Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia

Purpose Type 2 diabetes is associated with an increased risk of acquiring infectious diseases and developing sepsis. This may partly be due to immune dysfunction. We investigated the in vivo innate immune response of type 2 diabetic persons to an intravenous injection of E. coli lipopolysaccharide (...

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Veröffentlicht in:	Intensive care medicine 2010-09, Vol.36 (9), p.1548-1555
Hauptverfasser:	Andreasen, Anne Sofie, Pedersen-Skovsgaard, Theis, Berg, Ronan M. G., Svendsen, Kira Dynnes, Feldt-Rasmussen, Bo, Pedersen, Bente K., Møller, Kirsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Associated diseases and complications Biological and medical sciences Biomarkers - blood Blood cell count Cell Adhesion Molecules - metabolism Communicable diseases Critical Care Medicine Cytokines - blood Development and progression Diabetes Mellitus, Type 2 - immunology Diabetes. Impaired glucose tolerance Diabetics Emergency Medicine Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endotoxemia - metabolism Endotoxins - pharmacology Escherichia coli Ethical aspects Ethylenediaminetetraacetic acid Heart beat Humans Immune response Infection Intensive Intensive care medicine Interleukin-1 - blood Interleukins Lipopolysaccharides - pharmacology Male Medical sciences Medicine Medicine & Public Health Middle Aged Original Pain Medicine Pediatrics Physiological aspects Pneumology/Respiratory System Tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Type 2 diabetes Vascular Cell Adhesion Molecule-1 - blood
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