Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury

Objective and design Toll-like receptor 4 (TLR4) plays important roles in the recognition of lipopolysaccharide (LPS) and the activation of inflammatory cascade. In this study, we evaluated the effect of TAK-242, a selective TLR4 signal transduction inhibitor, on acute lung injury (ALI). Materials a...

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Veröffentlicht in:	Inflammation research 2010-10, Vol.59 (10), p.837-845
Hauptverfasser:	Seki, Hiroyuki, Tasaka, Sadatomo, Fukunaga, Koichi, Shiraishi, Yoshiki, Moriyama, Kiyoshi, Miyamoto, Keisuke, Nakano, Yasushi, Matsunaga, Naoko, Takashima, Katsunori, Matsumoto, Tatsumi, Ii, Masayuki, Ishizaka, Akitoshi, Takeda, Junzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - immunology Allergology Animals Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Chemokines - immunology Cytokines - immunology Dermatology Endotoxin Humans Immunology Inflammation Mediators - immunology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Male Mice Mice, Inbred C57BL Neurology NF-kappa B - immunology NF-κB Original Research Paper Pharmacology/Toxicology Rheumatology rodents Signal Transduction - drug effects Signal Transduction - immunology Sulfonamides - metabolism Sulfonamides - pharmacology Sulfonamides - therapeutic use Toll-like receptor 4 Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - immunology
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