The effect of epigenetic sperm abnormalities on early embryogenesis
Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to the oocyte. The epigenetic, or gene regulatory, properties and mechanisms of the sperm assist in preparation of the paternal genome to contribute to embryogenesis and the genome of the zygote. Many recent stud...
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| Veröffentlicht in: | Asian journal of andrology 2006-03, Vol.8 (2), p.131-142 |
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| container_title | Asian journal of andrology |
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| creator | Emery, Benjamin R Carrell, Douglas T |
| description | Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to the oocyte. The epigenetic, or gene regulatory, properties and mechanisms of the sperm assist in preparation of the paternal genome to contribute to embryogenesis and the genome of the zygote. Many recent studies have addressed the issue of altered epigenetic processes in the sperm. This review evaluates the current understanding of DNA damage, chromosome aneuploidy, reduced telomere length, malformations of the centrosome, genomic imprinting errors, altered mRNA profiles, and abnormal nuclear packaging in the sperm prior to fertilization and the observed effects on embryogenesis. Attention has also been given to understanding the underlying etiology of sperm with altered epigenetic mechanisms in humans. （Asian J Androl 2006 Mar; 8： 131-142） |
| doi_str_mv | 10.1111/j.1745-7262.2006.00127.x |
| format | Article |
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| identifier | ISSN: 1008-682X |
| ispartof | Asian journal of andrology, 2006-03, Vol.8 (2), p.131-142 |
| issn | 1008-682X 1745-7262 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aneuploidy Animals Cell Nucleus - physiology Centrosome - pathology DNA Damage - physiology Embryonic Development - physiology Epigenesis, Genetic Genomic Imprinting - physiology Humans Infertility, Male - genetics Male RNA, Messenger - physiology Spermatozoa - abnormalities Spermatozoa - physiology Telomere - genetics 中心体 精子质量 胚胎形成 |
| title | The effect of epigenetic sperm abnormalities on early embryogenesis |
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