Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa

Inula racemosa Hook.f. commonly known as Pushkarmula ( Compositae) has been used as a traditional drug in India, China and Europe. In the present study, 95% ethanolic extract of roots and its fractions ( n-hexane, chloroform, n-butanol and aqueous) were evaluated for in vitro cytotoxicity against ca...

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Veröffentlicht in:	Toxicology in vitro 2010-09, Vol.24 (6), p.1599-1609
Hauptverfasser:	Pal, Harish Chandra, Sehar, Irum, Bhushan, Shashi, Gupta, Bishan Dutt, Saxena, Ajit Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Caspases - biosynthesis Cell Survival - drug effects Chromatography, High Pressure Liquid Compositae Cytotoxicity DNA, Neoplasm - analysis Enzyme Activation - drug effects HL-60 Cells Humans Inhibitory Concentration 50 Inula Inula - chemistry Inula racemosa Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Poly(ADP-ribose) Polymerases - metabolism Reactive Oxygen Species - metabolism Tumor growth inhibition Tumor Stem Cell Assay
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