple sclerosis Multiple Sclerosis - economics Multiple Sclerosis - epidemiology occupational status Pensions - statistics & numerical data Predictive Value of Tests Probability Prognosis Proportional Hazards Models Retirement - statistics & numerical data |
| title | Social consequences of multiple sclerosis: clinical and demographic predictors - a historical prospective cohort study |
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