Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity

Duchenne muscular dystrophy is a fatal, genetic disorder in which dystrophin-deficient muscle progressively degenerates, for which dystrophin gene transfer could provide effective treatment. The host immune response to dystrophin, however, is an obstacle to therapeutic gene expression. Understanding...

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Veröffentlicht in:	Gene therapy 2010-09, Vol.17 (9), p.1181-1190
Hauptverfasser:	Eghtesad, S, Zheng, H, Nakai, H, Epperly, M W, Clemens, P R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2300 631/208/2489/144 631/250/2152/2153 692/698/1671/1668 Adoptive transfer Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antisense DNA Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Bone marrow Bone marrow transplantation Cell Biology Cell-mediated immunity DNA, Complementary - administration & dosage Duchenne muscular dystrophy Duchenne's muscular dystrophy Dystrophin Dystrophin - genetics Dystrophin - immunology Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic aspects Genetic disorders Genetic Vectors Health aspects Health. Pharmaceutical industry Human Genetics Humoral immunity Immune response (humoral) Immunity, Humoral - radiation effects Immunoregulation Industrial applications and implications. Economical aspects Irradiation Lymphocytes T Medical sciences Mice Mice, Inbred mdx Muscular dystrophy Muscular Dystrophy, Duchenne - immunology Nanotechnology original-article Physiological aspects Radiation Radiation therapy Risk factors Rodents T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects Transfusions. Complications. Transfusion reactions. Cell and gene therapy Whole-Body Irradiation
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